Slow acting medications for progressive and painful knee osteoarthritis. How do we assess the benefit to risk of these potentially novel therapies? [0.03%]
慢作用药物治疗进行性和疼痛性膝关节骨关节炎的风险效益比如何评估？
Nancy E Lane,Lee S Simon,Jeyanesh Tambiah
Nancy E Lane
Brain functional imaging contributions in osteoarthritis-related pain: A viewpoint [0.03%]
脑功能影像在骨关节炎相关疼痛中的贡献：一种观点
Camille Fauchon,Marie Binvignat,Francis Berenbaum et al.
Camille Fauchon et al.
Objective: Neuroimaging investigations are critical to provide a more direct assessment of brain disturbances associated with osteoarthritis (OA)-related pain, and to better understand its pathophysiology to develop new t...
Everyday living with osteoarthritis in the global South: A qualitative focus group inquiry in Nigeria [0.03%]
发展中国家的骨关节炎患者的日常生活经验——尼日利亚的定性焦点小组研究
Tolulope Owoyemi,Ibidunni Alonge,Oladapo Adetunji et al.
Tolulope Owoyemi et al.
Objective: Africa contributes significantly to the increasing global prevalence (>37 %), unmet need and treatment burden for people with osteoarthritis. Despite this, little research has examined the expressed needs of ...
The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain [0.03%]
与人类骨髓病变和疼痛相关的实验大鼠骨关节炎骨评分（Histologic Pathology）
Daniel F McWilliams,Mohsen Shahtaheri,Soraya Koushesh et al.
Daniel F McWilliams et al.
Objectives: Histological osteochondral characteristics of inflammation, fibrosis, vascularity, cartilage islands, vessels entering cartilage, thickened trabeculae and cysts are associated with bone marrow lesions (BMLs) i...
MicroRNA-181a/b-1 enhances chondroprogenitor anabolism and downregulates aquaporin-9 [0.03%]
微小核糖核酸-181a/b-1增强软骨前体细胞合成代谢并下调水通道蛋白-9表达
Austin Bell-Hensley,Victor Gustavo Balera Brito,Lei Cai et al.
Austin Bell-Hensley et al.
Objective: Effective osteoarthritis treatments that enhance the anabolic/regenerative capacity of chondrocytes are needed. Studying cartilage development processes may inform us of approaches to control chondrocyte differ...
Safety and preliminary efficacy of transcutaneous auricular vagus nerve stimulation on chronic knee pain: A pilot trial [0.03%]
耳迷走神经刺激治疗慢性膝关节痛的安全性和初步疗效：一项试点试验
Kosaku Aoyagi,Elias Rivas,Roxanna Shababi et al.
Kosaku Aoyagi et al.
Objective: Transcutaneous auricular vagus nerve stimulation (tVNS) may be an innovative treatment for symptoms of knee osteoarthritis (OA) due to possible shared pathological mechanisms between diminished parasympathetic ...
Study protocol for the PICASSO trial: A randomized placebo-controlled trial to investigate the efficacy and safety of intraarticular steroid injections and an occupational therapy intervention in painful inflammatory carpometacarpal-1 osteoarthritis [0.03%]
PICASSO试验研究方案：一项随机双盲安慰剂对照试验，调查腕掌第一关节炎性疼痛性骨关节炎患者的糖皮质激素注射和作业疗法的有效性和安全性
Marthe Gløersen,Ingvild Kjeken,A T Tveter et al.
Marthe Gløersen et al.
Objective: Our primary objectives are to assess whether intraarticular corticosteroid injections are superior to saline injections with regards to thumb base pain after 4 weeks, and to compare the efficacy of steroid inje...
A scoping review of statistical methods to investigate colocalization between genetic associations and microRNA expression in osteoarthritis [0.03%]
一种统计方法的综述：调查遗传关联和微小核糖核酸表达在骨关节炎中的同定位
Kathleen Zang,Myriam Brossard,Thomas Wilson et al.
Kathleen Zang et al.
Background: Genetic colocalization analysis is a statistical method that evaluates whether two traits (e.g., osteoarthritis [OA] risk and microRNA [miRNA] expression levels) share the same or distinct genetic association ...
Risk of all-cause mortality in patients with knee osteoarthritis: A systematic review and meta-analysis of cohort studies [0.03%]
膝骨关节炎患者全因死亡率的系统评价和meta分析
Pei-En Kao,Amy Ker
Pei-En Kao
Objective: This systematic review and meta-analysis aimed to evaluate the risk of all-cause mortality in patients with knee osteoarthritis (OA). Design: ...
Proteomic analysis reveals biomarkers associated with performance-based joint function and patient-reported outcomes in knee osteoarthritis [0.03%]
基于蛋白质组学分析发现膝关节骨关节炎患者功能表现及自我报告结果相关的生物标志物
Josefine E Naili,Aisha S Ahmed,Margareta Hedström et al.
Josefine E Naili et al.
Objective: This study aimed to identify proteins associated with clinical manifestations of knee osteoarthritis (KOA), including performance-based joint function and patient-reported outcome measures (PROM). ...