Meng Lan,Huiping Ding,Yu Cao et al.
Meng Lan et al.
Aging is a complex biological process characterized by progressive functional decline at molecular, cellular, and systemic levels, accompanied by increased susceptibility to chronic diseases. Accumulating evidence indicates that the gut mic...
Prostatic fibroblast reprogramming by Interleukin-30 activates prostate cancer metastasis programs [0.03%]
白细胞介素30通过重编程前列腺纤维母细胞促进前列腺癌转移 программы
Stefania Livia Ciummo,Carlo Sorrentino,Simona Marchetti et al.
Stefania Livia Ciummo et al.
Prostate cancer (PC) progression and mortality are largely driven by therapeutic resistance, increasingly linked to dynamic tumor-stroma interactions. However, the molecular basis of cancer-fibroblast crosstalk remains incompletely understo...
MET-mediated phosphorylation of YANK2 at Y282 inhibits NEDD4L-dependent SUMOylation and degradation, promoting chemoresistance in glioblastoma [0.03%]
MET介导的YANK2在酪氨酸282处的磷酸化通过抑制NEDD4L依赖性SUMO化和降解来促进胶质母细胞瘤的化学抗性
Yue Shi,Yue Cheng,Wensheng Li et al.
Yue Shi et al.
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults, characterized by rapid progression and exceptionally poor prognosis. Identifying novel molecular drivers and therapeutic targets is urgently neede...
Death-associated protein kinase 2 (DAPK2) propagates endoplasmic reticulum stress in macrophages to worsen sepsis through HSPA5-IRE1α axis [0.03%]
死亡相关蛋白激酶2(DAPK2)通过HSPA5-IRE1α轴在巨噬细胞中传播内质网应激以加重脓毒症
Yin Ni,Guo-Zhen Tang,Chen Qiu et al.
Yin Ni et al.
Sepsis is associated with a pronounced but poorly understood endoplasmic reticulum stress (ERS) response. In this study, we found that death-associated protein kinase 2 (DAPK2), a calcium/calmodulin-regulated serine/threonine kinase, exhibi...
SEMA6A inhibits tumor progression and boosts anti-tumor immunity via blocking the ISG15/TGFβ axis in colorectal cancer [0.03%]
SEMA6A通过抑制ISG15/TGFβ轴来抑制结直肠癌进展和增强抗肿瘤免疫能力
Fang Zhang,Rixin Zhang,Zheng Yan et al.
Fang Zhang et al.
Semaphorins (SEMAs) comprise a diverse family of membrane-associated proteins whose dysregulation is implicated in various cancers, influencing tumor progression and immune responses. However, the role of SEMAs in colorectal cancer (CRC) re...
B7 homolog 3-targeted CAR-T cells secreting EGFR T-cell engagers for improved control of glioblastoma progression [0.03%]
靶向B7同源物3的CAR-T细胞分泌EGFR T细胞衔接器可有效控制胶质母细胞瘤进展
Zongliang Zhang,Nian Yang,Hui Zeng et al.
Zongliang Zhang et al.
Glioblastoma (GBM) is the most aggressive primary malignant brain tumor, and while chimeric antigen receptor-T (CAR-T) cell therapy has shown promise, its efficacy remains limited by antigen heterogeneity and immune escape. Here, we investi...
Zebrafish dspb-/- mutant as a model for non-dilated left ventricular cardiomyopathy: exploring cardiac dysfunction and exercise modulation [0.03%]
斑马鱼dspb基因敲除突变体作为非扩张型左心室心肌病模型：探索心脏功能障碍和运动调节
Serena Munteanu,Jesús Wagih Gómez,Ángel Júdez Serrano et al.
Serena Munteanu et al.
Truncating variants in the DSP gene are associated with non-dilated left ventricular cardiomyopathy (ND-LVC), characterized by impaired ventricular function without dilation. The influence of physical activity in disease onset, severity, an...
Loss of the ER-cargo protein CLN8 increases severity of acute pancreatitis and upregulates ER-stress and ER-phagy [0.03%]
ER-cargo蛋白CLN8的丢失会加重急性胰腺炎并上调ER应激和ER自噬
Lukas Zierke,Marcel Gischke,Matthias Sendler et al.
Lukas Zierke et al.
Acute pancreatitis is caused by a premature activation of digestive proteases. One hypothesis is based on the proteolytic activation of the serine protease trypsinogen by the lysosomal enzyme cathepsin B (CTSB) after co-localization in the ...
Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets [0.03%]
神经障碍中的糖淋巴系统损伤：潜在机制与治疗靶点
Nan-Nan Wang,Zhi-Jun Liu,Yong Wang et al.
Nan-Nan Wang et al.
The glymphatic system is a brain-wide metabolic clearance pathway, orchestrating the removal of neurotoxic wastes via glial-dependent perivascular networks. Mediated by polarized aquaporin-4 (AQP4) channels on astrocytic end-feet, this macr...
TELO2-interacting protein 1 (TTI1), a novel Wnt/β-catenin target gene, decreases chemo-sensitivity in colorectal cancer by modulating DNA damage responses [0.03%]
TELO2互作蛋白1(TTI1)是一种新的Wnt/β-catenin靶基因，通过调节DNA损伤应答降低结直肠癌的化疗敏感性
Yuqiao Chen,Zheng Chen,Ya Wang et al.
Yuqiao Chen et al.
Colorectal cancer is frequently driven by hyperactivation of Wnt/β-catenin signaling, which also contributes to reduced responsiveness to chemotherapy. However, how aberrant Wnt/β-catenin signaling enables colorectal cancer cells to toler...