The effect of vitamin K insufficiency on histological and structural properties of knee joints in aging mice [0.03%]
维生素K不足对老年小鼠膝关节组织结构特性的影响
M Kyla Shea,Sarah L Booth,Stephanie G Harshman et al.
M Kyla Shea et al.
Objective: While a role for vitamin K in maintaining joint tissue homeostasis has been proposed based on the presence of vitamin K dependent proteins in cartilage and bone, it is not clear if low vitamin K intake is causa...
Effect of autotaxin inhibition in a surgically-induced mouse model of osteoarthritis [0.03%]
手术诱导的骨关节炎小鼠模型中自身吸引素抑制的作用
Poulami Datta,Rajiv Gandhi,Sayaka Nakamura et al.
Poulami Datta et al.
Objective: Osteoarthritis (OA) is a degenerative joint disease with no approved disease modifying therapy. The enzyme autotaxin (ATX) converts lysophoshatidylcholine analogues to lysophosphatidic acid. Systemic inhibition...
Tissue distribution of sprifermin (recombinant human fibroblast growth factor 18) in the rat following intravenous and intra-articular injection [0.03%]
静脉注射和关节内注射sprifermin（重组人成纤维细胞生长因子18）后大鼠的组织分布情况
C H Ladel,L Barbero,S Riva et al.
C H Ladel et al.
Objective: Fibroblast growth factor 18 (FGF18) is involved in chondrogenesis and articular cartilage repair. We investigated tissue distribution and pharmacokinetics of radioactive [3H]sprifermin, a recombinant human FGF1...
Yunyun Luo,Yi He,Morten Karsdal et al.
Yunyun Luo et al.
Objective: Type II collagen is the most abundant protein of articular cartilage. The urinary cross-linked C-terminal telopeptide of type II collagen (uCTX-II) is a matrix metalloproteinase (MMP) cleaved fragment and may b...
New insight on the subchondral bone and cartilage functional unit: Bone mineral density and cartilage thickness are spatially correlated in non-osteoarthritic femoral condyles [0.03%]
软骨下骨和软骨功能单元的新见解：非骨关节炎股骨髁的骨矿物质密度和软骨厚度空间相关
Hugo Babel,Patrick Omoumi,Thomas P Andriacchi et al.
Hugo Babel et al.
Objective: This study aimed to improve our understanding of the relationship between bone and cartilage by characterizing the morphological coupling between these mechanosensitive tissues exposed to the same mechanical en...
Choosing interventions for hip or knee osteoarthritis - What matters to stakeholders? A mixed-methods study [0.03%]
选择干预措施治疗髋关节或膝关节骨关节炎-相关方重视的因素？一项混合方法研究
Jason Chua,Andrew M Briggs,Paul Hansen et al.
Jason Chua et al.
Objective: To identify what factors drive choices among interventions for hip or knee osteoarthritis (OA), and to rank the characteristics of interventions. ...
Patients with osteoarthritis are least likely to receive lifestyle advice compared with patients with diabetes and hypertension: A national health survey study from Denmark [0.03%]
与糖尿病及高血压患者相比，骨关节炎患者最少会获得生活上的建议：来自丹麦的国家健康调查研究
Linda Baumbach,Ewa M Roos,Jesper Lykkegaard et al.
Linda Baumbach et al.
Objectives: To investigate the association between having osteoarthritis (OA), hypertension, or diabetes, either alone or in combination, and receiving guideline-recommended exercise or weight-reduction advice. ...
Characterization of OA development between sexes in the rat medial meniscal transection model [0.03%]
大鼠内侧半月板切除模型中OA发展的性别差异特征研究
Krishna A Pucha,Jay M McKinney,Julia M Fuller et al.
Krishna A Pucha et al.
Objective: Osteoarthritis (OA) is a chronic degenerative disease of the joints characterized by articular cartilage degradation. While clear sex differences exist in human OA development, most pre-clinical research has be...
The use of technology in the subcategorisation of osteoarthritis: a Delphi study approach [0.03%]
技术在骨关节炎亚分类中的应用：德菲研究法
Claire Mennan,Timothy Hopkins,Alastair Channon et al.
Claire Mennan et al.
Objective: This UK-wide OATech Network + consensus study utilised a Delphi approach to discern levels of awareness across an expert panel regarding the role of existing and novel technologies in osteoarthritis research. T...
Implementing a national first-line management program for moderate-severe knee osteoarthritis in Australia: A budget impact analysis focusing on knee replacement avoidance [0.03%]
在澳大利亚实施国家中重度膝骨关节炎一线管理方案：侧重于避免进行膝关节置换的预算影响分析
Ilana N Ackerman,Søren T Skou,Ewa M Roos et al.
Ilana N Ackerman et al.
Objective: To model potential cost savings associated with implementing a first-line management program for moderate-severe knee osteoarthritis (OA) at a national level in Australia. ...