Prevalence and impact of sleep disorders in osteoarthritis: A systematic review and meta-analysis [0.03%]
骨关节炎患者睡眠障碍的患病率和影响：系统评价和 Meta 分析
Sylvain Mathieu,Anne-Christine Rat,Jérémie Sellam
Sylvain Mathieu
Objective: Sleep disorders (SD) are increasingly recognized as a major contributor to the symptom burden of osteoarthritis (OA), yet their epidemiology and clinical impact remain insufficiently characterized. This systema...
Identification of alkaline phosphatase as a putative biomarker of anti-NGF treatment-associated arthropathies: Machine learning-assisted analyses of clinical trial data [0.03%]
碱性磷酸酶作为抗NGF治疗相关关节病潜在生物标志物的鉴定：临床试验数据的机器学习辅助分析
Matthew F Wipperman,Peter J Ehmann,Debra A G McIntyre et al.
Matthew F Wipperman et al.
Objective: Nerve growth factor (NGF) inhibitors have been shown to provide pain relief in patients with osteoarthritis but are associated with adjudicated arthropathies (AAs). Exploratory analyses were performed to identi...
Associations of clinical measures and structural knee magnetic resonance imaging findings with knee symptoms in a birth cohort of 33-year-old adults [0.03%]
临床指标和膝关节磁共振结构影像学表现与成人膝关节症状的相关性——一项横断面流行病学调查(出生于1987年的人群)
Antti Kemppainen,Joona Tapio,Miika T Nieminen et al.
Antti Kemppainen et al.
Objective: To investigate the associations between knee magnetic resonance imaging (MRI) findings, knee joint symptoms and related health factors in a random subpopulation of 33-year-olds from the Northern Finland 1986 Bi...
Acellular placental extract outcomes in post-traumatic osteoarthritis model [0.03%]
胎盘提取物在创伤性骨关节炎模型中的效果研究
Xue Ma,Marcel G Brown,Matthew S Gwilt et al.
Xue Ma et al.
Objective: Evaluate the effect of human placental extract (HPE) on healthy and osteoarthritic articular cartilage. Method: Post-traumat...
Frequency and mutual associations of knee osteoarthritis features on ultrasound imaging in recent-onset symptomatic knee osteoarthritis patients: A cross-sectional analysis in a convenience sample of Dutch patients [0.03%]
荷兰患者的便利样本中近期出现膝关节骨关节炎症状的患者超声成像特征的频率和相互关联：横断面分析
Lianne Straetemans,Joost Verbruggen,Luc J M Heijnens et al.
Lianne Straetemans et al.
Objectives: To understand the diagnostic utility of ultrasound (US) for early diagnosis of knee osteoarthritis (KOA), this study aims to assess the frequency of KOA-associated US-detectable synovitis, osteophytes, and men...
A randomized, double-blind, placebo-controlled and dose-ranging study to evaluate the safety and efficacy of XG005 in subjects with painful osteoarthritis of the knee [0.03%]
治疗膝骨关节炎疼痛的XG005随机、双盲、安慰剂对照及剂量范围研究：安全性和有效性评价
Limin Ren,Wenjie Zheng,Zhenpeng Guan et al.
Limin Ren et al.
Objective: Symptomatic treatment for osteoarthritis (OA) remains a major unmet need. This trial evaluated XG005, a novel, non-opioid, dual-mechanism agent targeting both inflammatory and neuropathic pathways in patients w...
Baseline pain medication is associated with longer duration of high adherence in a three-month digital treatment program for hip and knee osteoarthritis [0.03%]
基线镇痛药物与髋关节和膝关节骨关节炎为期三个月的数字治疗程序中较高依从性持续时间较长相关
Leif E Dahlberg,Simon P Rowland,Jack T Pearson et al.
Leif E Dahlberg et al.
Objective: To investigate whether baseline use of pain medication is associated with program adherence during a three-month digital treatment program for individuals with hip or knee osteoarthritis (OA). ...
Magnetic resonance imaging-defined knee osteoarthritis rarely occurs without cartilage damage [0.03%]
磁共振定义的膝关节骨关节炎很少没有软骨损伤的情况下发生
Alison H Chang,Leena Sharma,Frank W Roemer et al.
Alison H Chang et al.
Objective: Magnetic resonance imaging (MRI) enables detection of early, multi-tissue changes in knee osteoarthritis (OA). A Delphi-derived MRI definition integrates findings across multiple joint tissues to classify tibio...
Two years efficacy and safety outcomes of using allogeneic, pooled mesenchymal stromal cells for osteoarthritis of knee in a double-blind randomized placebo-controlled phase 3 study [0.03%]
人脐带华通胶间充质干细胞治疗膝骨关节炎的随机、双盲、安慰剂对照Ⅲ期临床研究：为期两年的安全性和有效性分析
Pawan Kumar Gupta,Sunil Maheshwari,Joe Joseph Cherian et al.
Pawan Kumar Gupta et al.
Objective: The aim of this study was to assess whether allogeneic cultured, pooled, bone marrow derived mesenchymal stromal cells (BMMSCs), has potential to impact progression of osteoarthritis (OA). ...
The potential of unstructured "physical activity" data for understanding relationships between movement-induced joint loading and osteoarthritis progression [0.03%]
不规则的“身体活动”数据在理解运动诱发关节负荷与骨关节炎进展之间的关系方面的潜在作用
Peter Schaefer,Zoe Struk,Kerry E Costello
Peter Schaefer
Gait and exercise have been extensively studied in knee osteoarthritis (OA) as potential interventions to modify mechanical loading at the joint and, subsequently, influence biological processes and disease progression. However, this resear...