Data sharing across osteoarthritis research groups and disciplines: Opportunities and challenges [0.03%]
骨关节炎研究小组和学科之间的数据共享：机遇与挑战
Jill Evans,Rebecca I Hamilton,Paul Biggs et al.
Jill Evans et al.
Background: Osteoarthritis is a heterogeneous condition characterised by a wide variety of factors and represents a worldwide healthcare challenge. There are multiple clinical and research specialisms involved in the diag...
Osteoarthritis Data Integration Portal (OsteoDIP): A web-based gene and non-coding RNA expression database [0.03%]
骨关节炎数据集成门户(OsteoDIP)：基于网络的基因和非编码RNA表达数据库
Chiara Pastrello,Mark Abovsky,Richard Lu et al.
Chiara Pastrello et al.
Objective: OsteoDIP aims to collect and provide, in a simple searchable format, curated high throughput RNA expression data related to osteoarthritis. Des...
Inhibition of transforming growth factor-β in osteoarthritis. Discrepancy with reduced TGFβ signaling in normal joints [0.03%]
骨性关节炎中转化生长因子-β的抑制作用。与正常关节中减少的TGFβ信号传导不符。
为了更符合中文表达习惯，可以调整为：
在骨性关节炎中的转化生长因子-β抑制作用。与正常关节中降低的TGFβ信号不一致。
Peter M van der Kraan
Peter M van der Kraan
Objective: Transforming growth factor-β (TGFβ) is a pleiotropic cytokine that is central in the regulation of joint health and disease. Inhibition of TGFβ activity/signaling in experimental osteoarthritis (OA) has been...
In vivo mechanotransduction: Effect of acute exercise on the metabolomic profiles of mouse synovial fluid [0.03%]
体内力学转导：急性运动对小鼠滑液的代谢组学特征的影响
Alyssa K Hahn,Rachel A Rawle,Brian Bothner et al.
Alyssa K Hahn et al.
Objective: Exercise is known to induce beneficial effects in synovial joints. However, the mechanisms underlying these are unclear. Synovial joints experience repeated mechanical loading during exercise. These mechanical ...
Jackie L Whittaker,Linda K Truong,Trish Silvester-Lee et al.
Jackie L Whittaker et al.
Objective: Assess the feasibility of a virtually-delivered, physiotherapist-guided knee health program (SOAR) that targets self-management of knee health and osteoarthritis risk after an activity-related knee injury. ...
Rheumatoid arthritis chondrocytes produce increased levels of pro-inflammatory proteins [0.03%]
类风湿性关节炎软骨细胞产生更高水平的促炎蛋白
Karin Önnheim,Shan Huang,Alexander Strid Holmertz et al.
Karin Önnheim et al.
Objective: To investigate whether articular chondrocytes from rheumatoid arthritis (RA) patients have acquired a proinflammatory phenotype. Method: ...
Effect of knee joint loading on chondrocyte mechano-vulnerability and severity of post-traumatic osteoarthritis induced by ACL-injury in mice [0.03%]
膝关节加载对由ACL损伤诱导的小鼠创伤后骨关节炎的软骨细胞力学生存能力和严重性的影响
Alexander Kotelsky,Anissa Elahi,Can Nejat Yigit et al.
Alexander Kotelsky et al.
Objective: The objective of this study is to understand the role of altered in vivo mechanical environments in knee joints post anterior cruciate ligament (ACL)-injury in chondrocyte vulnerability against mechanical stimu...
Feasibility of personalised hip load modification using real-time biofeedback in hip osteoarthritis: A pilot study [0.03%]
个性化实时生物反馈在髋关节骨关节炎中减少髋关节负荷的应用前景：一项初步研究
Laura E Diamond,Daniel Devaprakash,Bradley Cornish et al.
Laura E Diamond et al.
Objective: (i) Compare the feasibility of three load modification strategies to immediately increase hip contact force in people with hip osteoarthritis (OA) using real-time visual biofeedback during walking, and (ii) pro...
A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress [0.03%]
探索OA风险基因对高生理机械应力反应的人体体外3D新软骨模型
Ritchie G M Timmermans,Niek G C Bloks,Margo Tuerlings et al.
Ritchie G M Timmermans et al.
Objective: Due to the complexity and heterogeneity of osteoarthritis (OA) pathophysiology, studying the interaction between intrinsic molecular changes in chondrocytes after hyper-physiological mechanical stress (MS) and ...
Fast quantitative bone marrow lesion measurement on knee MRI for the assessment of osteoarthritis [0.03%]
膝关节MRI中快速定量骨髓病变测量在骨关节炎评估中的应用
Frank Preiswerk,Meera S Sury,Jeremy R Wortman et al.
Frank Preiswerk et al.
Objective: Knee osteoarthritis (KOA) is a prevalent disease with a high economic and social cost. Magnetic resonance imaging (MRI) can be used to visualize many KOA-related structures including bone marrow lesions (BMLs),...