The interplay of mutagenesis and extracellular DNA: a new chapter in urothelial cancer research [0.03%]
DNA突变与细胞外DNA之间的相互作用：泌尿上皮癌研究新篇章
Xuan Zhang,Yirong Li,Xinghua Long
Xuan Zhang
Combined inhibition of protein kinase B and enhancer of zeste homolog 2: a novel strategy to induce triple-negative breast cancer cell death [0.03%]
蛋白激酶B和同源框增强子-of-zeste联合抑制：诱导三阴性乳腺癌细胞凋亡的新策略
Xinxiao ZhuProtein,Yongqiang Wang,Long Zhang
Xinxiao ZhuProtein
Tear lactate improves the evaluation of proliferative diabetic retinopathy in type-2 diabetes patients [0.03%]
Ⅱ型糖尿病患者中撕裂乳酸改善增殖性糖尿病视网膜病变的评估效果
Xin Wen,Tsz Kin Ng,Guihua Zhang et al.
Xin Wen et al.
Proliferative diabetic retinopathy (PDR) is the advanced stage of DR and characterized by retinal neovascularization (RNV). The diagnosis of PDR relies primarily on imaging features and blood glucose levels. Whether early biomarkers in othe...
Liquid biopsy using plasma proteomics in predicting efficacy and tolerance of PD-1/PD-L1 blockades in NSCLC: a prospective exploratory study [0.03%]
基于血浆蛋白质组学的液体活检在预测NSCLC患者PD-1/PD-L1抑制剂疗效和毒副反应中的应用价值：一项前瞻性探索性研究
Yuan Gao,Fei Qi,Wenhao Zhou et al.
Yuan Gao et al.
Immune checkpoint inhibitors (ICIs) show limited efficacy in non-small cell lung cancer (NSCLC), highlighting the need for predictive biomarkers. Here we prospectively analysed serial plasma samples from 34 ICI-treated advanced NSCLC patien...
Hyaluronidase: structure, mechanism of action, diseases and therapeutic targets [0.03%]
透明质酸酶：结构、作用机制、疾病及治疗靶点
Jiamin Lu,Zheng Zhao,Lingli Pan et al.
Jiamin Lu et al.
Hyaluronidase (HAase), a family of enzymes critical for regulating physiological and pathological states, catalyzes the degradation of hyaluronic acid (HA), a key component of the extracellular matrix (ECM). By modulating ECM composition an...
LncRNA small nucleolar RNA host gene 1 (SNHG1) mediates acidic bile salt-induced EMT via the ULK1-Notch1 axis in Barrett's esophagus [0.03%]
长链非编码RNA小核仁RNA宿主基因1(SNHG1)通过ULK1-Notch1轴介导酸性胆盐诱导的Barrett食管上皮间质转化(EMT)
Jianfeng Zhou,Rongyan Zhao,Zixiang Li et al.
Jianfeng Zhou et al.
Barrett's esophagus (BE) is a precancerous condition closely linked to chronic gastroesophageal reflux disease, characterized by the abnormal transformation of esophageal squamous mucosa into specialized intestinal-type epithelium, signific...
Homeobox protein B6 and homeobox protein B8 control immune-cancer cell interactions in pancreatic cancer [0.03%]
家盒蛋白B6和B8通过调控胰腺癌免疫细胞与癌细胞的相互作用促进肿瘤进展
Ludivine Bertonnier-Brouty,Sara Bsharat,Kavya Achanta et al.
Ludivine Bertonnier-Brouty et al.
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer lacking effective drugs and therefore new treatment targets are needed. In this study, we define the role of homeobox protein B6 (HOXB6) and HOXB8 in controlling pancreatic cancer t...
Emerging role of N-acetyltransferase 10 in diseases: RNA ac4C modification and beyond [0.03%]
乙酰转移酶NAT10在疾病中的新兴作用：RNA的ac4C修饰及其他功能
Lin Jiao,Yanjun Si,Yushan Yuan et al.
Lin Jiao et al.
N4-acetylcytidine (ac4C), a conserved RNA modification, plays critical roles in RNA stability and translation. As the primary enzyme catalyzing ac4C, N-acetyltransferase 10 (NAT10) is increasingly implicated in diverse diseases. This review...
Wan-Li Wang,Yi-Hang Hao,Xin Pang et al.
Wan-Li Wang et al.
Cancer pain, a highly prevalent and distressing symptom among cancer patients, has a seriously harmful effect on their life and presents a complex challenge in clinical management. Despite extensive research efforts and the existence of cli...