Structural rationale to understand the effect of disease-associated mutations on Myotubularin [0.03%]
肌 tubularin 疾病相关突变作用的结构原理分析
Teerna Bhattacharyya,Avishek Ghosh,Shailya Verma et al.
Teerna Bhattacharyya et al.
Myotubularin or MTM1 is a lipid phosphatase that regulates vesicular trafficking in the cell. The MTM1 gene is mutated in a severe form of muscular disease, X-linked myotubular myopathy or XLMTM, affecting 1 in 50,000 newborn males worldwid...
A cytosine-patch sequence motif identified in the conserved region of lincRNA-p21 interacts with the KH3 domain of hnRNPK [0.03%]
在lincRNA-p21保守区域中鉴定到的胞嘧啶富集序列基序与hnRNPK蛋白KH3结构域相互作用
Aditi Maulik,Devleena Bandopadhyay,Mahavir Singh
Aditi Maulik
Long Intergenic Non-coding RNAs (lincRNAs) are the largest class of long non-coding RNAs in eukaryotes, originating from the genome's intergenic regions. A ∼4 kb long lincRNA-p21 is derived from a transcription unit next to the p21/Cdkn1...
Structural modelling and dynamics of full-length of TLR10 sheds light on possible modes of dimerization, ligand binding and mechanism of action [0.03%]
全长TLR10结构模型及其动力学研究揭示了其二聚化、配体结合及作用机制的可能模式
Vikas Tiwari,R Sowdhamini
Vikas Tiwari
Toll like receptors (TLRs) play a pivotal role in innate and adaptive immunity. There are 10 TLRs in the human genome, of which TLR10 is the least characterized. Genetic polymorphism of TLR10 has been shown to be associated with multiple di...
Identification and prioritization of potential therapeutic molecules against LpxA from Acinetobacter baumannii - A computational study [0.03%]
计算研究识别和优先确定对阿波普菌LpxA的潜在治疗分子
Rameez Jabeer Khan,Ekampreet Singh,Rajat Kumar Jha et al.
Rameez Jabeer Khan et al.
A. baumannii is a ubiquitously found gram-negative, multi-drug resistant bacterial species from the ESKAPE family of pathogens known to be the causative agent for hospital-acquired infections such as pneumonia, meningitis, endocarditis, sep...
Structure of the Saccharolobus solfataricus type III-D CRISPR effector [0.03%]
硫化磺细菌III-D型CRISPR效应物的结构
Giuseppe Cannone,Dmytro Kompaniiets,Shirley Graham et al.
Giuseppe Cannone et al.
CRISPR-Cas is a prokaryotic adaptive immune system, classified into six different types, each characterised by a signature protein. Type III systems, classified based on the presence of a Cas10 subunit, are rather diverse multi-subunit asse...
Structure of Helicobacter pylori dihydroneopterin aldolase suggests a fragment-based strategy for isozyme-specific inhibitor design [0.03%]
Helicobacter pylori 二氢蝶啶合成酶的结构为其异构酶特异性片段抑制剂的设计提供了依据
Gary X Shaw,Lixin Fan,Scott Cherry et al.
Gary X Shaw et al.
Dihydroneopterin aldolase (DHNA) is essential for folate biosynthesis in microorganisms. Without a counterpart in mammals, DHNA is an attractive target for antimicrobial agents. Helicobacter pylori infection occurs in human stomach of over ...
Structural biology - Painting the mechanistic landscape of biomolecules [0.03%]
结构生物学 - 绘制生物分子的作用机制景观
Tom L Blundell,Peter E Wright
Tom L Blundell
Amyloid management by chaperones: The mystery underlying protein oligomers' dual functions [0.03%]
分子伴娘通过处理淀粉样蛋白来管理蛋白质寡聚物的双重功能之谜
Payam Arghavani,Mitra Pirhaghi,Faezeh Moosavi-Movahedi et al.
Payam Arghavani et al.
Protein oligomerization has two notable aspects: it is crucial for the performing cellular and molecular processes accurately, and it produces amyloid fibril precursors. Although a clear explanation for amyloidosis as a whole is lacking, mo...
Ibrahim Yagiz Akbayrak,Sule Irem Caglayan,Lukasz Kurgan et al.
Ibrahim Yagiz Akbayrak et al.
SARS-CoV-2 is the infectious agent responsible for the coronavirus disease since 2019, which is the viral pneumonia pandemic worldwide. The structural knowledge on SARS-CoV-2 is rather limited. These limitations are also applicable to one o...
Stability and conformational memory of electrosprayed and rehydrated bacteriophage MS2 virus coat proteins [0.03%]
电喷雾和重新水化的噬菌体MS2病毒衣壳蛋白的稳定性及构象记忆
Maxim N Brodmerkel,Emiliano De Santis,Charlotte Uetrecht et al.
Maxim N Brodmerkel et al.
Proteins are innately dynamic, which is important for their functions, but which also poses significant challenges when studying their structures. Gas-phase techniques can utilise separation and a range of sample manipulations to transcend ...