The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis [0.03%]
体重减轻干预对老年伴或不伴骨关节炎患者的物理功能和血清生物标志物的影响
James A Coppock,Amy L McNulty,Kathryn N Porter Starr et al.
James A Coppock et al.
Objective: To examine the effects of a 6-month weight loss intervention on physical function, inflammatory biomarkers, and metabolic biomarkers in both those with and without osteoarthritis (OA). ...
Prognostic value of illness perception on changes in knee pain among elderly individuals: Two-year results from the Frederiksberg Cohort study [0.03%]
丹麦腓特烈堡队列研究中老年人群膝痛变化的预后因素——两年的研究结果
Elisabeth Ginnerup-Nielsen,Robin Christensen,Berit L Heitmann et al.
Elisabeth Ginnerup-Nielsen et al.
Objective: To investigate the prognostic value of illness perception (IP) on knee pain, quality of life (QoL) and functional level in elderly individuals reporting knee pain. ...
Association of adipokines with severity of knee osteoarthritis assessed clinically and on magnetic resonance imaging [0.03%]
脂肪细胞因子与临床和磁共振影像评估的膝骨关节炎严重程度的关系
Timothy Kit Yeong Chong,Jin-Rong Tan,Cheryl Ann Ma et al.
Timothy Kit Yeong Chong et al.
Objectives: We aimed to evaluate the association between the adipokines: Leptin, Adiponectin, Resistin, and high sensitive-C-reactive protein (hs-CRP) with clinical, radiographical and magnetic resonance imaging (MRI) ass...
Pain Informed Movement for people with knee osteoarthritis: Protocol for a pilot randomized controlled trial [0.03%]
膝关节骨关节炎患者基于疼痛指导运动的试点随机对照试验方案
Shirin Modarresi,Neil Pearson,Kim Madden et al.
Shirin Modarresi et al.
Objective: Conservative pain management strategies for knee osteoarthritis (KOA) have limited effectiveness and do not employ a pain-mechanism informed approach. Pain Informed Movement is a novel intervention combining mi...
Feasibility of pain informed movement program for people with knee osteoarthritis [0.03%]
膝骨关节炎患者疼痛知情运动项目的可行性研究
Shirin Modarresi,Neil Pearson,Kim Madden et al.
Shirin Modarresi et al.
Objective: To establish the feasibility of an intervention consisting of neuromuscular exercise, mind-body techniques, and pain neuroscience education (PNE), referred to as Pain Informed Movement in people with knee Osteo...
The effect of geographic location and payor type on provincial-wide delivery of the GLA:D program for hip and knee osteoarthritis in Alberta, Canada [0.03%]
地理位置和付费类型对加拿大艾伯塔省GLA:D骨关节炎髋膝递送的影响
C Allyson Jones,Geneviève Jessiman-Perreault,Ania Anna Kania-Richmond et al.
C Allyson Jones et al.
Objective: The Good Life with osteoArthritis: Denmark (GLA:D™) program for knee and hip osteoarthritis has been shown to be effective, but evaluations have yet to explore whether effectiveness differs by program context....
Depleting transforming growth factor beta receptor 2 signalling in the cartilage of itga1-null mice attenuates spontaneous knee osteoarthritis [0.03%]
耗竭ITGA1缺陷型小鼠软骨中转化生长因子β受体2信号可减轻自发性膝关节骨关节炎
Jennifer St Amant,Jana Michaud,Daniel Hinds et al.
Jennifer St Amant et al.
Objectives: Integrin α1β1 protects against osteoarthritis (OA) when it is upregulated in the superficial zone of cartilage in the early stages of disease. However, the mechanism behind this protection is unknown. Integr...
Efficacy of tumor necrosis factor inhibitors in hand osteoarthritis: A systematic review and meta-analysis of randomized controlled trials [0.03%]
肿瘤坏死因子抑制剂治疗手部骨关节炎的疗效：随机对照试验的系统评价和meta分析
Mahnuma Mahfuz Estee,Flavia M Cicuttini,Matthew J Page et al.
Mahnuma Mahfuz Estee et al.
Objectives: This study aimed at systematically review the evidence for the efficacy of Tumor Necrosis Factor (TNF) inhibitors on symptoms and structural outcomes in hand osteoarthritis. ...
Development and validation of a machine learning-supported strategy of patient selection for osteoarthritis clinical trials: the IMI-APPROACH study [0.03%]
机器学习支持的选择骨关节炎临床试验受试者的策略的开发和验证：IMI-APPROACH研究
Paweł Widera,Paco M J Welsing,Samuel O Danso et al.
Paweł Widera et al.
Objectives: To efficiently assess the disease-modifying potential of new osteoarthritis treatments, clinical trials need progression-enriched patient populations. To assess whether the application of machine learning resu...
Measures of sleep are not routinely captured in trials assessing treatment outcomes in knee osteoarthritis - A scoping systematic review and call to action [0.03%]
系统评价：在膝骨关节炎治疗效果的试验中未常规收集睡眠指标- 一项概述性系统综述及呼吁行动
Jessica Feda,Tyler Miller,Jodi L Young et al.
Jessica Feda et al.
Objective: To identify and map the extent to which trials for pain interventions in individuals with knee osteoarthritis (OA) track measures of sleep, characterize the type of sleep measure assessed, and assess their infl...