Determinants of six-minute walk test performance in individuals with knee osteoarthritis [0.03%]
膝骨关节炎患者六分钟步行试验表现的影响因素分析
Sivakami Mylvaganam,Philippa Nicolson,Ian Stanaitis et al.
Sivakami Mylvaganam et al.
Objective: The 6-minute walk test (6MWT), an Osteoarthritis Research Society International (OARSI)-recommended measure of physical function in knee osteoarthritis (OA), was originally developed to assess submaximal aerobi...
Duy K Hoang,An T Truong,Linh N Luu et al.
Duy K Hoang et al.
Objective: Although patients with radiographic knee osteoarthritis (OA) have a higher areal bone mineral density (BMD) than non-OA individuals, their fracture risk was not significantly different. This study sought to def...
Emerging concepts in osteoarthritis and musculoskeletal diseases: Insights from the University of Debrecen Musculoskeletal Symposium 2025 [0.03%]
2025德布勒森大学肌骨.symposium上的新兴概念：关节炎和肌骨疾病的新见解
Patrik Kovács,Judit Vágó,Ali Mobasheri et al.
Patrik Kovács et al.
Objective: To highlight the key translational advances and interdisciplinary discussions from the 2025 University of Debrecen Musculoskeletal Symposium (UD-MUSK), focusing on osteoarthritis (OA) and related musculoskeleta...
Clinical validation of fully automated (peri-)articular tissue analysis for assessing osteoarthritis progression: A narrative review [0.03%]
全自动软骨组织分析检测骨关节炎进展的临床验证：综述文章
Wolfgang Wirth,Jana Eder
Wolfgang Wirth
Numerous studies have presented fully automated techniques for assessing structural osteoarthritis (OA) progression, with recent work increasingly relying on deep learning (DL)-based methods. The objective of this narrative review was to su...
Prevalence and impact of sleep disorders in osteoarthritis: A systematic review and meta-analysis [0.03%]
骨关节炎患者睡眠障碍的患病率和影响：系统评价和 Meta 分析
Sylvain Mathieu,Anne-Christine Rat,Jérémie Sellam
Sylvain Mathieu
Objective: Sleep disorders (SD) are increasingly recognized as a major contributor to the symptom burden of osteoarthritis (OA), yet their epidemiology and clinical impact remain insufficiently characterized. This systema...
Identification of alkaline phosphatase as a putative biomarker of anti-NGF treatment-associated arthropathies: Machine learning-assisted analyses of clinical trial data [0.03%]
碱性磷酸酶作为抗NGF治疗相关关节病潜在生物标志物的鉴定：临床试验数据的机器学习辅助分析
Matthew F Wipperman,Peter J Ehmann,Debra A G McIntyre et al.
Matthew F Wipperman et al.
Objective: Nerve growth factor (NGF) inhibitors have been shown to provide pain relief in patients with osteoarthritis but are associated with adjudicated arthropathies (AAs). Exploratory analyses were performed to identi...
Associations of clinical measures and structural knee magnetic resonance imaging findings with knee symptoms in a birth cohort of 33-year-old adults [0.03%]
临床指标和膝关节磁共振结构影像学表现与成人膝关节症状的相关性——一项横断面流行病学调查(出生于1987年的人群)
Antti Kemppainen,Joona Tapio,Miika T Nieminen et al.
Antti Kemppainen et al.
Objective: To investigate the associations between knee magnetic resonance imaging (MRI) findings, knee joint symptoms and related health factors in a random subpopulation of 33-year-olds from the Northern Finland 1986 Bi...
Acellular placental extract outcomes in post-traumatic osteoarthritis model [0.03%]
胎盘提取物在创伤性骨关节炎模型中的效果研究
Xue Ma,Marcel G Brown,Matthew S Gwilt et al.
Xue Ma et al.
Objective: Evaluate the effect of human placental extract (HPE) on healthy and osteoarthritic articular cartilage. Method: Post-traumat...
Frequency and mutual associations of knee osteoarthritis features on ultrasound imaging in recent-onset symptomatic knee osteoarthritis patients: A cross-sectional analysis in a convenience sample of Dutch patients [0.03%]
荷兰患者的便利样本中近期出现膝关节骨关节炎症状的患者超声成像特征的频率和相互关联：横断面分析
Lianne Straetemans,Joost Verbruggen,Luc J M Heijnens et al.
Lianne Straetemans et al.
Objectives: To understand the diagnostic utility of ultrasound (US) for early diagnosis of knee osteoarthritis (KOA), this study aims to assess the frequency of KOA-associated US-detectable synovitis, osteophytes, and men...
A randomized, double-blind, placebo-controlled and dose-ranging study to evaluate the safety and efficacy of XG005 in subjects with painful osteoarthritis of the knee [0.03%]
治疗膝骨关节炎疼痛的XG005随机、双盲、安慰剂对照及剂量范围研究：安全性和有效性评价
Limin Ren,Wenjie Zheng,Zhenpeng Guan et al.
Limin Ren et al.
Objective: Symptomatic treatment for osteoarthritis (OA) remains a major unmet need. This trial evaluated XG005, a novel, non-opioid, dual-mechanism agent targeting both inflammatory and neuropathic pathways in patients w...