Decoding the role of mesothelin in tumor dynamics and targeted treatment innovations [0.03%]
_mesothelin在肿瘤动力学和靶向治疗创新中的作用解析
Roberto Silvestri,Emanuela Colucci,Margherita Piccardi et al.
Roberto Silvestri et al.
Mesothelin (MSLN) is among the most studied cancer-related antigens, and it is extensively studied as a therapeutic target for the treatment of various malignancies, including pleural mesothelioma, pancreatic ductal adenocarcinoma, and ovar...
Epigenetic drugs in cancer therapy: mechanisms, immune modulation, and therapeutic applications [0.03%]
表观遗传药物在癌症治疗中的应用：机制、免疫调节和治疗作用
Chen Ma,Junkai Cheng,Jian Gu et al.
Chen Ma et al.
Epigenetic regulation is a fundamental mechanism controlling gene expression and cellular function, primarily mediated through reversible modifications such as DNA methylation, histone acetylation, and chromatin remodeling. Dysregulation of...
Asif Shahzad,Yueli Ni,Yinfeng Yang et al.
Asif Shahzad et al.
Neutrophil extracellular traps (NETs) are web-like structures composed of DNA, histones, and antimicrobial proteins that extend the defensive repertoire of neutrophils beyond classical phagocytosis and degranulation. Initially considered so...
Down-regulation of RBM47 due to diminished activation by forkhead box A1 (FOXA1) and silencing by CpG methylation is associated with epithelial-mesenchymal transition and metastasis of colorectal cancer [0.03%]
FOXA1转录激活下调和CpG甲基化沉默导致的RNA结合蛋白RBM47表达降低与结直肠癌上皮间质转化及转移相关
Matjaz Rokavec,Yuyun Du,Heiko Hermeking
Matjaz Rokavec
The gene encoding the RNA-binding motif protein 47 (RBM47) is highly expressed in epithelial cells and its down-regulation is characteristic for many types of cancer, among them colorectal cancer (CRC). However, the underlying mechanisms fo...
Cholesterol induced-mitochondrial calcium dysregulation facilitates atherosclerosis by promoting lipid accumulation in vascular smooth muscle cells [0.03%]
胆固醇诱导的线粒体钙离子失调通过促进血管平滑肌细胞脂质蓄积而促进动脉粥样硬化形成
Zhiwang Zhang,Fan Yang,Wei Wang et al.
Zhiwang Zhang et al.
Mitochondria play an essential role in regulating various physiological functions including bioenergetics, calcium homeostasis, redox signaling, and lipid metabolism and also are involved in the pathogenesis of cardiovascular diseases. Howe...
Delta-like ligand 4 mediated myeloid-derived suppressor cell metabolic reprogramming promotes neoadjuvant therapy resistance in titin-inactivated triple-negative breast cancer [0.03%]
DL4介导的髓系衍生抑制细胞代谢重编程促进titin失活型三阴性乳腺癌的新辅助治疗耐药性
Yanfang Yang,Ziyun Liu,Parhat Kaysar et al.
Yanfang Yang et al.
Triple-negative breast cancer (TNBC) is characterized by complex genomic background and treatment resistance. We first defined "Titin (TTN) inactivation", a state of TTN expression deficiency or mutation, affecting tumor progression. Howeve...
Identification of PIWI-interacting RNAs based models for lung adenocarcinoma early detection: a multicenter cohort study [0.03%]
基于PIWI相互作用RNA模型的肺腺癌早期检测多中心队列研究
Shuang Liang,Qian Hong,Qingxia Xu et al.
Shuang Liang et al.
Early detection of lung adenocarcinoma (LUAD) remains a major clinical challenge despite the widespread application of low-dose computed tomography (LDCT). Circulating PIWI-interacting RNAs (piRNAs), characterized by tumor-specific expressi...
Multicenter Study
Molecular biomedicine. 2025 Nov 30;6(1):127. DOI:10.1186/s43556-025-00368-2 2025
Fibroblasts promote the progression of benign prostatic hyperplasia through colony-stimulating factor 1 receptor-mediated RTK signaling in prostatic epithelial cells [0.03%]
成纤维细胞通过CSF1受体介导的旁分泌信号促进前列腺上皮细胞RTK信号异常激活，进而诱导BPH进展
Ming Zhan,Ruifeng Yang,Yue Gu et al.
Ming Zhan et al.
Benign prostatic hyperplasia (BPH) is a prevalent condition characterized by nonmalignant proliferation of epithelial and stromal components in the prostate, frequently resulting in lower urinary tract symptoms in aging men. While receptor ...
Sentrin-specific protease 3 (SENP3)-mediated Krüppel-like factor 4 (KLF4) deSUMOylation regulates vascular smooth muscle cell phenotypic switching in atherosclerosis [0.03%]
泛素特异性蛋白酶3介导的Krüppel样因子4去SUMO化调节动脉粥样硬化血管平滑肌细胞表型转换
Zi Wang,Yinan Wang,Ruosen Yuan et al.
Zi Wang et al.
Phenotypic switching of vascular smooth muscle cells (VSMCs) from a contractile toward a synthetic phenotype plays a critical role in atherosclerosis. Although the redox-sensitive sentrin/Small Ubiquitin-like Modifier (SUMO)-specific protea...
Disrupting the SHOC2-RAS Nexus: a new frontier in targeting RAS-Driven cancers [0.03%]
扰乱SHOC2-RAS连接：针对RAS驱动型癌症的新前沿靶点
Yudi Huang,Zhuoyang Chen,Shanqiang Qu
Yudi Huang