A dual role for miR-210-3p in hypoxia-driven signaling and mitotic regulation in cancer [0.03%]
miR-210-3p在缺氧驱动的信号传导和癌症有丝分裂调节中的双重作用
Jaime San-Juan-Guardado,María Turienzo-Durán,Álvaro Suárez-Priede et al.
Jaime San-Juan-Guardado et al.
miR-210-3p is a well-established hypoxia-induced microRNA that is commonly upregulated in a wide range of solid tumors, traditionally linked to mitochondrial repression and hypoxia-inducible factor (HIF) signaling. However, its functional r...
Activating Cannabinoid receptor 2 alleviates iron overload-induced liver damage via dual modulation of STAT3/hepcidin and Nrf2/FPN1 pathways [0.03%]
大麻素受体2活化通过STAT3/铁调素和Nrf2/铁调节蛋白1信号通路的双向调控缓解铁过载所致肝损伤
Han Deng,Yuqian Ren,Yunjie Sui et al.
Han Deng et al.
Iron overload-related liver injury is a major clinical problem in hereditary hemochromatosis, transfusional siderosis, and chronic liver diseases, yet current treatments such as iron chelation therapy and phlebotomy are limited by safety an...
Distinct immunometabolic signatures in peripheral blood mononuclear cells are linked to systemic inflammation in type 2 diabetes and diabetic kidney disease [0.03%]
2型糖尿病和糖尿病肾病外周血单个核细胞中不同的免疫代谢标志与全身性炎症有关
Clara Luna-Marco,José F Català-Senent,Julia Cacace et al.
Clara Luna-Marco et al.
Diabetic kidney disease (DKD) is a frequent complication of type 2 diabetes and is closely linked to systemic inflammation. Peripheral blood mononuclear cells (PBMCs) are markers of systemic inflammatory and metabolic stress. It is unknown ...
Succinic acid inhibits hepatocyte regenerative signaling via STAT3 SH2-domain engagement [0.03%]
富马酸通过STAT3的SH2结构域结合抑制肝细胞再生信号转导
Yiyuan Chen,Nan Xu,Hao Chen et al.
Yiyuan Chen et al.
The restoration of liver mass after partial hepatectomy (PH) and split liver transplantation (SLT) relies on efficient liver regeneration, a process highly susceptible to metabolic dysregulation. Although remodeling of the tricarboxylic aci...
Development and validation of a two-gene urine DNA methylation assay for noninvasive prostate cancer detection: a prospective multicenter study [0.03%]
前列腺癌非侵入性检测的尿DNA甲基化检测试验的研发及验证：一项前瞻性的多中心研究
Dingwen Liu,Lian Tang,Wei Xiong et al.
Dingwen Liu et al.
Prostate-specific antigen (PSA) screening lacks specificity, particularly within the 4-10 ng/mL diagnostic gray zone, leading to unnecessary prostate biopsies and overtreatment. Here, we developed and validated a streamlined urine DNA methy...
Multicenter Study
Molecular biomedicine. 2026 Aug 7;7(1):131. DOI:10.1186/s43556-026-00528-y 2026
The Acute Respiratory Distress Syndrome (ARDS): epidemiology, etiology, molecular mechanisms, diagnosis and therapeutic strategies [0.03%]
急性呼吸窘迫综合征(ARDs)的流行病学、病因、分子机制、诊断和治疗策略
Defei Tan,Junlan Zhou,Lingling Li et al.
Defei Tan et al.
Acute respiratory distress syndrome (ARDS) is a severe clinical condition characterized by acute hypoxemic respiratory failure (AHRF) and diffuse pulmonary inflammation, which can be triggered by diverse intrapulmonary, extrapulmonary, and ...
Matrix Gla Protein is a novel regulator of TGFβ-dependent fibroblast activation and kidney fibrosis [0.03%]
基质GLA蛋白是TGFβ依赖性成纤维细胞活化和肾纤维化的新调节因子
Jonatan Barrera-Chimal,Jocelyn López-Ramírez,Nathalie Henley et al.
Jonatan Barrera-Chimal et al.
Kidney fibrosis is the pathologic hallmark of chronic kidney disease (CKD) and is driven by fibroblast-to-myofibroblast transformation (FMT), excessive extracellular matrix accumulation, and persistent activation of transforming growth fact...
Immune response to DNA and RNA: structural insights, molecular mechanisms, and therapeutic targeting [0.03%]
DNA和RNA的免疫反应：结构见解、分子机制及治疗靶向
Lintao Xia,Yixi Wang,Xiuli Yan et al.
Lintao Xia et al.
The recognition of mislocalized DNA and RNA by cGAS-STING, RIG-I/MDA5, the OAS-RNase L axis, and endosomal TLR3/7/8 has emerged as a unifying paradigm linking cancer, autoinflammation, and antiviral immunity. Counterbalancing these sensors ...
Lactobacillus plantarum-derived indole-3-lactic acid inhibits prostate cancer progression through ASF1B/ENO1 axis and remodels the tumor microenvironment to enhance anti-PD-1 therapy [0.03%]
植物乳杆菌衍生的吲哚-3-乳酸通过ASF1B/ENO1轴抑制前列腺癌进展并重塑肿瘤微环境以增强抗PD-1治疗
Zhengshi Wang,Chengyou Jia,Yongqiang Liu et al.
Zhengshi Wang et al.
Prostate cancer (PCa) is one of the most common cancers in males, and its treatment remains challenging due to the tumor microenvironment (TME) with immunosuppressive properties and limited response to anti-PD-1 therapy. Gut microbiota-deri...
Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis [0.03%]
脱泛素酶USP7通过TSC1/mTOR信号轴稳定组蛋白去甲基化酶KDM5B促进肾纤维化的进程
Shiqi Lv,Ziyan Shen,Yulu Gu et al.
Shiqi Lv et al.
Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays critical regulatory roles in multiple signaling pathways by preventing the ubiquitin-mediated degradation of its substrates. Dysregulated expression of USP7 is implicated i...