Altered Chromatin States Drive Cryptic Transcription in Aging Mammalian Stem Cells [0.03%]
改变的染色质状态驱动老化哺乳动物干细胞中的隐蔽转录
Brenna S McCauley,Luyang Sun,Ruofan Yu et al.
Brenna S McCauley et al.
A repressive chromatin state featuring trimethylated lysine 36 on histone H3 (H3K36me3) and DNA methylation suppresses cryptic transcription in embryonic stem cells. Cryptic transcription is elevated with age in yeast and nematodes, and red...
Glial AP1 is activated with aging and accelerated by traumatic brain injury [0.03%]
胶质细胞AP1 活化与年龄增长相关并能被脑外伤加速
China N Byrns,Janani Saikumar,Nancy M Bonini
China N Byrns
The emergence of degenerative disease after traumatic brain injury is often described as an acceleration of normal age-related processes. Whether similar molecular processes occur after injury and in age is unclear. Here we identify a funct...
It takes knowledge to transform the world to be a better place to grow older [0.03%]
改变世界使他成为适合变老的地方需要知识
Tedros Adhanom Ghebreyesus
Tedros Adhanom Ghebreyesus
In support of the Decade of Healthy Aging, the World Health Organization has launched a publicly available, multi-lingual knowledge exchange platform that will enable people to find, share and produce knowledge on healthy aging. The WHO Dir...
It takes knowledge to transform the world to be a better place to grow older [0.03%]
用知识把世界变得更好老龄化的地方
Tedros Adhanom Ghebreyesus
Tedros Adhanom Ghebreyesus
In support of the Decade of Healthy Aging, the World Health Organization has launched a publicly available, multi-lingual knowledge exchange platform that will enable people to find, share and produce knowledge on healthy aging. The WHO Dir...
Multi-omic profiling of primary mouse neutrophils predicts a pattern of sex and age-related functional regulation [0.03%]
小鼠中性粒细胞的多组学分析预测了功能调节的性别和年龄相关模式
Ryan J Lu,Shalina Taylor,Kévin Contrepois et al.
Ryan J Lu et al.
Neutrophils are the most abundant human white blood cell and constitute a first line of defense in the innate immune response. Neutrophils are short-lived cells, and thus the impact of organismal aging on neutrophil biology, especially as a...
The physical frailty syndrome as a transition from homeostatic symphony to cacophony [0.03%]
虚弱症作为一种从机体稳态的“和谐”到“不和谐”的过渡现象
Linda P Fried,Alan A Cohen,Qian-Li Xue et al.
Linda P Fried et al.
Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence on the aging-related pathophysiology underpinning the clinica...
Restoration of SIRT3 gene expression by airway delivery resolves age-associated persistent lung fibrosis in mice [0.03%]
气管递送SIRT3基因表达的恢复可缓解小鼠年龄相关的持续性肺纤维化
Mohammad Rehan,Deepali Kurundkar,Ashish R Kurundkar et al.
Mohammad Rehan et al.
Aging is a risk factor for progressive fibrotic disorders involving diverse organ systems, including the lung. Idiopathic pulmonary fibrosis, an age-associated degenerative lung disorder, is characterized by persistence of apoptosis-resista...
William A Banks,May J Reed,Aric F Logsdon et al.
William A Banks et al.
The blood-brain barrier (BBB) protects the central nervous system (CNS) from unregulated exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain-to-blood permeation of many substances, resulting in nourish...
Recent trends and increasing differences in life expectancy present opportunities for multidisciplinary research on aging [0.03%]
近年来预期寿命趋势分化为跨学科衰老研究提供契机
Eileen M Crimmins
Eileen M Crimmins
The increase in multidisciplinary research in the field of aging has many benefits and should be further applied to better understand and possibly reverse the stalled increase in life expectancy as well as growing social inequalities in lif...
KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype [0.03%]
KDM4通过表观基因重编程衰老细胞并促进衰老相关分泌表型产生
Boyi Zhang,Qilai Long,Shanshan Wu et al.
Boyi Zhang et al.
Cellular senescence restrains the expansion of neoplastic cells through several layers of regulation. We report that the histone H3-specific demethylase KDM4 is expressed as human stromal cells undergo senescence. In clinical oncology, upre...