Structure-based virtual screening for PDL1 dimerizers: Evaluating generic scoring functions [0.03%]
基于结构的虚拟筛选PDL1二聚体化分子：评估通用打分函数
Viet-Khoa Tran-Nguyen,Saw Simeon,Muhammad Junaid et al.
Viet-Khoa Tran-Nguyen et al.
The interaction between PD1 and its ligand PDL1 has been shown to render tumor cells resistant to apoptosis and promote tumor progression. An innovative mechanism to inhibit the PD1/PDL1 interaction is PDL1 dimerization induced by small-mol...
Integrative structural studies of the SARS-CoV-2 spike protein during the fusion process (2022) [0.03%]
SARS-CoV-2刺突蛋白融合过程中的集成结构研究（2022）
Jacob C Miner,Paul W Fenimore,William M Fischer et al.
Jacob C Miner et al.
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic and catastrophic, worldwide health and economic impacts. The spike protein on the viral surface is responsible for viral entry into the host cell. The binding of spike protein to...
Structural and functional insights into the DNA damage-inducible protein 1 (Ddi1) from protozoa [0.03%]
来自原生动物的DNA损伤诱导蛋白1(Ddi1)的结构和功能见解
Killivalavan Asaithambi,Iman Biswas,Kaza Suguna
Killivalavan Asaithambi
Ddi1 is a multidomain protein that belongs to the ubiquitin receptor family of proteins. The Ddi1 proteins contain a highly conserved retroviral protease (RVP)-like domain along with other domains. The severity of opportunistic infections, ...
Zhixiang Wu,Zhongjie Han,Wenxue Zhou et al.
Zhixiang Wu et al.
The human equilibrative nucleoside transporter 1 (hENT1) is an effective controller of adenosine signaling by regulating its extracellular and intracellular concentration, and has become a solid drug target of clinical used adenosine reupta...
HPMPdb: A machine learning-ready database of protein molecular phenotypes associated to human missense variants [0.03%]
HPMPdb：与人类错义突变相关的蛋白质分子表型的机器学习就绪数据库
Daniele Raimondi,Francesco Codicè,Gabriele Orlando et al.
Daniele Raimondi et al.
Current human Single Amino acid Variants (SAVs) databases provide a link between a SAVs and their effect on the carrier individual phenotype, often dividing them into Deleterious/Neutral variants. This is a very coarse-grained description o...
A cryptic phosphate-binding pocket on the SPFH domain of human stomatin that regulates a novel fibril-like self-assembly [0.03%]
人源stomatin(SPFH)结构域上的一个隐秘的磷酸盐结合区可调节一种新颖的纤维样自我组装体
Koki Kataoka,Shota Suzuki,Takeshi Tenno et al.
Koki Kataoka et al.
Human stomatin (hSTOM) is a component of the membrane skeleton of erythrocytes that maintains the membrane's shape and stiffness through interconnecting spectrin and actin. hSTOM is a member of the protein family that possesses a single sto...
Multifaceted membrane binding head of the SARS-CoV-2 spike protein [0.03%]
SARS-CoV-2刺突蛋白多面体的膜结合头部结构
Anh Tran,Troy A Kervin,Michael Overduin
Anh Tran
The SARS-CoV-2 spike protein presents a surface with enormous membrane binding potential to host tissues and organelles of infected cells. Its exposed trimeric head binds not only the angiotensin-converting enzyme 2 (ACE2), but also host ph...
Understanding structural variability in proteins using protein structural networks [0.03%]
利用蛋白质结构网络理解蛋白质的结构变异性
Vasam Manjveekar Prabantu,Vasundhara Gadiyaram,Saraswathi Vishveshwara et al.
Vasam Manjveekar Prabantu et al.
Proteins perform their function by accessing a suitable conformer from the ensemble of available conformations. The conformational diversity of a chosen protein structure can be obtained by experimental methods under different conditions. A...
FOXO transcription factors differ in their dynamics and intra/intermolecular interactions [0.03%]
FOXO转录因子在动态性和分子/跨分子相互作用上有所不同
Emil Spreitzer,T Reid Alderson,Benjamin Bourgeois et al.
Emil Spreitzer et al.
Transcription factors play key roles in orchestrating a plethora of cellular mechanisms and controlling cellular homeostasis. Transcription factors share distinct DNA binding domains, which allows to group them into protein families. Among ...
Nonexponential kinetics captured in sequential unfolding of polyproteins over a range of loads [0.03%]
多项链蛋白在不同负荷下的逐级解折叠非指数动力学现象
Einat Chetrit,Sabita Sharma,Uri Maayan et al.
Einat Chetrit et al.
While performing under mechanical loads in vivo, polyproteins are vitally involved in cellular mechanisms such as regulation of tissue elasticity and mechano-transduction by unfolding their comprising domains and extending them. It is widel...