Osteoarthritis as an evolutionary legacy: Biological ageing and chondrocyte hypertrophy [0.03%]
骨关节炎作为进化遗留问题：生物衰老与软骨细胞肥大
Peter M van der Kraan
Peter M van der Kraan
Objective: Osteoarthritis (OA) is a progressive joint disease habitually linked to ageing, characterized by the gradual breakdown of cartilage leading to pain and reduced mobility. Historically viewed as mainly a "wear an...
Mature and inactive microvessels are prominent in areolar synovium of femoroacetabular impingement and hip osteoarthritis patients [0.03%]
股骨髋臼撞击症和髋关节骨关节炎患者的脂肪垫滑膜中成熟且不活跃的微血管较多见
Ronan J Anderson,Brent A Lanting,C Thomas Appleton et al.
Ronan J Anderson et al.
Objective: To provide insight into the earliest changes in hip osteoarthritis (OA) pathogenesis. Histopathology of synovium was investigated in patients with femoroacetabular impingement (FAI), FAI with early hip osteoart...
From mechanism to medicine: The progress and potential of epigenetics in osteoarthritis [0.03%]
从机制到药物：骨关节炎表观遗传学的研究进展与潜力
Jack B Roberts,Jason S Rockel,Rick Mulders et al.
Jack B Roberts et al.
Objective: Osteoarthritis (OA) is a chronic, degenerative disease of the articular joints. The disease presents an enormous clinical and economic burden globally, due in part to the lack of disease modifying therapies. Fo...
Potential sources of pain in symptomatic degenerative meniscal tear: A narrative review [0.03%]
有症状的退变性半月板撕裂的潜在疼痛来源：综述型研究
Love Tsai,Elizabeth Matzkin,Morgan H Jones et al.
Love Tsai et al.
Importance: Although degenerative meniscal tear is relatively prevalent in older persons, the sources of the accompanying pain and mechanical symptoms-such as knee clicking, locking, and popping-are unclear, making target...
Measurement of expectations regarding exercise therapy of patients with hip and knee osteoarthritis: A scoping review [0.03%]
测量髋膝关节骨关节炎患者的物理治疗预期：系统评价
A P M Konings-Pijnappels,M C van der Steen,H Seetsen-van Schelven et al.
A P M Konings-Pijnappels et al.
Objective: While exercise therapy generally yields positive outcomes in patients with hip or knee osteoarthritis (HOA or KOA), individual results vary. Expectations may influence treatment results, but research on this to...
Fibrocartilage repair involves chronic cellular senescence in a rat model of bone marrow stimulation [0.03%]
骨髓刺激大鼠模型软骨修复过程中慢性细胞衰老的作用
Luke Childress,Landon B Gatrell,Hong Wu et al.
Luke Childress et al.
Objective: Cellular senescence has been implicated in the progression of post-traumatic osteoarthritis, but any role in pre-osteoarthritic cartilage repair is unknown. Our objective was to determine whether senescent cell...
The current and changing role of glucagon-like peptide-1 receptor agonists in knee osteoarthritis [0.03%]
胰高血糖素样肽-1受体激动剂在膝骨关节炎中作用的现状及变化趋势
Anne D Holleman,Jeffrey N Katz
Anne D Holleman
Inflammatory mechanisms underlying metabolic syndrome-associated and potential treatments [0.03%]
代谢综合征相关的炎症机制及潜在治疗措施
Shiqian Huang,Jiawei Chen,Hao Zhang et al.
Shiqian Huang et al.
Objectives: Osteoarthritis (OA), a debilitating disease, has been recognized as a heterogenous disease, with metabolic syndrome-associated osteoarthritis (MetS-OA) emerging as a significant area of interest. Currently, th...
Effects of high impact exercise on systemic cytokines in women with mild knee osteoarthritis: A 12-month RCT [0.03%]
高强度冲击运动对轻度膝骨关节炎女性全身细胞因子的影响：一项为期12个月的随机对照试验
Ville-Markus Konola,Juhani Multanen,Johanna K Ihalainen et al.
Ville-Markus Konola et al.
Objective: This study investigated the effects of a high-impact exercise regimen compared with a reference group on systemic cytokine levels in patients with mild knee osteoarthritis (OA). Furthermore, associations betwee...
Stromal cell-based injection therapies for the treatment of knee osteoarthritis: A systematic review of level I randomized controlled trials [0.03%]
基于间质细胞的注射疗法治疗膝关节骨关节炎：1级随机对照试验系统评价
Jaydeep Dhillon,James A Maguire,Matthew J Kraeutler
Jaydeep Dhillon
Objective: To systematically review randomized controlled trials (RCTs) to compare clinical outcomes of stromal cell-based injection therapies versus other non-operative treatment modalities for the treatment of knee oste...