WNT signaling in cancer: molecular mechanisms and potential therapies [0.03%]
Wnt信号通路在癌症中的作用：分子机制与潜在治疗策略
Jiaqi Liang,Yiming Pan,Jingru Yang et al.
Jiaqi Liang et al.
The WNT signaling pathway, a fundamental molecular network regulating cell proliferation, differentiation, and stemness, plays a critical role in tumorigenesis, cancer progression, and therapeutic resistance. Given its crucial regulatory ro...
Single-cell multi-omics in biliary tract cancers: decoding heterogeneity, microenvironment, and treatment strategies [0.03%]
胆道癌症的单细胞多组学：解码异质性、微环境和治疗策略
Nannan Tang,Jiatong Li,Ao Gu et al.
Nannan Tang et al.
Biliary tract cancer (BTC) is a highly heterogeneous and aggressive gastrointestinal malignancy, marked by a high mortality rate and limited treatment efficacy. The primary contributing factors include the absence of reliable early detectio...
Targeting heat shock protein 90 with usnic acid relieves immune suppression via aryl hydrocarbon receptor-mediated mechanisms in lung cancer [0.03%]
通过芳烃受体介导的机制靶向热休克蛋白90以乌术酸缓解肺癌中的免疫抑制作用
Mücahit Varlı,Eun-Jung Ahn,Suresh R Bhosle et al.
Mücahit Varlı et al.
Immune evasion in lung cancer is closely associated with the dysregulation of molecular chaperones and immunoregulatory pathways. Heat shock protein 90 (HSP90), which is frequently overexpressed in lung cancer and correlates with poor progn...
Development of a trispecific fusion protein based on angiotensin-converting enzyme 2, glycoprotein 130, and tumor necrosis factor receptor 2 as a promising therapeutic for COVID-19 [0.03%]
基于血管紧张素转换酶2、糖蛋白130和肿瘤坏死因子受体2的三特异性融合蛋白作为治疗COVID-19的有前景的药物的研究开发进展
Yongfeng Qiao,Yanjun Han,Lu Zhao et al.
Yongfeng Qiao et al.
Despite a substantial reduction in the incidence of coronavirus disease 2019 (COVID-19) infections, severe cases continue to pose a significant clinical burden, particularly among elderly individuals and patients with underlying medical con...
Decoding the structure and translational promise of ROOL RNA nanocages [0.03%]
揭示ROOL RNA纳米笼的结构及其在蛋白质翻译中的作用
Hanqi Lou,Yuemin Ding,Shiwei Duan
Hanqi Lou
Healthy mitochondria attenuate metabolic dysfunction-associated steatohepatitis by restoring cell metabolism [0.03%]
健康线粒体通过恢复细胞代谢来缓解与代谢紊乱相关的肝炎
Peiyu Zhou,Jingli Li,Yafang Xie et al.
Peiyu Zhou et al.
Metabolic dysfunction-associated steatohepatitis (MASH) has become a major global health issue. Mitochondrial damage plays a crucial role in the development and progression of MASH. Therefore, it is speculated that mitochondrial transplanta...
Malate targets pyruvate kinase M2 to promote colorectal cancer cell cycle arrest and tumor suppression [0.03%]
马来酸靶向丙酮酸激酶同工酶M2诱导结直肠癌细胞周期阻滞和抑瘤作用
Kun Zhao,Fan Zhang,Qing Qin et al.
Kun Zhao et al.
To survive nutrient stress caused by rapid proliferation and dysfunctional vasculature, tumor cells extensively reprogram their metabolic pathways, including the tricarboxylic acid (TCA) cycle representing a critical remodeling node. Functi...
Lipin3 deficiency promotes hepatocyte ferroptosis and pyroptosis via activating JAK1-STAT3 pathway during acetaminophen induced acute liver injury [0.03%]
脂蛋白脂酶3缺乏通过激活JAK1-STAT3通路促进阿司匹林致急性肝损伤时的肝细胞铁死亡和焦亡
Yu-Xing Liu,Qian Wang,Zi-Yu Xiangyang et al.
Yu-Xing Liu et al.
Lipin3 belongs to the Lipin protein family and is pivotal in modulating lipid homeostasis, inflammatory signaling, and lineage commitment. However, research on Lipin3 is limited, and its role in liver diseases remains poorly defined. This s...
Moyamoya disease: epidemiology, clinical features, pathogenesis, diagnosis and therapeutic interventions [0.03%]
moyamoya病的流行病学、临床特点、发病机制、诊断及治疗方法
Xinyue Cheng,Ying Cao,Junbo Duan et al.
Xinyue Cheng et al.
Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by progressive stenosis of the intracranial internal carotid arteries and the development of compensatory, fragile collateral vascular networks at the skull. Emerging e...
15-lipoxygenase blockade switches off pan-organ ischaemia-reperfusion injury by inhibiting pyroptosis [0.03%]
15-脂氧合酶抑制通过抑制细胞焦亡切换器官缺血再灌注损伤
Jie Li,Hailong Zhang,Mengmeng Dai et al.
Jie Li et al.
Even with reperfusion therapy, ischemia-reperfusion (I/R) injury remains to be a major driver of organ failure associated with myocardial infarction, stroke, and liver transplantation, with effective therapeutic targets still elusive. Using...