Proteomic analysis reveals dexamethasone rescues matrix breakdown but not anabolic dysregulation in a cartilage injury model [0.03%]
蛋白组学分析揭示了地塞米松可挽救软骨损伤模型中的基质降解但不能调节失凋的合成代谢
Rebecca Mae Black,Yang Wang,André Struglics et al.
Rebecca Mae Black et al.
Objectives: In this exploratory study, we used discovery proteomics to follow the release of proteins from bovine knee articular cartilage in response to mechanical injury and cytokine treatment. We also studied the effec...
Knee joint biomechanics of simplified 24 Tai Chi forms and association with pain in individuals with knee osteoarthritis: A pilot study [0.03%]
简化24式太极拳动作对膝关节生物力学的影响及与膝骨关节炎疼痛的关系：一项试点研究
Feng Yang,Wei Liu
Feng Yang
Objectives: Tai Chi (TC) is a multi-beneficial exercise for improving health and function in knee osteoarthritis (OA). Biomechanical insights of 24 TC forms at the knee joint are not well understood. We aimed to examine k...
Biomechanical joint loading mechanism of Tai Chi gait in individuals with knee osteoarthritis: A pilot simulation study [0.03%]
膝关节骨关节炎患者太极拳步态生物力学关节负荷机制的模拟研究
Paulien Esther Roos,Austin Mituniewicz,Wei Liu
Paulien Esther Roos
Objectives: Tai Chi (TC) has shown beneficial effects on joint function in knee osteoarthritis (OA). Biomechanical mechanisms of knee joint contact load (JCL) and muscle activations during TC are less understood. The purp...
Relating MR relaxation times of ex vivo meniscus to tissue degeneration through comparison with histopathology [0.03%]
基于与组织病理学对比的半月板离体磁共振弛豫时间与退变的关系研究
Emma Einarsson,Jonas Svensson,Elin Folkesson et al.
Emma Einarsson et al.
Background: Quantitative magnetic resonance imaging (MRI), e.g. relaxation parameter mapping, may be sensitive to structural and compositional tissue changes, and could potentially be used to non-invasively detect and mon...
Jean W Liew,Seoyoung C Kim,Christine Peloquin et al.
Jean W Liew et al.
Background: Anti-nerve growth factor (NGF) has shown promise for osteoarthritis (OA) pain efficacy, but an unanticipated joint safety signal occurred in trials. To what extent this was related to OA natural history, or wa...
Prevalence of Undiagnosed Subchondral Insufficiency Fractures of the Knee in Middle Age Adults with Knee Pain and Suspected Meniscal Tear [0.03%]
膝关节疼痛伴半月板损伤嫌疑的中年人群中的未诊断股骨头下骨梗死骨折患病率
Jamie L Huizinga,Nehal Shah,Stacy E Smith et al.
Jamie L Huizinga et al.
Objective: Symptomatic knee osteoarthritis (OA) and meniscal tear are often treated with weight-bearing exercises and without ordering advanced imaging (e.g. MRI). This may lead to missed diagnoses of subchondral insuffic...
Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage [0.03%]
白介素13（IL-13）调节的软骨保护型金属基质蛋白酶ADAM15在老年软骨中的表达降低
C Y Yang,A Chanalaris,S Bonelli et al.
C Y Yang et al.
Objective: The adamalysin metalloproteinase 15 (ADAM15) has been shown to protect against development of osteoarthritis in mice. Here, we have investigated factors that control ADAM15 levels in cartilage. ...
Examining the role of transient receptor potential canonical 5 (TRPC5) in osteoarthritis [0.03%]
瞬时受体电位Canonical 5通道在骨关节炎发病机制中的功能作用研究
João de Sousa Valente,Khadija M Alawi,Patrik Keringer et al.
João de Sousa Valente et al.
Introduction: Osteo-arthritis (OA) involves joint degradation and usually pain; with mechanisms poorly understood and few treatment options. There is evidence that the transient receptor potential canonical 5 (TRPC5) mRNA...
Comparison of LABORAS with static incapacitance testing for assessing spontaneous pain behaviour in surgically-induced murine osteoarthritis [0.03%]
LABORAS与静态无能测试在评估手术诱导的小鼠骨关节炎自发性疼痛行为方面的比较
Isabell S von Loga,Jadwiga Miotla-Zarebska,Yi-Shu Huang et al.
Isabell S von Loga et al.
Objective: Evoked responses following mechanical or thermal stimulation are typically used to assess pain behaviour in murine osteoarthritis (OA). However, there is no consensus on how best to measure spontaneous pain beh...
The association between comorbidity and physical activity levels in people with osteoarthritis: Secondary analysis from two randomised controlled trials [0.03%]
共病与骨关节炎患者体力活动水平之间的关联：两项随机对照试验的次级分析结果
Sarah McKevitt,Emma Healey,Clare Jinks et al.
Sarah McKevitt et al.
Objective: To determine whether comorbidity presence, frequency or type is associated with Physical Activity (PA) levels in people with Osteoarthritis (OA). ...