Hydroxycitric acid reconstructs damaged articular cartilages by modifying the metabolic cascade in chondrogenic cells [0.03%]
羟基柠檬酸通过修饰软骨细胞代谢途径修复受损的关节软骨
Yoshiyuki Mizushina,Liping Sun,Megumi Nishio et al.
Yoshiyuki Mizushina et al.
Objective: Osteoarthritis, a degenerative joint disease, requires innovative therapies due to the limited ability of cartilage to regenerate. Since mesenchymal stem cells (MSCs) provide a cell source for chondrogenic cell...
Intra-articular injection of inorganic pyrophosphate improves IL-1β-induced cartilage damage in rat model of knee osteoarthritis in vivo [0.03%]
体内玻璃酸钠联合无机焦磷酸盐关节腔注射对膝骨关节炎软骨的保护作用及机制研究
Émilie Velot,Mathilde Guibert,Meriem Koufany et al.
Émilie Velot et al.
Objective: Osteoarthritis (OA) is the most common form of chronic joint disease, affecting mainly the elderly population. This disorder is caused by cartilage degeneration with complex changes in the chondrocyte phenotype...
Inter-assay variability in the measurement of urinary C-terminal cross-linked telopeptide of type II collagen following anterior cruciate ligament reconstruction [0.03%]
前交叉韧带重建术后尿液II型胶原C端交联肽检测的跨试验变异性
Lachlan M Batty,Kate E Webster,Natasha Vassileff et al.
Lachlan M Batty et al.
Objective: To compare urinary C-terminal cross-linked telopeptide of type II collagen (u-CTX-II) concentrations and trends as measured by two different commercially available enzyme-linked immunosorbent assays (ELISA) in ...
Metformin for low back pain: Study protocol for a randomised, double-blind, placebo-controlled trial [0.03%]
二甲双胍治疗慢性下腰痛的临床研究方案
Yuan Z Lim,Donna M Urquhart,Yuanyuan Wang et al.
Yuan Z Lim et al.
Background: Chronic low back pain is a major cause of pain and disability with limited effective therapies. Metformin is a safe, inexpensive, well-tolerated drug that has pleotropic effects, including effects on pain path...
Frontal plane mechanical leg alignment estimation from knee x-rays using deep learning [0.03%]
基于膝关节X射线的深度学习 frontal平面下肢力线估计
Kenneth Chen,Christoph Stotter,Christopher Lepenik et al.
Kenneth Chen et al.
Objective: Lower limb malalignment can complicate symptoms and accelerate knee osteoarthritis (OA), necessitating consideration in study population selection. In this study, we develop and validate a deep learning model t...
Postnatal deletion of Phlpp1 in chondrocytes delays post-traumatic osteoarthritis in male mice [0.03%]
产后在软骨细胞中删除Phlpp1可延缓雄性小鼠的创伤后骨关节炎的发展
Samantha R Weaver,Katherine M Arnold,Eduardo Peralta-Herrera et al.
Samantha R Weaver et al.
Objective: Osteoarthritis is a chronic, debilitating disease that causes long-term pain and immobility. Germline deletion of Phlpp1 or administration of small molecules that inhibit Phlpp1 prevents post-traumatic osteoart...
Protocol for the MERINO study: A randomized placebo-controlled trial assessing the efficacy, safety, and cost-effectiveness of methotrexate in people with erosive hand osteoarthritis [0.03%]
MERINO研究方案：甲氨蝶呤治疗侵蚀性手骨关节炎患者有效性和安全性的一项随机、双盲、安慰剂对照试验及成本效益分析
Alexander Mathiessen,Line Gaundal,Joseph Sexton et al.
Alexander Mathiessen et al.
Objective: Previous studies on the efficacy of methotrexate in people with hand osteoarthritis (OA) have shown conflicting results. The MERINO trial aims to investigate the efficacy and safety of methotrexate in people wi...
Knee joint extension limitation in female patients with knee osteoarthritis affects the infrapatellar fat pad hardness and hemoglobin concentration by isometric quadriceps exercise [0.03%]
女性膝骨关节炎患者膝关节伸展受限影响半膜脂肪垫的硬度和血红蛋白浓度的等长股四头肌练习
Syoya Nakanishi,Masahiro Tsutsumi,Takashi Kitagawa et al.
Syoya Nakanishi et al.
Objective: To investigate whether there is a difference in hardness and hemoglobin concentration changes in the infrapatellar fat pad (IFP) during isometric quadriceps exercise (IQE) in patients with knee osteoarthritis (...
Association between the immune-inflammation indicators and osteoarthritis - NHANES 1999-2018 [0.03%]
免疫炎症指标与骨关节炎的关系——基于NHANES1999-2018年调查数据的横断面研究
Yan Xue,Cheng Chang,Yajun Chen et al.
Yan Xue et al.
Background: Investigate the link between systemic immune-inflammatory index (SII) and Systemic Immune Response Index (SIRI) with osteoarthritis (OA) using National Health and Nutrition Examination Survey (NHANES) data (19...
Tibiofemoral cartilage strain and recovery following a 3-mile run measured using deep learning segmentation of bone and cartilage [0.03%]
基于深度学习的骨和软骨分割技术评估长跑后膝关节软骨应力及恢复状况
Patrick X Bradley,Sophia Y Kim-Wang,Brooke S Blaisdell et al.
Patrick X Bradley et al.
Objective: We sought to measure the deformation of tibiofemoral cartilage immediately following a 3-mile treadmill run, as well as the recovery of cartilage thickness the following day. To enable these measurements, we de...