Leucine-rich pentatricopeptide repeat-containing protein (LRPPRC)-stabilized lncRNA small nucleolar RNA host gene 15 (Snhg15) modulates hematopoietic injury induced by γ-ray irradiation via m6A modification [0.03%]
脯氨酸丰富pentatricopeptide重复蛋白(LRPPRC)稳定的小核仁rna宿主基因15(Snhg15)通过m6A修饰调节γ射线照射引起的造血损伤
Shuqin Zhang,Yajia Cheng,Yujia Gao et al.
Shuqin Zhang et al.
With advancements in radiotherapy technologies, the detrimental effects of ionizing radiation on biological systems, particularly the hematopoietic system, have caused significant concern. N6-methyladenosine (m6A), the most pervasive repres...
Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer [0.03%]
果糖代谢及其在代谢性疾病、炎症性疾病和癌症中的作用
Zhenhong Li,Xinzou Fan,Fan Gao et al.
Zhenhong Li et al.
Fructose, a prevalent hexose, has become a widely used food additive, with its usage rising significantly because of socio-economic advancements and shifts in human dietary habits. Excessive fructose intake has been implicated in obesity, c...
Lilin Wang,Xiaoting Zhou,Tianqi Lu
Lilin Wang
Mitochondria are generally considered essential for life in eukaryotic organisms because they produce most of the energy or adenosine triphosphate (ATP) needed by the cell. Beyond energy production, it is now widely accepted that mitochondr...
Exosomes in inflammation and cancer: from bench to bedside applications [0.03%]
外泌体在炎症及癌症中的研究：从基础到临床应用
Shiyuan Huang,Fang Yan,Yi Qiu et al.
Shiyuan Huang et al.
Exosomes, lipid bilayer nanovesicles secreted by nearly all cell types, play pivotal roles in intercellular communication by transferring proteins, nucleic acids, and lipids. This review comprehensively summarizes their multiple functions i...
C-X-C motif chemokine ligand 1 derived from oral squamous cell carcinoma promotes cancer-associated fibroblast differentiation and tumor growth [0.03%]
来源于口腔鳞状细胞癌的C-X-C基序趋化因子配体1促进癌症相关成纤维细胞分化和肿瘤生长
Soon Chul Heo,In-Hye Nam,Bo Ram Keum et al.
Soon Chul Heo et al.
Cancer-associated fibroblasts (CAFs), the predominant stromal cells in the tumor microenvironment (TME), play a critical role in the progression of solid tumors, including oral squamous cell carcinoma (OSCC). However, the molecular mechanis...
Application of multigene panel testing for bleeding, thrombotic, and platelet disorders in patients and the general population in China [0.03%]
多基因检测在中国出血、血栓和血小板病患者的临床应用及在普通人群中的应用前景分析
Yaohua Cai,Wenyi Lin,Jun Deng et al.
Yaohua Cai et al.
Bleeding, thrombotic, and platelet disorders (BTPDs) are rare but complex conditions with diverse clinical presentations that often delay accurate diagnosis. In this study, we developed an Expanded Thrombohemostasis (ExTH) gene panel compri...
Histone and non-histone lactylation: molecular mechanisms, biological functions, diseases, and therapeutic targets [0.03%]
组蛋白和非组蛋白乳酰化：分子机制、生物学功能、疾病与治疗靶点
Xia Peng,Juan Du
Xia Peng
Lysine lactylation (Kla) is a recently discovered post‑translational modification in which a lactyl moiety is transferred onto the ε‑amino group of lysine residues, linking cellular metabolism to epigenetic and signaling pathways. This p...
The EZH2 selective inhibitor ZLD1039 attenuates UUO-induced renal fibrosis by suppressing YAP activation [0.03%]
EZH2选择性抑制剂ZLD1039通过抑制YAP活化减轻UUO诱导的肾纤维化
Qingling Xia,Fujiang Xu,Lidan Zhang et al.
Qingling Xia et al.
Renal fibrosis is a manifestation of the progression of chronic kidney disease (CKD) and chronic inflammation is a main driver in the development of renal fibrosis. Yes-associated protein (YAP), acting as a transcriptional co-activator with...
Transmembrane emp24 domain-containing protein 3 promotes the malignant progression of glioma by regulating the ZBTB7A signaling axis [0.03%]
跨膜EMP24结构域含有的蛋白3通过调节ZBTB7A信号轴促进胶质瘤的恶性进展
Yang Qiao,Lv Zhou,Jianyu Nie et al.
Yang Qiao et al.
Glioblastoma (GBM) is highly malignant with a poor prognosis. Exploring new therapeutic targets in GBM is an effective strategy for the prognosis of GBM patients. The Transmembrane emp24 domain-containing protein 3 (TMED3) gene has been fou...