Cholesterol metabolism: molecular mechanisms, biological functions, diseases, and therapeutic targets [0.03%]
胆固醇代谢：分子机制、生物功能、疾病和治疗靶点
Daxin Cui,Xiaoqian Yu,Qiuyue Guan et al.
Daxin Cui et al.
Cholesterol, an indispensable structural and signaling lipid, is fundamental to cellular membrane integrity, steroidogenesis, and developmental morphogen pathways. Its homeostasis hinges on the precise coordination of four interdependent me...
Ruimin Bai,Yan Zheng,Xiaofeng Dai
Ruimin Bai
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by acute and chronic phases with no definitive cure currently available. The diagnosis of AD involves the evaluation of both disease onset and severity, relying on ...
Adipose-Derived Stem Cell Therapy Attenuates HIF-1α/mTOR/REDD1 Signaling in Obese Hypertensive Rats [0.03%]
脂肪来源干细胞通过抑制肥胖高血压大鼠HIF-1α/mTOR/REDD1信号通路发挥治疗作用
Renata Nakamichi,Mario Luis Ribeiro Cesaretti,Eric Rafael Andrade Silva et al.
Renata Nakamichi et al.
Adipose-Derived Stem Cell Therapy Attenuates HIF-1α/mTOR/REDD1 Signaling in Obese Hypertensive Rats [0.03%]
脂肪来源干细胞通过下调肥胖高血压大鼠HIF-1α/mTOR/REDD1信号通路发挥治疗作用
Renata Nakamichi,Mario Luis Ribeiro Cesaretti,Eric Rafael Andrade Silva et al.
Renata Nakamichi et al.
Iron accumulation in hypothalamus promotes age-dependent obesity and metabolic dysfunction of male mice [0.03%]
铁沉积通过促进雄性小鼠年龄相关的肥胖和代谢紊乱来促进衰老
Xinyu Wang,Xiaoyue Xiong,Ye Xuan et al.
Xinyu Wang et al.
With the progression of aging, age-dependent obesity and metabolic disorders have garnered increasing attention, yet their underlying mechanisms remain poorly understood. Dysregulation of iron homeostasis is strongly linked to aging; howeve...
5-Hydroxytryptamine promotes non-small cell lung cancer metastasis via the SNRPG/WT1/CDK14 Axis [0.03%]
5-羟色胺通过SNRPG/WT1/CDK14轴促进非小细胞肺癌转移
Jinzhe Sun,Chen-Guang Liu,Shiqian Chen et al.
Jinzhe Sun et al.
Tumor metastasis severely compromises the prognosis of patients with non-small cell lung cancer (NSCLC), yet the underlying mechanisms remain unclear. The biogenic amine 5-hydroxytryptamine (5-HT), derived from tryptophan (Trp), has been re...
Sero-neutralizing antibody against orthopoxviruses in populations of Wuhan, China [0.03%]
中国武汉市人群正痘病毒中和抗体血清流行率调查
Zhiqiang Gao,Tianyu Liu,Zhenghao Zhao et al.
Zhiqiang Gao et al.
The m6A modification in cancer: roles, implications, and its potential in therapy [0.03%]
m6A修饰在癌症中的作用、意义及治疗潜力
Yuyao Wei,Yang Wu,Chun Zhang et al.
Yuyao Wei et al.
N6-methyladenosine (m6A) serves as the dominant epitranscriptomic mark within eukaryotic mRNA transcripts, exerting pivotal regulatory functions in modulating mRNA structural integrity, translational efficiency, and splicing, thereby influe...
Single-cell RNA sequencing identifies CD8Teff cell activation as a predictive biomarker in triple-negative breast cancer immunotherapy [0.03%]
单细胞RNA测序揭示CD8Teff细胞活化作为三阴性乳腺癌免疫治疗的预测生物标志物
Luhui Mao,Zebang Zhang,Yongjian Chen et al.
Luhui Mao et al.
Immunotherapy has emerged as a promising treatment option for triple-negative breast cancer (TNBC); however, the pronounced heterogeneity of the tumor immune microenvironment significantly hinders the prediction of therapeutic efficacy, wit...
Circulating tumor DNA as a marker of molecular residual disease in resected esophageal squamous cell carcinoma [0.03%]
食管鳞癌手术切除标本中循环肿瘤DNA分子残留病灶的标志物价值研究
Cai-Yan Fang,Jing Wen,Jia-Di Wu et al.
Cai-Yan Fang et al.
Esophageal squamous cell carcinoma (ESCC) remains a major contributor to cancer-related mortality, with molecular residual disease (MRD) detection posing a significant challenge in post-surgical management. This study aimed to evaluate the ...