T-cell immunoglobulin and mucin domain-containing protein 3-mediated immunomodulation in myeloid cells and keratinocytes in the development of severe acne [0.03%]
髓系细胞和角质形成细胞中T细胞免疫球蛋白和黏蛋白结构域蛋白3介导的免疫调节在重度痤疮发生中的作用
Siliang Chen,Xiaoyun Wang,Yidan Xu et al.
Siliang Chen et al.
Acne vulgaris is a common chronic inflammatory skin disorder with significant clinical and societal impacts. Severe acne (SA), in particular, causes scarring, disfigurement, and psychosocial distress. The underlying pathogenesis of SA remai...
Ubiquitin-specific protease 13 promotes colorectal cancer progression by stabilizing mitogen-activated protein kinase kinase 3 [0.03%]
泛素特异性蛋白酶13通过稳定丝裂原活化蛋白激酶激酶3促进结直肠癌进展
Si-Yu Chang,Bo Gu,Yong Xiong et al.
Si-Yu Chang et al.
The deubiquitinase ubiquitin-specific protease 13 (USP13) has been implicated in various cancers, yet its precise molecular function and clinical significance in colorectal cancer (CRC) remain poorly defined. Here, we identify USP13 as a cr...
MIRA-1, a p53mut reactivator, is active on Temozolomide-resistant glioblastoma in vitro [0.03%]
MIRA-1（p53mut活化剂）对替莫唑胺耐药的胶质母细胞瘤具有体外活性
Juan Perdomo,Catherine Gratas,François Paris et al.
Juan Perdomo et al.
Obestatin treatment links mitochondrial homeostasis and skeletal muscle repair in Duchenne muscle dystrophy [0.03%]
obestatin治疗链接线粒体稳态和杜氏肌营养不良的骨骼肌修复
Andrea C Lodeiro,Silvia Costas-Abalde,Tania Cid-Díaz et al.
Andrea C Lodeiro et al.
Duchenne muscular dystrophy (DMD) is a genetic, progressive neuromuscular disease caused by mutations in the dystrophin protein which compromise the integrity of the sarcolemma. Current care of DMD involves both supportive and targeted dise...
Long-chain acyl-CoA synthetases: biological functions, diseases and therapeutic targets [0.03%]
长链酰基辅酶a合成酶：生物学功能、疾病和治疗靶点
Xiaoliang Deng,Yanqun Luo,Ying Gao et al.
Xiaoliang Deng et al.
The long-chain acyl-CoA synthetase (ACSL) family comprises key enzymes that are integral to the fatty acid metabolic pathway and play crucial roles in governing fatty acid (FA) metabolism and lipid homeostasis. These enzymes are involved in...
Computer-aided design enables repurposing of proprotein convertase subtilisin/kexin type 9 degrader from cholesterol-lowering to colon cancer therapy [0.03%]
计算机辅助设计使前蛋白转化酶枯草杆菌肽/kexin IX降解剂从降低胆固醇转向治疗结直肠癌成为可能
Gang Fan,Jinhui Zha,Shilin Chen et al.
Gang Fan et al.
Cardiac atrophy associated to cancer: new perspectives in signaling pathways [0.03%]
癌症相关心脏萎缩：信号通路的新视角
Andrea C Lodeiro,Saúl Leal-López,Silvia Costas-Abalde et al.
Andrea C Lodeiro et al.
Epithelial membrane protein 1 drives hepatic stellate cell activation via the TLN1/FAK cascade in MASLD donor liver transplantation [0.03%]
上皮膜蛋白1通过TLN1/FAK级联反应驱动MASLD供体肝移植中的肝星状细胞活化
Tongxi Li,Ran Liu,Huan Cao et al.
Tongxi Li et al.
The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) has significantly increased, prompting the increased use of steatotic donor livers in transplantation, contributing to a higher incidence and severity of isc...
Multi-omics strategies for biomarker discovery and application in personalized oncology [0.03%]
多组学策略在肿瘤个体化医疗生物标志物发现和应用中的作用
Ziming Jiang,Haoxuan Zhang,Yibo Gao et al.
Ziming Jiang et al.
Multi-omics strategies, integrating genomics, transcriptomics, proteomics, and metabolomics, have revolutionized biomarker discovery and enabled novel applications in personalized oncology. Despite rapid technological developments, a compre...
A single non-coding SNP in FPGS modulates folate drug efficacy in acute lymphoblastic leukemia: data-driven exploration and experimental validation [0.03%]
一个单个的非编码SNP通过数据驱动探索和实验验证调节急性淋巴细胞白血病中叶酸药物疗效：在FPGS中的研究
Wenliang Yu,Chenyang Li,Yuning Meng et al.
Wenliang Yu et al.
For over 70 years, methotrexate (MTX) has remained a first-line chemotherapeutic agent for acute lymphoblastic leukemia (ALL), playing a pivotal role in maintenance therapy. Understanding the genetic determinants of MTX efficacy is therefor...