Foot and ankle pain and risk of incident knee osteoarthritis and knee pain: Data from the Multicentre Osteoarthritis Study [0.03%]
足踝痛与膝骨关节炎及膝痛发病风险的关系——多中心骨关节炎研究的数据分析
Thomas A Perry,Neil A Segal,Catherine Bowen et al.
Thomas A Perry et al.
Objectives: To examine whether foot and/or ankle pain increases the risk of knee OA. Design: We utilised longitudinal data from the Mul...
Mouse microRNA signatures in joint ageing and post-traumatic osteoarthritis [0.03%]
小鼠关节老化和创伤后骨关节炎的微RNA特征分析研究
Catarina I G D Castanheira,James R Anderson,Yongxiang Fang et al.
Catarina I G D Castanheira et al.
Objective: This study investigated mice serum and joint microRNA expression profiles in ageing and osteoarthritis to elucidate the role of microRNAs in the development and progression of disease, and provide biomarkers fo...
EFFECTS OF SOLUTE SIZE AND TISSUE COMPOSITION ON MOLECULAR AND MACROMOLECULAR DIFFUSIVITY IN HUMAN KNEE CARTILAGE [0.03%]
人类膝关节软骨中溶质尺寸和组织成分对分子及大分子扩散系数的影响
Francesco Travascio,Sabrina Valladares-Prieto,Alicia R Jackson
Francesco Travascio
Objective: Articular cartilage is an avascular tissue. Accordingly, diffusivity represents a fundamental transport mechanism for nutrients and other molecular signals regulating its cell metabolism and maintenance of the ...
Monica Zell,Thanda Aung,Marian Kaldas et al.
Monica Zell et al.
Objective: To describe the characteristics of calcium pyrophosphate (CPP) crystal size and morphology under compensated polarized light microscopy (CPLM). Secondarily, to describe CPP crystals seen only with digital enhan...
Proteomic analysis reveals dexamethasone rescues matrix breakdown but not anabolic dysregulation in a cartilage injury model [0.03%]
蛋白组学分析揭示了地塞米松可挽救软骨损伤模型中的基质降解但不能调节失凋的合成代谢
Rebecca Mae Black,Yang Wang,André Struglics et al.
Rebecca Mae Black et al.
Objectives: In this exploratory study, we used discovery proteomics to follow the release of proteins from bovine knee articular cartilage in response to mechanical injury and cytokine treatment. We also studied the effec...
Knee joint biomechanics of simplified 24 Tai Chi forms and association with pain in individuals with knee osteoarthritis: A pilot study [0.03%]
简化24式太极拳动作对膝关节生物力学的影响及与膝骨关节炎疼痛的关系：一项试点研究
Feng Yang,Wei Liu
Feng Yang
Objectives: Tai Chi (TC) is a multi-beneficial exercise for improving health and function in knee osteoarthritis (OA). Biomechanical insights of 24 TC forms at the knee joint are not well understood. We aimed to examine k...
Biomechanical joint loading mechanism of Tai Chi gait in individuals with knee osteoarthritis: A pilot simulation study [0.03%]
膝关节骨关节炎患者太极拳步态生物力学关节负荷机制的模拟研究
Paulien Esther Roos,Austin Mituniewicz,Wei Liu
Paulien Esther Roos
Objectives: Tai Chi (TC) has shown beneficial effects on joint function in knee osteoarthritis (OA). Biomechanical mechanisms of knee joint contact load (JCL) and muscle activations during TC are less understood. The purp...
Relating MR relaxation times of ex vivo meniscus to tissue degeneration through comparison with histopathology [0.03%]
基于与组织病理学对比的半月板离体磁共振弛豫时间与退变的关系研究
Emma Einarsson,Jonas Svensson,Elin Folkesson et al.
Emma Einarsson et al.
Background: Quantitative magnetic resonance imaging (MRI), e.g. relaxation parameter mapping, may be sensitive to structural and compositional tissue changes, and could potentially be used to non-invasively detect and mon...
Jean W Liew,Seoyoung C Kim,Christine Peloquin et al.
Jean W Liew et al.
Background: Anti-nerve growth factor (NGF) has shown promise for osteoarthritis (OA) pain efficacy, but an unanticipated joint safety signal occurred in trials. To what extent this was related to OA natural history, or wa...
Prevalence of Undiagnosed Subchondral Insufficiency Fractures of the Knee in Middle Age Adults with Knee Pain and Suspected Meniscal Tear [0.03%]
膝关节疼痛伴半月板损伤嫌疑的中年人群中的未诊断股骨头下骨梗死骨折患病率
Jamie L Huizinga,Nehal Shah,Stacy E Smith et al.
Jamie L Huizinga et al.
Objective: Symptomatic knee osteoarthritis (OA) and meniscal tear are often treated with weight-bearing exercises and without ordering advanced imaging (e.g. MRI). This may lead to missed diagnoses of subchondral insuffic...