PARP inhibitor BMN673 triggers PARylation-mediated ATF4-GDF15 pathway to drive autophagy and ferroptosis in ataxia telangiectasia mutated gene-deficient colorectal cancer cells [0.03%]
PARP抑制剂BMN673通过ATF4-GDF15轴诱导自噬及铁死亡杀伤ATM缺陷的结直肠癌细胞
Junqi Xiang,Jie Xu,Hui Fan et al.
Junqi Xiang et al.
Colorectal cancer (CRC) is a serious threat to human health, with an approximate 14% mutation rate in the ataxia telangiectasia-mutated (ATM) gene, which is involved in homologous recombination repair. BMN673 (talazoparib), a next-generatio...
Drug resistance in cancer: molecular mechanisms and emerging treatment strategies [0.03%]
癌症药物抗性：分子机制与治疗策略的发展
Jinxin Li,Jiatao Hu,Yiren Yang et al.
Jinxin Li et al.
Therapeutic resistance remains a defining challenge in oncology, limiting the durability of current therapies and contributing to disease relapse and poor patient outcomes. This review systematically integrates recent progress in understand...
Histone methyltransferase KMT2D targets the SPOP-G3BP1 axis to enhance AR stability and drive castration-resistant prostate cancer progression [0.03%]
组蛋白甲基转移酶KMT2D靶向SPOP-G3BP1轴以增强AR稳定性并驱动去势抵抗性前列腺癌进展
Haoran Wen,Maierhaba Maheremu,Kaidi Zhang et al.
Haoran Wen et al.
Castration-resistant prostate cancer (CRPC) poses a significant clinical challenge, characterized by limited therapeutic options and unfavorable prognosis, particularly among elderly men. Reactivation of androgen receptor (AR) signaling rem...
ER stress induced extracellular vesicles secretion from macrophages promotes calcium oxalate crystals formation in kidney [0.03%]
由内质网压力诱导的巨噬细胞来源的外泌体促进肾内草酸钙晶体沉积
Yiqiong Yuan,Yucheng Ma,Lunzhi Dai et al.
Yiqiong Yuan et al.
Macrophages are involved in the development of kidney stone disease, and substantial research suggests that macrophage-derived extracellulr vesicles (Mφ-EVs) may play a pivotal role in this process. However, the impact of Mφ-EVs on kidney...
Minyi Cai,Haiyan Liu,Chen Shao et al.
Minyi Cai et al.
Cancer is a leading cause of death worldwide. Metabolic reprogramming in cancers plays an important role in tumor initiation, malignant progression and therapeutic response. Based on this, significant progress has been made in the developme...
ML345 is a potent and selective NLRP3 inflammasome inhibitor with anti-inflammatory activity [0.03%]
ML345是一种有效的NLRP3炎症小体抑制剂，并具有抗炎活性
Hualong Lin,Xinxin Liang,Weijie Hao et al.
Hualong Lin et al.
Excessive activation of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome plays a key role in the pathogenesis of various inflammatory diseases. Despite the development of several NLRP3 inhibitors, no specific the...
Osteopontin promoted cardiac inflammation through increased interleukin-12 in acute myocarditis [0.03%]
骨基质蛋白促进急性心肌炎中心肌炎症的机制研究
Xiang Nie,Jiahui Fan,Yatong Qin et al.
Xiang Nie et al.
Osteopontin (OPN) is a multifunctional glycoprotein known to play critical roles in autoimmunity and tissue repair, yet its function in acute viral myocarditis remains poorly understood. To systematically investigate the pathogenesis of vir...
Structural and Functional Basis for Biased Agonism at the 5-hydroxytryptamine 5A Receptor [0.03%]
5-羟色胺5A受体偏置激动剂的结构和功能基础
Xiaoyu Zhang,Linshan Xie,Peipei Chen et al.
Xiaoyu Zhang et al.
STAT3 regulates NK and NKT cell differentiation through C-X3-C motif chemokine receptor 1 (CX3CR1) in hyper-IgE syndrome [0.03%]
STAT3通过C-X3-C基序趋化因子受体1（CX3CR1）调节高IgE综合征中的NK和NKT细胞分化
Ju Liu,Jingzhi Yang,Jianing Tang et al.
Ju Liu et al.
Mutations in the signal transducer and activator of transcription 3 (STAT3) gene are strongly associated with Hyper-IgE Syndrome (HIES), a rare immunodeficiency disorder characterized by elevated levels of IgE and recurrent infections. The ...
E3 ligase CHIP restoration facilitates the effect of α1-adrenoceptor blockage on alleviating lipopolysaccharide-caused cardiac fibrosis via downregulating TGF-BR1 expression and Smad2/3 activation [0.03%]
E3连接酶CHIP的恢复通过下调TGF-βR1表达和Smad2/3活化促进α1-肾上腺素受体阻滞剂对脂多糖引起的心脏纤维化的缓解作用
Wan Lin,Hang Li,Hin Fong et al.
Wan Lin et al.
Myocardial fibrosis is a serious complication in sepsis and leads to cardiac dysfunction. The carboxy terminus of Hsc70-interacting protein (CHIP), a U-box E3 ligase, defends against sepsis-caused cardiac injury. Here, we explored a novel t...