Structure/Function Analysis of human ZnT8 (SLC30A8): A Diabetes Risk Factor and Zinc Transporter [0.03%]
人ZnT8(SLC30A8)的结构与功能研究：糖尿病风险因子及锌转运体
Mark J Daniels,Maciej Jagielnicki,Mark Yeager
Mark J Daniels
The human zinc transporter ZnT8 (SLC30A8) is expressed primarily in pancreatic β-cells and plays a key function in maintaining the concentration of blood glucose through its role in insulin storage, maturation and secretion. ZnT8 is an aut...
Understanding the structural details of APOBEC3-DNA interactions using graph-based representations [0.03%]
基于图形的表示法用于揭示APOBEC3-DNA相互作用的结构细节
J C-F Ng,F Fraternali
J C-F Ng
Human APOBEC3 (A3; apolipoprotein B mRNA editing catalytic polypeptide-like 3) is a family of seven enzymes involved in generating mutations in nascent reverse transcripts of many retroviruses, as well as the human genome in a range of canc...
The allosteric control mechanism of bacterial glycogen biosynthesis disclosed by cryoEM [0.03%]
利用冷冻电镜揭示细菌糖原生物合成的别构调控机制
Javier O Cifuente,Natalia Comino,Cecilia D&#x;Angelo et al.
Javier O Cifuente et al.
Glycogen and starch are the major carbon and energy reserve polysaccharides in nature, providing living organisms with a survival advantage. The evolution of the enzymatic machinery responsible for the biosynthesis and degradation of such p...
Escherichia coli O176 LPS structure and dynamics: A NMR spectroscopy and MD simulation study [0.03%]
大肠杆菌O176脂多糖的结构和动力学：核磁共振谱学与分子模拟研究
Dhilon S Patel,Pilar Blasco,Göran Widmalm et al.
Dhilon S Patel et al.
A lipopolysaccharide (LPS) molecule is a key component of the bacterial outer membrane used to protect the bacterium and to interact with the environment. To gain insight into its function, the study of the LPS conformation and dynamics at ...
Sarah Leeb,Therese Sörensen,Fan Yang et al.
Sarah Leeb et al.
Random encounters between proteins in crowded cells are by no means passive, but found to be under selective control. This control enables proteome solubility, helps to optimise the diffusive search for interaction partners, and allows for ...
Crystal structure of MOA in complex with a peptide fragment: A protease caught in flagranti [0.03%]
_MOA与肽片段的复合物晶体结构：被捉奸的蛋白酶
Dipankar Manna,Gabriele Cordara,Ute Krengel
Dipankar Manna
The Marasmius oreades agglutinin (MOA) is the holotype of an emerging family of fungal chimerolectins and an active Ca2+/Mn2+-dependent protease, which exhibits a unique papain-like fold with special active site features. Here we investigat...
Isoelectric point-amyloid formation of α-synuclein extends the generality of the solubility and supersaturation-limited mechanism [0.03%]
α-突触核蛋白等电点-淀粉样形成扩展了溶解度和过饱和限制机制的普遍性
Koki Furukawa,Cesar Aguirre,Masatomo So et al.
Koki Furukawa et al.
Proteins in either a native or denatured conformation often aggregate at an isoelectric point (pI), a phenomenon known as pI precipitation. However, only a few studies have addressed the role of pI precipitation in amyloid formation, the cr...
Michael K Fenwick,Steven E Ealick
Michael K Fenwick
Archaebacterial and eukaryotic elongation factor 2 (EF-2) and bacterial elongation factor G (EF-G) are five domain GTPases that catalyze the ribosomal translocation of tRNA and mRNA. In the classical mechanism of activation, GTPases are swi...
Structures of teixobactin-producing nonribosomal peptide synthetase condensation and adenylation domains [0.03%]
产生teixobactin的非核糖体肽合成酶缩合和腺苷酰化结构域的结构
Kemin Tan,Min Zhou,Robert P Jedrzejczak et al.
Kemin Tan et al.
The recently discovered antibiotic teixobactin is produced by uncultured soil bacteria. The antibiotic inhibits cell wall synthesis of Gram-positive bacteria by binding to precursors of cell wall building blocks, and therefore it is thought...
Our vision [0.03%]
我们的愿景
Hélène Hodak
Hélène Hodak