Applications of transcriptomics in support of drug development for osteoarthritis [0.03%]
转录组学在骨关节炎药物开发中的应用
Hélène Kaplon,Yufei Luo,Frédéric De Ceuninck et al.
Hélène Kaplon et al.
Objective: Understanding the heterogeneity and pathophysiology of osteoarthritis (OA) is critical to support the development of tailored disease-modifying treatments. To this aim, transcriptomics tools are highly relevant...
Frequency of MRI-detected peripheral osteoarthritis in athletes during the Summer Olympics in Rio 2016 [0.03%]
里约2016夏季奥运会运动员MRI检出的外周骨关节炎的频率
Alexander Merritt,Frank W Roemer,Rafael Heiss et al.
Alexander Merritt et al.
Objective: To describe the frequency and severity of magnetic resonance imaging (MRI) based peripheral osteoarthritis (OA) in athletes during the Rio de Janeiro 2016 Olympic Games. ...
Targeted phospholipidomic analysis of synovial fluid as a tool for osteoarthritis deep phenotyping [0.03%]
靶向磷脂质谱分析作为骨关节炎深度表型的工具应用于滑液中
Beatriz Rocha,Anna Illiano,Valentina Calamia et al.
Beatriz Rocha et al.
Objective: The aim of this study was to carry out a targeted phospholipidomic analysis on synovial fluid (SF) from patients with different grades of osteoarthritis (OA) and controls, in order to search for specific phosph...
Human amniotic membrane modulates Wnt/β-catenin and NF-κβ signaling pathways in articular chondrocytes in vitro [0.03%]
人羊膜在体外调节软骨细胞中的Wnt / β-连环蛋白和NF-κβ信号传导途径
Connie Chung,Michelle Massee,Thomas J Koob
Connie Chung
Objective: Inflammation, catabolism, and hypertrophy in chondrocytes play a central role in osteoarthritis (OA). The Wnt/β-catenin and NF-κβ pathways contribute to these degradative processes. This in vitro study evalu...
Possible role of MRI-detected osteophytes as a predictive biomarker for development of osteoarthritis of the knee: A study using data from the Osteoarthritis Initiative [0.03%]
MRI检测的骨赘在预测膝骨关节炎发展中的生物标记物作用：一项使用骨关节炎倡议数据的研究
Ryosuke Tozawa,Yuya Ogawa,Yusuke Minamoto et al.
Ryosuke Tozawa et al.
Objective: To elucidate the possible role of MRI-detected osteophytes as a predictive imaging biomarker for knee osteoarthritis (KOA). Design: ...
Safety and pharmacokinetics of EP-104IAR (sustained-release fluticasone propionate) in knee osteoarthritis: A randomized, double-blind, placebo-controlled phase 1 trial [0.03%]
膝关节骨性关节炎患者中EP-104IAR（缓释氟替卡松）的安全性和药代动力学：一项随机双盲安慰剂对照一期临床试验
Amanda Malone,James Price,Nicola Price et al.
Amanda Malone et al.
Objective: EP-104IAR is a novel, sustained-release, intra-articular (IA) formulation of the corticosteroid fluticasone propionate (FP), in development for the treatment of osteoarthritis (OA) pain. This study evaluated th...
Characteristics of persons with hand osteoarthritis visiting complementary and alternative medicine providers [0.03%]
访问补充和替代医学提供者的手骨关节炎患者的特征
Marianne Ulrichsen,Agnete Egilsdatter Kristoffersen,Ingvild Kjeken et al.
Marianne Ulrichsen et al.
Objective: To examine the frequency of Complementary and Alternative Medicine (CAM) in a hand osteoarthritis (OA) population, and to compare demographic and clinical characteristics between persons with hand OA visiting v...
The state of trial registrations in the field of Orthopaedics in years 2015-2020. A meta-epidemiological study [0.03%]
2015-2020年间骨科试验注册的状态。一项元流行病学研究
Goris Nazari,Dion Diep,Joy C MacDermid
Goris Nazari
Objective: To assess the extent and trends in registration of Orthopaedic randomized clinical trials (RCTs) between 2015 and 2020. Design: ...
Understanding the management of osteoarthritis: A qualitative study of GPs and orthopaedic surgeons in Tasmania, Australia [0.03%]
理解骨关节炎的管理：对澳大利亚塔斯马尼亚州全科医生和骨科外科医生的定性研究
Laura Sutton,Kim Jose,Alana Betzold et al.
Laura Sutton et al.
Objective: Using a qualitative design this study aimed to 1) explore the attitudes towards and understanding of osteoarthritis (OA) held by Tasmanian general practitioners (GPs) and orthopaedic surgeons, 2) gain a deeper ...
Disuse histological changes of an unloading environment on joint components in rat knee joints [0.03%]
去除负载环境中大鼠膝关节组成成分的废用组织学变化
Ikufumi Takahashi,Taro Matsuzaki,Hiroshi Kuroki et al.
Ikufumi Takahashi et al.
Objectives: To clarify the effects of mechanical unloading on joint components, including the articular cartilage by knee compartments, synovial membrane, and the infrapatellar fat pad (IFP), using a hindlimb suspension r...