Thomas A Rando,Tony Wyss-Coray
Thomas A Rando
Aging has largely been defined by analog measures of organ and organismal dysfunction. This has led to the characterization of aging processes at the molecular and cellular levels that underlie these gradual changes. However, current knowle...
Handan Melike Dönertaş,Daniel K Fabian,Matías Fuentealba Valenzuela et al.
Handan Melike Dönertaş et al.
Age is a common risk factor in many diseases, but the molecular basis for this relationship is elusive. In this study we identified 4 disease clusters from 116 diseases in the UK Biobank data, defined by their age-of-onset profiles, and fou...
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy [0.03%]
同龄人生理老化速度的差异对未来虚弱风险和政策的影响不容忽视
Maxwell L Elliott,Avshalom Caspi,Renate M Houts et al.
Maxwell L Elliott et al.
Some humans age faster than others. Variation in biological aging can be measured in midlife, but the implications of this variation are poorly understood. We tested associations between midlife biological aging and indicators of future fra...
Olfactory perception of food abundance regulates dietary restriction-mediated longevity via a brain-to-gut signal [0.03%]
嗅觉感知食物丰富度通过脑肠信号调节饮食限制介导的长寿
Bi Zhang,Heejin Jun,Jun Wu et al.
Bi Zhang et al.
The role of food nutrients in mediating the positive effect of dietary restriction (DR) on longevity has been extensively characterized, but how non-nutrient food components regulate lifespan is not well understood. Here, we show that food-...
Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice [0.03%]
lifelong限制支链氨基酸饮食具有性别特异性的改善小鼠体弱和寿命的好处
Nicole E Richardson,Elizabeth N Konon,Haley S Schuster et al.
Nicole E Richardson et al.
Protein restricted (PR) diets promote health and longevity in many species. While the precise components of a PR diet that mediate the beneficial effects to longevity have not been defined, we recently showed that many metabolic effects of ...
The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress [0.03%]
转录共激活因子CBP/p300是进化上保守的节点，在线粒体压力下促进长寿响应
Terytty Yang Li,Maroun Bou Sleiman,Hao Li et al.
Terytty Yang Li et al.
Organisms respond to mitochondrial stress by activating multiple defense pathways including the mitochondrial unfolded protein response (UPRmt). However, how UPRmt regulators are orchestrated to transcriptionally activate stress responses r...