High glucose upregulates BMAL1 in chondrocytes from macroscopically normal and osteoarthritic human cartilage but this only results in increased collagen synthesis in chondrocytes from macroscopically normal cartilage regions [0.03%]
高糖上调正常外观和骨关节炎人软骨中基质细胞核蛋白1（BMAL1）但仅在正常外观软骨区域的软骨细胞中增加胶原合成
Lekha Jain,Jacob T Munro,Jade Tamatea et al.
Lekha Jain et al.
Objective: Osteoarthritic (OA) chondrocytes exhibit limited capacity for new collagen synthesis. High glucose promotes collagen I and III production by fibroblasts. The purpose of this study was to determine if it also pr...
The role of metabolic syndrome in osteoarthritis development: Is obesity the key driver? [0.03%]
代谢综合征在骨关节炎发病中的作用：肥胖是关键驱动因素吗？
Dell&#x;Isola Andrea,Magnusson Karin,Vinblad Johanna et al.
Dell&#x;Isola Andrea et al.
Objective: Investigate the role of metabolic syndrome and obesity in incident osteoarthritis (OA). Methods: Prospective cohort study wi...
Tolerability of high intensity interval training (HIIT) in individuals living with knee OA and at risk for cardiovascular disease: A prospective cohort study (THIPO) [0.03%]
高膝骨关节炎伴心血管疾病风险个体进行高强度间歇训练(HIIT)的耐受性：前瞻性队列研究(THIPO)
Mathilde Espe Pedersen,Thomas Bandholm,Mathias Ried-Larsen et al.
Mathilde Espe Pedersen et al.
Objective: To explore the tolerability of a 12-week High Intensity Interval Training (HIIT) program in individuals with knee osteoarthritis (OA) at elevated risk for cardiovascular disease (CVD). ...
Studying the formation of the zone of calcified cartilage in bovine cartilage explants ex vivo [0.03%]
体外研究牛软骨移植物中钙化软骨区的形成
Jietao Xu,Andrea Schwab,Elias Salzer et al.
Jietao Xu et al.
Objective: The zone of calcified cartilage (ZCC) connects non-calcified articular cartilage to the subchondral bone, acting as transitional layer. Regeneration of this layer is key for cartilage repair but remains a chall...
Association between symptomatic knee osteoarthritis and health-related quality of life in individuals with type 2 diabetes: A cross-sectional study [0.03%]
II型糖尿病患者膝骨关节炎与健康相关生活质量的关系：横断面研究
Abdalmohsen Almodahka,Alanna Weisman,Baiju R Shah et al.
Abdalmohsen Almodahka et al.
Objective: Knee osteoarthritis (OA) and type 2 diabetes (T2D) commonly coexist, but their combined impact on health-related quality of life (HRQoL) remains understudied. We assessed the association between symptomatic kne...
Clinical characteristics and physical activity levels of patients with knee osteoarthritis with and without a previous knee injury: A cross-sectional study [0.03%]
有无膝关节既往损伤的膝骨关节炎患者的临床特征和身体活动水平：横断面研究
Richard E Magony,Jeffrey S Brooks,Jenna M Schulz et al.
Richard E Magony et al.
Objective: To compare clinical characteristics and physical activity levels of patients with mild-to-moderate knee osteoarthritis (OA). Methods: ...
Determinants of six-minute walk test performance in individuals with knee osteoarthritis [0.03%]
膝骨关节炎患者六分钟步行试验表现的影响因素分析
Sivakami Mylvaganam,Philippa Nicolson,Ian Stanaitis et al.
Sivakami Mylvaganam et al.
Objective: The 6-minute walk test (6MWT), an Osteoarthritis Research Society International (OARSI)-recommended measure of physical function in knee osteoarthritis (OA), was originally developed to assess submaximal aerobi...
Duy K Hoang,An T Truong,Linh N Luu et al.
Duy K Hoang et al.
Objective: Although patients with radiographic knee osteoarthritis (OA) have a higher areal bone mineral density (BMD) than non-OA individuals, their fracture risk was not significantly different. This study sought to def...
Emerging concepts in osteoarthritis and musculoskeletal diseases: Insights from the University of Debrecen Musculoskeletal Symposium 2025 [0.03%]
2025德布勒森大学肌骨.symposium上的新兴概念：关节炎和肌骨疾病的新见解
Patrik Kovács,Judit Vágó,Ali Mobasheri et al.
Patrik Kovács et al.
Objective: To highlight the key translational advances and interdisciplinary discussions from the 2025 University of Debrecen Musculoskeletal Symposium (UD-MUSK), focusing on osteoarthritis (OA) and related musculoskeleta...
Clinical validation of fully automated (peri-)articular tissue analysis for assessing osteoarthritis progression: A narrative review [0.03%]
全自动软骨组织分析检测骨关节炎进展的临床验证：综述文章
Wolfgang Wirth,Jana Eder
Wolfgang Wirth
Numerous studies have presented fully automated techniques for assessing structural osteoarthritis (OA) progression, with recent work increasingly relying on deep learning (DL)-based methods. The objective of this narrative review was to su...