Dysregulation of mitochondrial and proteolysosomal genes in Parkinson's disease myeloid cells [0.03%]
帕金森病髓样细胞中线粒体和蛋白酶溶酶体基因失调
Elisa Navarro,Evan Udine,Katia de Paiva Lopes et al.
Elisa Navarro et al.
An increasing number of identified Parkinson's disease (PD) risk loci contain genes highly expressed in innate immune cells, yet their role in pathology is not understood. We hypothesize that PD susceptibility genes modulate disease risk by...
Paloma Navarro Negredo,Anne Brunet
Paloma Navarro Negredo
Groh and colleagues investigate the age-related degeneration of axons in the optic nerve and other brain regions and show that at least part of this degeneration is due to the presence of T cells.
Yahyah Aman,Tomas Schmauck-Medina,Malene Hansen et al.
Yahyah Aman et al.
Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development...
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging [0.03%]
基于深度学习的炎症性衰老时钟(iAge)追踪多病共存、免疫衰老、脆弱和心血管老化
Nazish Sayed,Yingxiang Huang,Khiem Nguyen et al.
Nazish Sayed et al.
While many diseases of aging have been linked to the immunological system, immune metrics capable of identifying the most at-risk individuals are lacking. From the blood immunome of 1,001 individuals aged 8-96 years, we developed a deep-lea...
Short-term air pollution, cognitive performance, and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study [0.03%]
短期空气污染、认知表现和非甾体抗炎药在退伍军人规范老化研究中的使用
Xu Gao,Brent Coull,Xihong Lin et al.
Xu Gao et al.
Air pollution, especially the fine particulate matter (PM2.5), may impair cognitive performance1-3, but its short-term impact remains poorly understood. We investigated the short-term associations of PM2.5 with the cognitive performances of...
Nathan S Gasek,George A Kuchel,James L Kirkland et al.
Nathan S Gasek et al.
Cellular senescence represents a distinct cell fate characterized by replicative arrest in response to a host of extrinsic and intrinsic stresses. Senescence provides programming during development and wound healing, while limiting tumorige...
Dissociable effects of APOE-ε4 and β-amyloid pathology on visual working memory [0.03%]
APOE-ε4和β-淀粉样病理学对视觉工作记忆的可分离影响
Kirsty Lu,Jennifer M Nicholas,Yoni Pertzov et al.
Kirsty Lu et al.
Although APOE-ε4 carriers are at significantly higher risk of developing Alzheimer's disease than non-carriers1, controversial evidence suggests that APOE-ε4 might confer some advantages, explaining the survival of this gene (antagonistic...
Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome [0.03%]
经典人类单核细胞的增强型表观遗传分析揭示了DNA甲基化组中健康衰老的特异性标记
Irina Shchukina,Juhi Bagaitkar,Oleg Shpynov et al.
Irina Shchukina et al.
The impact of healthy aging on molecular programming of immune cells is poorly understood. Here, we report comprehensive characterization of healthy aging in human classical monocytes, with a focus on epigenomic, transcriptomic, and proteom...
Juliet M Bartleson,Dina Radenkovic,Anthony J Covarrubias et al.
Juliet M Bartleson et al.
The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with particular risk for severe disease and death in older adults and in adults with age-related metabolic and cardiovascular disease. Recent advances in the science...
Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis [0.03%]
衰老细胞抑制动脉粥样硬化中平滑肌细胞的内在修复功能
Bennett G Childs,Cheng Zhang,Fahad Shuja et al.
Bennett G Childs et al.
Senescent cells (SNCs) degenerate the fibrous cap that normally prevents atherogenic plaque rupture, a leading cause of myocardial infarction and stroke. Here we explored the underlying mechanism using pharmacological or transgenic approach...