Acute arsenic trioxide inhibits the cardiac transient outward K+ current (Ito) and human Kv4.3/KChIP2c channels [0.03%]
三氧化二砷急性抑制心脏瞬时外向钾电流(Ito)和人Kv4.3/KChIP2c通道
Claudia Mancilla Simbro,Ángel A Islas,Fritzy D Herrera Salcedo et al.
Claudia Mancilla Simbro et al.
Arsenic trioxide (As2O3) has been useful to treat acute promyelocytic leukaemia, as it inhibits the growth of various tumour cell lines and promotes apoptosis. However, its employment has been hindered by its cardiotoxic potential, since it...
Screening for novel chemical scaffolds targeting PCNA identifies the Hsp90alpha inhibitor SNX-2112 [0.03%]
针对PCNA的新化学骨架筛选鉴定出Hsp90α抑制剂SNX-2112
Jennifer Jossart,Ning Ma,Pouya Haratipour et al.
Jennifer Jossart et al.
Proliferating cell nuclear antigen (PCNA) protein is an emerging therapeutic target for several diseases including cancers, and certain viral infections. It was previously regarded as being undruggable, due to its functions as a molecular h...
Deciphering hydration patterns across RNA conformations: Insights into water-mediated RNA recognition [0.03%]
破解RNA构象中的水和RNA识别机制的关系
Arghya P Ghosh,Julia N DuVal,Adrianna M Cavoto et al.
Arghya P Ghosh et al.
Water molecules play a vital role in stabilizing ribonucleic acid (RNA) structures, not only as a solvent but as active participants in molecular recognition. Yet how hydration patterns encode binding specificity across RNA conformations re...
Decoding the impact of nsSNP variants on BCL6 function through integrated computational analysis [0.03%]
通过集成计算分析解码nsSNP变异对BCL6功能的影响
Shaden M H Mubarak,Pardis Abdali Dehdezi,Amir Razavinia et al.
Shaden M H Mubarak et al.
BCL6 plays significant roles in various cellular processes and malignancies such as diffuse large B-cell lymphoma. BCL6 performs its functions through binding of its BTB domain to different corepressors. Thus, analyzing the possible structu...
Induced-proximity therapeutics for targeted protein and RNA degradation: An organic chemistry Perspective-A review [0.03%]
诱导接近的治疗学：用于靶向蛋白质和RNA降解的有机化学视角-综述
Mohammad Rizehbandi,Ehsan Dadfar,Mahyar Rezaei Nami et al.
Mohammad Rizehbandi et al.
Induced-proximity therapeutics have emerged as a transformative paradigm in chemical biology and drug discovery, enabling selective control of cellular processes beyond conventional inhibitors. Between 2020 and 2025, major progress has been...
Molecular determinants of TNFR1:TNFα binding and dynamics in a physiological membrane environment [0.03%]
生理膜环境下的TNFR1:TNFα结合及动力学的分子决定因素
Elena Álvarez Sánchez,Simon Huet,Stéphane Téletchéa
Elena Álvarez Sánchez
Tumor Necrosis Factor alpha (TNFα) is a pro-inflammatory cytokine critical for regulating cell survival and death. Under pathological conditions, excessive TNFα activity can lead to chronic inflammation, contributing to diseases such as i...
Structural and mechanistic divergence in LL-37, HNP-1, and Magainin-2: An integrated computational and biophysical analysis [0.03%]
LL-37、HNP-1和Magainin-2的结构与机理分化：整合计算与生物物理分析
Sinethemba H Yakobi,Uchechukwu U Nwodo
Sinethemba H Yakobi
Escalating antimicrobial resistance necessitates the development of alternative therapeutics that circumvent conventional enzymatic and efflux-based defence systems. Antimicrobial peptides (AMPs) represent a compelling class of innate immun...
Looking at bacterial cell poles from a liquid-liquid phase separation of intrinsically disordered proteins perspective [0.03%]
从固有无序蛋白液-液相分离的角度审视细菌细胞极体内含物
Raneem Aldadah,Delila Lekic,Kanita Sabanovic et al.
Raneem Aldadah et al.
Bacterial cell poles play a fundamental role in several cellular processes, such as cell cycle, chemotaxis, cell differentiation, development, growth, and structure of the bacterial cell, as well as protein localization. Using a set of bioi...
ADMET, QSAR and Docking studies to predict the activity of tyrosinase-derived medications inhibitors based on computational techniques [0.03%]
基于计算技术的酪氨酸酶衍生药物抑制剂活性预测的ADMET、QSAR和对接研究
Adele Sadat Haghighat Hoseini,Abed Mohebshahedin,Shamim Ghiabi et al.
Adele Sadat Haghighat Hoseini et al.
The tyrosinase enzyme plays a pivotal role in melanin pigment production; however, heightened tyrosinase activity can lead to undesired pigmentation. Consequently, inhibiting this enzyme's function stands as a critical research avenue for d...
Functional (re)annotation of Mycobacteroides abscessus proteome using integrative sequence and AI-based structural approaches [0.03%]
利用集成序列和基于AI的结构方法对胞饮分支菌脓肿亚种蛋白质组进行功能(重新)注释
Pranavathiyani Gnanasekar,Simran Gambhir,Priyadarshan Kinatukara et al.
Pranavathiyani Gnanasekar et al.
Functional annotation of proteins is crucial in understanding the basic biology of organisms. In the context of pathogens, it can provide valuable insights towards its functional landscape contributing to understanding the molecular mechani...