3D interaction homology: Hydropathic interaction environments of serine and cysteine are strikingly different and their roles adapt in membrane proteins [0.03%]
三维相互作用同源性：丝氨酸和半胱氨酸的亲水相互作用环境截然不同，它们在膜蛋白中的作用也相应改变
Claudio Catalano,Mohammed H Al Mughram,Youzhong Guo et al.
Claudio Catalano et al.
Atomic-resolution protein structural models are prerequisites for many downstream activities like structure-function studies or structure-based drug discovery. Unfortunately, this data is often unavailable for some of the most interesting a...
Hypervariability of accessible and inaccessible conformational space of proteins [0.03%]
蛋白质可及与不可及构象空间的超变异性
Ashraya Ravikumar,Narayanaswamy Srinivasan
Ashraya Ravikumar
Proteins undergo motions in a range of amplitudes, from domain motions to backbone rotations, leading to changes in (φ,ψ) torsion angles and small-scale bond vibrations and angle bending. Here, we study the extent of variations in (φ,ψ)...
Folded domain charge properties influence the conformational behavior of disordered tails [0.03%]
折叠结构的电荷特性影响无序尾部的构象行为
Ishan Taneja,Alex S Holehouse
Ishan Taneja
Intrinsically disordered proteins and protein regions (IDRs) make up around 30% of the human proteome where they play essential roles in dictating and regulating many core biological processes. While IDRs are often studied as isolated domai...
Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure [0.03%]
人乙酰胆碱酯酶与底物类似物4K-TMA结合的室温晶体学研究：迈向中子结构的研究
Oksana Gerlits,Matthew P Blakeley,David A Keen et al.
Oksana Gerlits et al.
Acetylcholinesterase (AChE) catalyzes hydrolysis of acetylcholine thereby terminating cholinergic nerve impulses for efficient neurotransmission. Human AChE (hAChE) is a target of nerve agent and pesticide organophosphorus compounds that co...
Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis [0.03%]
皮质醇合成酶CYP11B1的底物结合位点空间受限，限制了多种羟基化并阻碍了醛固酮的合成
Kuniaki Mukai,Hiroshi Sugimoto,Katsumasa Kamiya et al.
Kuniaki Mukai et al.
Human cytochromes P45011β (CYP11B1) and P450aldo (CYP11B2) are monooxygenases that synthesize cortisol through steroid 11β-hydroxylation and aldosterone through a three-step process comprising 11β-hydroxylation and two 18-hydroxylations,...
Amélie Barozet,Pablo Chacón,Juan Cortés
Amélie Barozet
Loops are key components of protein structures, involved in many biological functions. Due to their conformational variability, the structural investigation of loops is a difficult topic, requiring a combination of experimental and computat...
Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1 [0.03%]
靶向癌症的蝎毒ClTx与血管内皮生长因子受体神经纤毛蛋白-1结合的结构基础
Gagan Sharma,Carolyne B Braga,Kai-En Chen et al.
Gagan Sharma et al.
Chlorotoxin (ClTx) is a 36-residue disulfide-rich peptide isolated from the venom of the scorpion Leiurus quinquestriatus. This peptide has been shown to selectively bind to brain tumours (gliomas), however, with conflicting reports regardi...
Structure of the Mycobacterium tuberculosis c PknF and conformational changes induced in forkhead-associated regulatory domains [0.03%]
分枝杆菌激酶PknF的结构及其对叉头框相关调控结构域构象变化的影响研究
Sindy Cabarca,Maximilia Frazão de Souza,Andrew Albert de Oliveira et al.
Sindy Cabarca et al.
Mycobacterium tuberculosis (Mtb) has 11 Serine-Threonine Protein Kinases (STPK) that control numerous physiological processes, including cell growth, cell division, metabolic flow, and transcription. PknF is one of the 11 Mtb STPKs that has...
Peptide bond planarity constrains hydrogen bond geometry and influences secondary structure conformations [0.03%]
肽键平面性限制氢键几何形状并影响二级结构构象
Kuan Pern Tan,Khushboo Singh,Anirban Hazra et al.
Kuan Pern Tan et al.
An extensive database study of hydrogen bonds in different protein environments showed systematic variations in donor-acceptor-acceptor antecedent angle (Ĥ) and donor-acceptor distance. Protein environments were characterized by depth (dis...
Priming mycobacterial ESX-secreted protein B to form a channel-like structure [0.03%]
分泌蛋白B的预触发以形成通道结构
Abril Gijsbers,Vanesa Vinciauskaite,Axel Siroy et al.
Abril Gijsbers et al.
ESX-1 is a major virulence factor of Mycobacterium tuberculosis, a secretion machinery directly involved in the survival of the microorganism from the immune system defence. It disrupts the phagosome membrane of the host cell through a cont...