Cholesterol modulates the structural dynamics of the paddle motif loop of KvAP voltage sensor [0.03%]
胆固醇调节KvAP电压感受器桨模结构动态性
Anindita Das,Arpan Bysack,H Raghuraman
Anindita Das
KvAP is a prokaryotic Kv channel, which has been widely used as a model system to understand voltage- and lipid-dependent gating mechanisms. In phospholipid membranes, the KvAP-VSD adopts the activated/'Up' conformation, whereas the presenc...
Structure-function analyses reveal Arabidopsis thaliana HDA7 to be an inactive histone deacetylase [0.03%]
结构功能分析揭示了拟南芥HDA7是一种失活的组蛋白去乙酰化酶
Ketul Saharan,Somanath Baral,Nausad Hossain Shaikh et al.
Ketul Saharan et al.
Histone deacetylases (HDACs), responsible for the removal of acetyl groups from histone tails, are important epigenetic factors. They play a critical role in the regulation of gene expression and are significant in the context of plant grow...
Mechanism of drug resistance in HIV-1 protease subtype C in the presence of Atazanavir [0.03%]
在Atazanavir存在的情况下HIV-1 C型蛋白酶的抗药性机制
S V Sankaran,Sowmya R Krishnan,Yasien Sayed et al.
S V Sankaran et al.
AIDS is one of the deadliest diseases in the history of humankind caused by HIV. Despite the technological development, curtailing the viral infection inside human host still remains a challenge. Therapies such as HAART uses a combination o...
Ankush Garg,Gaurav Kumar,Varinder Singh et al.
Ankush Garg et al.
Liquid-liquid phase separation plays a crucial role in cellular physiology, as it leads to the formation of membrane-less organelles in response to various internal stimuli, contributing to various cellular functions. However, the influence...
Assessment of Kaistella jeonii esterase conformational dynamics in response to poly(ethylene terephthalate) binding [0.03%]
Kaistella jeonii酯酶构象动力学对聚乙烯对苯二甲酸盐结合的反应评估
Ederson Sales Moreira Pinto,Arthur Tonietto Mangini,Lorenzo Chaves Costa Novo et al.
Ederson Sales Moreira Pinto et al.
The pervasive presence of plastic in the environment has reached a concerning scale, being identified in many ecosystems. Bioremediation is the cheapest and most eco-friendly alternative to remove this polymer from affected areas. Recent wo...
Ki Hyun Nam
Ki Hyun Nam
Serial crystallography (SX) is an emerging technique that can be used to determine the noncryogenic crystal structure of macromolecules while minimizing radiation damage. Applying SX using pump-probe or mix-and-inject techniques enables the...
Living in trinity of extremes: Genomic and proteomic signatures of halophilic, thermophilic, and pH adaptation [0.03%]
生活在三重极端环境中：嗜盐，嗜热和pH适应的基因组和蛋白质组特征
Aidana Amangeldina,Zhen Wah Tan,Igor N Berezovsky
Aidana Amangeldina
Since nucleic acids and proteins of unicellular prokaryotes are directly exposed to extreme environmental conditions, it is possible to explore the genomic-proteomic compositional determinants of molecular mechanisms of adaptation developed...
Computational identification of candidate inhibitors for Dihydrofolate reductase in Acinetobacter baumannii [0.03%]
计算识别鲍曼不动杆菌二氢叶酸还原酶的候选抑制剂
Saurabh Kumar Bhati,Monika Jain,Jayaraman Muthukumaran et al.
Saurabh Kumar Bhati et al.
Acinetobacter baumannii is one of the emerging causes of hospital acquired infections and this bacterium, due to multi-drug resistant and Extensive Drug resistant has been able to develop resistance against the antimicrobial agents that are...
Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery [0.03%]
靶向HIV-1蛋白酶的药物对恶性疟原虫血蒙肽酶的抑制作用：抗疟药物研发的新途径
Vandana Mishra,Anuradha Deshmukh,Ishan Rathore et al.
Vandana Mishra et al.
Plasmodium species are causative agents of malaria, a disease that is a serious global health concern. FDA-approved HIV-1 protease inhibitors (HIV-1 PIs) have been reported to be effective in reducing the infection by Plasmodium parasites i...
Bioinformatic analysis of THAP9 transposase homolog: conserved regions, novel motifs [0.03%]
THAP9转座酶同源物的生物信息学分析：保守区和新的基序
Richa Rashmi,Chandan Nandi,Sharmistha Majumdar
Richa Rashmi
THAP9 is a transposable element-derived gene that encodes the THAP9 protein, which is homologous to the Drosophila P-element transposase (DmTNP) and can cut and paste DNA. However, the exact functional role of THAP9 is unknown. Here, we per...