Gustavo Parisi,Nicolas Palopoli,Silvio C E Tosatto et al.
Gustavo Parisi et al.
Every biologist knows that the word protein describes a group of macromolecules essential to sustain life on Earth. As biologists, we are invariably trained under a protein paradigm established since the early twentieth century. However, in...
Erratum to "Thermodynamics and folding landscapes of large proteins from a statistical mechanical model" [Current Research in Structural Biology 1 (2019) 6-12] [0.03%]
“用统计力学模型从理论上研究大型蛋白质的热力学和折叠势能图”一文勘误
Soundhararajan Gopi,Akashnathan Aranganathan,Athi N Naganathan
Soundhararajan Gopi
[This corrects the article DOI: 10.1016/j.crstbi.2019.10.002.]. © 2019 The Author(s).
Published Erratum
Current research in structural biology. 2020 Dec 23:2:239. DOI:10.1016/j.crstbi.2020.12.003 2020
Janina Sprenger,Anda Trifan,Neal Patel et al.
Janina Sprenger et al.
Calmodulin (CaM) is a ubiquitous Ca2+ sensing protein that binds to and modulates numerous target proteins and enzymes during cellular signaling processes. A large number of CaM-target complexes have been identified and structurally charact...
De novo crystal structure determination of double stranded RNA binding domain using only the sulfur anomalous diffraction in SAD phasing [0.03%]
利用SAD相位法仅用硫原子异常衍射数据从头解析双链RNA结合结构域晶体结构
Beatriz Gomes Guimarães,Béatrice Golinelli-Pimpaneau
Beatriz Gomes Guimarães
Single-wavelength anomalous dispersion (SAD)-phasing using sulfur as the unique anomalous scatterer is a powerful method to solve the phase problem in protein crystallography. However, it is not yet widely used by non-expert crystallographe...
Ligand unbinding mechanisms and kinetics for T4 lysozyme mutants from τRAMD simulations [0.03%]
τRAMD模拟的T4溶菌酶突变体配体解离机制及动力学研究
Ariane Nunes-Alves,Daria B Kokh,Rebecca C Wade
Ariane Nunes-Alves
The protein-ligand residence time, τ, influences molecular function in biological networks and has been recognized as an important determinant of drug efficacy. To predict τ, computational methods must overcome the problem that τ often e...
The structures of two salivary proteins from the West Nile vector Culex quinquefasciatus reveal a beta-trefoil fold with putative sugar binding properties [0.03%]
西尼罗病毒载体墨蚊的两种唾液蛋白的结构揭示了具有潜在糖结合特性的β三叶折叠结构
Olivia Kern,Paola Carolina Valenzuela Leon,Apostolos G Gittis et al.
Olivia Kern et al.
Female mosquitoes require blood meals for egg development. The saliva of blood feeding arthropods contains biochemically active molecules, whose anti-hemostatic and anti-inflammatory properties facilitate blood feeding on vertebrate hosts. ...
Cyclohexyl-α maltoside as a highly efficient tool for membrane protein studies [0.03%]
环己基-α-麦芽糖二酸盐作为膜蛋白研究的高效工具
Julie Winkel Missel,Nina Salustros,Eva Ramos Becares et al.
Julie Winkel Missel et al.
Membrane proteins (MPs) constitute a large fraction of the proteome, but exhibit physicochemical characteristics that impose challenges for successful sample production crucial for subsequent biophysical studies. In particular, MPs have to ...
Biochemical and structural characterization of two cif-like epoxide hydrolases from Burkholderia cenocepacia [0.03%]
伯克霍尔德菌基因工程菌株Cepacia复合群的两个cif类表氯醇水合酶的生化和结构特征分析
Noor M Taher,Kelli L Hvorecny,Cassandra M Burke et al.
Noor M Taher et al.
Epoxide hydrolases catalyze the conversion of epoxides to vicinal diols in a range of cellular processes such as signaling, detoxification, and virulence. These enzymes typically utilize a pair of tyrosine residues to orient the substrate e...
Saccharomyces cerevisiae as a superior host for overproduction of prokaryotic integral membrane proteins [0.03%]
模式蛋白细菌型跨膜蛋白的酵母表达宿主筛选及高效分泌表达系统构建
Sarah Spruce Preisler,Anders Drabaek Wiuf,Marc Friis et al.
Sarah Spruce Preisler et al.
Integral membrane proteins (IMPs) constitute ~30% of all proteins encoded by the genome of any organism and Escherichia coli remains the first-choice host for recombinant production of prokaryotic IMPs. However, the expression levels of pro...
Integrated analysis of Shank1 PDZ interactions with C-terminal and internal binding motifs [0.03%]
Shank1 PDZ相互作用的整合分析：尾部和内部结合基序
Muhammad Ali,Mishal Mariam McAuley,Susanne Lüchow et al.
Muhammad Ali et al.
PDZ domains constitute a large family of modular domains that are well-known for binding C-terminal motifs of target proteins. Some of them also bind to internal PDZ binding motifs (PDZbms), but this aspect of the PDZ interactome is poorly ...