Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B [0.03%]
一对识别难辨梭菌毒素B糖基转移酶结构域不同表位的单克隆抗体的新结构见解
Jinyu Liu,Michael Kothe,Jianxin Zhang et al.
Jinyu Liu et al.
Clostridium difficile toxins are the primary causative agents for hospital-acquired diarrhea and pseudomembranous colitis. Numerous monoclonal antibodies (mAbs) targeting different domains of Clostridium difficile toxin have been reported. ...
Crystal structure of plasmoredoxin, a redox-active protein unique for malaria parasites [0.03%]
血红素还原蛋白 plasmoredoxin的晶体结构是一项独特的疟原虫蛋白质
Karin Fritz-Wolf,Jochen Bathke,Stefan Rahlfs et al.
Karin Fritz-Wolf et al.
Plasmoredoxin is a 22 kDa thiol-disulfide oxidoreductase involved in cellular redox regulatory processes and antioxidant defense. The 1.6 Å structure of the protein, solved via X-ray crystallography, adopts a modified thioredoxin fold....
Molecular docking and simulation of IcaC protein as O-succinyltransferase function in staphylococcus epidermidis biofilm formation [0.03%]
IcaC蛋白作为表皮葡萄球菌生物被膜形成中O-琥珀酰转移酶功能的分子对接及模拟研究
Ramachandira Prabu,Amaresh Mohanty,Susmida Seni Balakrishnan et al.
Ramachandira Prabu et al.
Intercellular adhesion (IcaADBC) operon is necessary for PNAG (Polyβ-1,6-N-acetyl-D-glucosamine) biosynthesis of biofilm formation in Staphylococcus epidermidis. IcaC protein has a wide range of functions in terms of growth phase variation...
Bridging the N-terminal and middle domains in FliG of the flagellar rotor [0.03%]
连接旗ellar旋转电机中的FliG蛋白N端结构域和中部结构域
Dagnija Tupiņa,Alexander Krah,Jan K Marzinek et al.
Dagnija Tupiņa et al.
Flagella are necessary for bacterial movement and contribute to various aspects of virulence. They are complex cylindrical structures built of multiple molecular rings with self-assembly properties. The flagellar rotor is composed of the MS...
The sulfoquinovosyl glycerol binding protein SmoF binds and accommodates plant sulfolipids [0.03%]
硫代四糖醇甘油酯结合蛋白SmoF的底物特异性和结合机制
Alexander J D Snow,Mahima Sharma,James P Lingford et al.
Alexander J D Snow et al.
Sulfoquinovose (SQ) is the anionic headgroup of the ubiquitous plant sulfolipid, sulfoquinovosyl diacylglycerol (SQDG). SQDG can undergo delipidation to give sulfoquinovosyl glycerol (SQGro) and further glycoside cleavage to give SQ, which ...
Energy landscape of the SARS-CoV-2 reveals extensive conformational heterogeneity [0.03%]
SARS-CoV-2的能量景观揭示了广泛的构象异质性
Ghoncheh Mashayekhi,John Vant,Abhigna Polavarapu et al.
Ghoncheh Mashayekhi et al.
Cryo-electron microscopy (cryo-EM) has produced a number of structural models of the SARS-CoV-2 spike, already prompting biomedical outcomes. However, these reported models and their associated electrostatic potential maps represent an unkn...
Mutations in human SARS-CoV-2 spike proteins, potential drug binding and epitope sites for COVID-19 therapeutics development [0.03%]
针对COVID-19治疗的人类SARS-CoV-2刺突蛋白突变、潜在药物结合和表位位点的开发研究论文标题 перевод成中文是：人类SARS-CoV-2刺突蛋白变异体中潜在的药物结合与抗原表位位点的鉴定以促进COVID-19治疗的发展
Kunchur Guruprasad
Kunchur Guruprasad
The comparison of 303,250 human SARS-CoV-2 spike protein sequences with the reference protein sequence Wuhan-Hu-1, showed ∼96.5% of the spike protein sequence has undergone the mutations till date, since outbreak of the COVID-19 pandemic d...
Transactivation domain of Adenovirus Early Region 1A (E1A): Investigating folding dynamics and aggregation [0.03%]
腺病毒早期区域1A（E1A）的转激活域：研究折叠动力学和聚集现象
Nitin Sharma,Kundlik Gadhave,Prateek Kumar et al.
Nitin Sharma et al.
Transactivation domain of Adenovirus Early region 1A (E1A) oncoprotein is an intrinsically disordered molecular hub protein. It is involved in binding to different domains of human cell transcriptional co-activators such as retinoblastoma (...
Federica Centorrino,Blaž Andlovic,Peter Cossar et al.
Federica Centorrino et al.
The modulation of protein-protein interactions (PPIs) has developed into a well-established field of drug discovery. Despite the advances achieved in the field, many PPIs are still deemed as 'undruggable' targets and the design of PPIs stab...
Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl ester as ATP-competitive inhibitors of BRAF: A bioinformatics study [0.03%]
Withaferin-A、Withanone和咖啡酸苯乙酯作为BRAF的ATP竞争性抑制剂的潜力：一项生物信息学研究
Vidhi Malik,Vipul Kumar,Sunil C Kaul et al.
Vidhi Malik et al.
Serine/threonine-protein kinase B-raf (BRAF) plays a significant role in regulating cell division and proliferation through MAPK/ERK pathway. The constitutive expression of wild-type BRAF (BRAFWT) and its mutant forms, especially V600E (BRA...