The role of Nrf2 in anoikis resistance and metastasis in anaplastic thyroid carcinoma [0.03%]
Nrf2在未分化甲状腺癌中对细胞脱离诱导的凋亡抵抗及转移的作用研究
Simiao Fan,Huangcan Li,Ke Li et al.
Simiao Fan et al.
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive endocrine malignancies, characterized by rapid progression, extensive metastasis, and extremely poor prognosis. Despite advances in molecular oncology, the mechanisms driving ...
Itaconate reduces viral endocytosis by targeting Cys128 of the adaptor-related protein complex 1 gamma 1 subunit in the host, providing a novel target for antiviral drug development [0.03%]
岩藻糖通过靶向宿主的适应相关蛋白复合物1γ1链半胱氨酸128来减少病毒感染，为抗病毒药物开发提供了新思路
Xinqi Deng,Heng Chen,Zhixing Huang et al.
Xinqi Deng et al.
Traditional antiviral strategies primarily rely on vaccines and virus protein-targeting drugs, which adopt a virus-targeting approach. However, the rapid mutation of viruses often leads to vaccine failure and drug resistance, highlighting t...
Clinical-grade AI model for molecular subtyping of endometrial cancer: a multi-center cohort study in China [0.03%]
中国多中心子宫内膜癌分子分型临床级人工智能模型研究
Peng Qi,Tianliang Yao,Hu Li et al.
Peng Qi et al.
Accurate molecular subtyping is essential for guiding precision treatment and prognostic stratification in endometrial cancer (EC). However, current methods, based on Sanger sequencing and immunohistochemistry (IHC), are costly, time-intens...
Targeting ferroptosis and cuproptosis in gastrointestinal cancers: molecular mechanisms, metabolic vulnerabilities, and therapeutic interventions [0.03%]
胃肠癌症中铁死亡和铜死亡的靶向治疗：分子机制、代谢弱点及治疗干预措施
Yang Zhang,Yixiang Gu,Ming Zhan et al.
Yang Zhang et al.
Gastrointestinal (GI) malignancies represent a significant global health burden, characterized by high mortality rates and profound resistance to conventional therapies. This necessitates the exploration of novel therapeutic vulnerabilities...
Xingling Li,Haiqing Xiao,Ming Zhou et al.
Xingling Li et al.
The pandemics of respiratory viruses pose a worldwide public health problem and bio-safety threat. Therefore, the development of high-throughput and accurate infection models is crucial for elucidating viral pathogenesis and accelerating co...
Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets [0.03%]
生物分子凝聚体：分子结构、生物学功能、疾病与治疗靶点
Sunkyung Choi,Jung-Min Lee,Kee K Kim
Sunkyung Choi
Cells constantly encounter environmental and physiological fluctuations that challenge homeostasis and threaten viability. In response to these cues, specific proteins and nucleic acids engage in multivalent interactions and undergo phase s...
Endoplasmic reticulum-resident protein DNAJC10 inhibits glioblastoma metastasis by suppressing XBP-1s-driven EGFR transcription [0.03%]
内质网驻留蛋白DNAJC10通过抑制XBP-1s驱动的EGFR转录来抑制胶质母细胞瘤转移
Erdi Zhao,Yue Yu,Yingli Gao et al.
Erdi Zhao et al.
Glioblastoma (GBM) is characterized by the highly infiltrative growth of cancer cells into the surrounding brain parenchyma. DnaJ Heat Shock Protein Family (Hsp40) Member C10 (DNAJC10, also known as ERDJ5 and PDIA19), involved in endoplasmi...
Xubin Zhang,Yongsheng Liang,Fayao Zhang et al.
Xubin Zhang et al.
Osteoporosis is a systemic skeletal disease. Genetic and environmental factors work together to cause increased bone resorption, decreased bone formation, bone remodeling imbalance, reduced bone mass, and increased bone fragility. The globa...
Jie Shen,Bin Liao,Li Gong et al.
Jie Shen et al.
Cluster of differentiation 39 (CD39) and CD73 are ectonucleotidases that play pivotal roles in purinergic signaling. CD39 catalyzes the hydrolysis of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) and subsequently to adenosine ...
Decoding LAG3 activation: ubiquitination liberates immunosuppressive motif to license checkpoint function [0.03%]
解码LAG3的激活作用：泛素化释放免疫抑制基序以启动检查点功能
Tong Zhang,Feng Xie,Fangfang Zhou
Tong Zhang