Conformational analysis of the IQSEC2 protein by statistical thermodynamics [0.03%]
统计热力学在IQSEC2蛋白构象分析中的应用研究
Michael Shokhen,Amnon Albeck,Veronika Borisov et al.
Michael Shokhen et al.
Mutations in the IQSEC2 gene result in severe intellectual disability, epilepsy and autism. The primary function of IQSEC2 is to serve as a guanine exchange factor (GEF) controlling the activation of ARF6 which in turn mediates membrane tra...
Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases in Mycobacteria [0.03%]
结核分枝杆菌中Ib类核糖核苷酸还原酶自由基形成启动机制的结构洞察
Lumbini R Yadav,Vasudha Sharma,Maheswaran Shanmugam et al.
Lumbini R Yadav et al.
Class I ribonucleotide reductases consisting of α and β subunits convert ribonucleoside diphosphates to deoxyribonucleoside diphosphates involving an intricate free radical mechanism. The generation of free radicals in the Class Ib ribonu...
Structural insights into the disulfide isomerase and chaperone activity of TrbB of the F plasmid type IV secretion system [0.03%]
F质粒类型IV分泌系统的TrbB的二硫键异构酶和分子伴侣活性的结构见解
Arnold J Apostol,Nicholas J Bragagnolo,Christina S Rodriguez et al.
Arnold J Apostol et al.
Bacteria have evolved elaborate mechanisms to thrive in stressful environments. F-like plasmids in gram-negative bacteria encode for a multi-protein Type IV Secretion System (T4SSF) that is functional for bacterial proliferation and adaptat...
Structural and functional insights of sortases and their interactions with antivirulence compounds [0.03%]
关于分 SORTASES 结酶的结构和功能及其与抗毒力化合物相互作用的见解
Sowmiya Sri Sivaramalingam,Deepsikha Jothivel,Deenadayalan Karaiyagowder Govindarajan et al.
Sowmiya Sri Sivaramalingam et al.
Sortase proteins play a crucial role as integral membrane proteins in anchoring bacterial surface proteins by recognizing them through a Cell-Wall Sorting (CWS) motif and cleaving them at specific sites before initiating pilus assembly. Bot...
Evaluating therapeutic potential of AYUSH-64 constituents against omicron variant of SARS-CoV-2 using ensemble docking and simulations [0.03%]
采用集成对接和模拟评估AYUSH-64成分针对奥密克戎变异株的治疗潜力
Vinod Jani,Shruti Koulgi,Mallikarjunachari V N Uppuladinne et al.
Vinod Jani et al.
The COVID-19 pandemic in the later phase showed the presence of the B.1.1.529 variant of the SARS-CoV-2 designated as Omicron. AYUSH-64 a poly herbal drug developed by Central Council for Research in Ayurvedic Sciences (CCRAS) has been reco...
Aakanksha Singh,Bidisha Acharya,Beas Mukherjee et al.
Aakanksha Singh et al.
Extradenticle (EXD) is a partner protein of the HOX transcription factors and plays an important role in the development of Drosophila. It confers increased affinity and specificity of DNA-binding to the HOX proteins. However, the DNA-bindi...
GraSp-PSN: A web server for graph spectra based analysis of protein structure networks [0.03%]
基于蛋白质结构网络图形谱分析的网络服务器 GraSp-PSN
Vasundhara Gadiyaram,Vasam Manjveekar Prabantu,Arinnia Anto Manjaly et al.
Vasundhara Gadiyaram et al.
The function of a protein is most of the time achieved due to minute conformational changes in its structure due to ligand binding or environmental changes or other interactions. Hence the analysis of structure of proteins should go beyond ...
Membrane binding and lipid-protein interaction of the C2 domain from coagulation factor V [0.03%]
凝血因子V的C2结构域与膜的结合及其脂类-蛋白质相互作用
Y Zenmei Ohkubo,Peter W Radulovic,Albert N Kahira et al.
Y Zenmei Ohkubo et al.
Anchoring of coagulation factors to anionic regions of the membrane involves the C2 domain as a key player. The rate of enzymatic reactions of the coagulation factors is increased by several orders of magnitude upon membrane binding. Howeve...
The impact of SARS-CoV-2 spike mutation on peptide presentation is HLA allomorph-specific [0.03%]
SARS-CoV-2刺突蛋白突变体的肽抗原呈递效应具有HLA亚型特异性
You Min Ahn,Janesha C Maddumage,Emma J Grant et al.
You Min Ahn et al.
CD8+ T cells are crucial for viral elimination and recovery from viral infection. Nonetheless, the current understanding of the T cell response to SARS-CoV-2 at the antigen level remains limited. The Spike protein is an external structural ...
Structure and function of the light-protective orange carotenoid protein families [0.03%]
光保护橙色类胡萝卜素蛋白家族的结构和功能
Teresa M García-Oneto,Claudia Moyano-Bellido,M Agustina Domínguez-Martín
Teresa M García-Oneto
Orange carotenoid proteins (OCPs) are unique photoreceptors that are critical for cyanobacterial photoprotection. Upon exposure to blue-green light, OCPs are activated from a stable orange form, OCPO, to an active red form, OCPR, which bind...