Effect of knee joint loading on chondrocyte mechano-vulnerability and severity of post-traumatic osteoarthritis induced by ACL-injury in mice [0.03%]
膝关节加载对由ACL损伤诱导的小鼠创伤后骨关节炎的软骨细胞力学生存能力和严重性的影响
Alexander Kotelsky,Anissa Elahi,Can Nejat Yigit et al.
Alexander Kotelsky et al.
Objective: The objective of this study is to understand the role of altered in vivo mechanical environments in knee joints post anterior cruciate ligament (ACL)-injury in chondrocyte vulnerability against mechanical stimu...
Feasibility of personalised hip load modification using real-time biofeedback in hip osteoarthritis: A pilot study [0.03%]
个性化实时生物反馈在髋关节骨关节炎中减少髋关节负荷的应用前景：一项初步研究
Laura E Diamond,Daniel Devaprakash,Bradley Cornish et al.
Laura E Diamond et al.
Objective: (i) Compare the feasibility of three load modification strategies to immediately increase hip contact force in people with hip osteoarthritis (OA) using real-time visual biofeedback during walking, and (ii) pro...
A human in vitro 3D neo-cartilage model to explore the response of OA risk genes to hyper-physiological mechanical stress [0.03%]
探索OA风险基因对高生理机械应力反应的人体体外3D新软骨模型
Ritchie G M Timmermans,Niek G C Bloks,Margo Tuerlings et al.
Ritchie G M Timmermans et al.
Objective: Due to the complexity and heterogeneity of osteoarthritis (OA) pathophysiology, studying the interaction between intrinsic molecular changes in chondrocytes after hyper-physiological mechanical stress (MS) and ...
Fast quantitative bone marrow lesion measurement on knee MRI for the assessment of osteoarthritis [0.03%]
膝关节MRI中快速定量骨髓病变测量在骨关节炎评估中的应用
Frank Preiswerk,Meera S Sury,Jeremy R Wortman et al.
Frank Preiswerk et al.
Objective: Knee osteoarthritis (KOA) is a prevalent disease with a high economic and social cost. Magnetic resonance imaging (MRI) can be used to visualize many KOA-related structures including bone marrow lesions (BMLs),...
Non-surgical management of hip and knee osteoarthritis; comparison of ACR/AF and OARSI 2019 and VA/DoD 2020 guidelines [0.03%]
非手术治疗髋膝骨关节炎；比较ACR/AF和OARSI 2019以及VA/DoD 2020指南
Marwa Sabha,Marc C Hochberg
Marwa Sabha
Background and objectives: Osteoarthritis (OA) is the most common form of arthritis and is associated with significant morbidity and mortality. There are several available recently updated guidelines for the management of...
Genipin does not reduce the initiation or propagation of microcracks in collagen networks of cartilage [0.03%]
苦杏仁素不会减少软骨胶原网络中微裂纹的形成或传播
Stephany Santos,Corey P Neu,James J Grady et al.
Stephany Santos et al.
Objective: We recently initiated microcracks, i.e. micron-scale cracks in the collagen networks of cartilage, using both single low-energy impacts and unconfined, cyclic compressions. We also tracked the propagation of mi...
Sustained delivery of the bone morphogenetic proteins BMP-2 and BMP-7 for cartilage repair and regeneration in osteoarthritis [0.03%]
骨形态发生蛋白BMP-2和BMP-7的持续传递用于骨关节炎的软骨修复和再生
Ciara Whitty,Christian Pernstich,Charlotte Marris et al.
Ciara Whitty et al.
Objective: Attempts to utilise growth factors (GF) such as bone morphogenic proteins (BMPs) to treat osteoarthritis (OA) in the clinic have not secured widespread adoption. However, the novel crystalline GF formulation ca...
Expedited gene delivery for osteochondral defect repair in a rabbit knee model: A one-year investigation [0.03%]
兔子膝关节模型中用于软骨骨缺损修复的加速基因传递：为期一年的研究
Christopher V Nagelli,Rodolfo E De La Vega,Michael Coenen et al.
Christopher V Nagelli et al.
Objective: To evaluate a single-step, gene-based procedure for repairing osteochondral lesions. Design: Osteochondral lesions were crea...
Proteomic Clustering Reveals the Kinetics of Disease Biomarkers in Bovine and Human Models of Post-Traumatic Osteoarthritis [0.03%]
基于蛋白质组学的聚类分析揭示了创伤后骨关节炎疾病标志物的动力学特征：牛和人模型的研究
Rebecca Mae Black,Yang Wang,André Struglics et al.
Rebecca Mae Black et al.
Objectives: In this study, we apply a clustering method to proteomic data sets from bovine and human models of post-traumatic osteoarthritis (PTOA) to distinguish clusters of proteins based on their kinetics of release fr...
Minimally Invasive Polarization Sensitive Optical Coherence Tomography (PS-OCT) for assessing Pre-OA, a pilot study on technical feasibility [0.03%]
用于评估早期关节炎的极小创口型偏振敏感光学相干断层扫描（PS-OCT）技术可行性试点研究
S Martin,C Rashidifard,D Norris et al.
S Martin et al.
Objective: Efforts to develop chondroprotective approaches to halt osteoarthritis (OA) progression have recently increased. Current imaging techniques are critical in managing advanced OA, but greater resolution is needed...