Long-term prognosis and educational determinants of brain network decline in older adult individuals [0.03%]
老年个体长期预后及教育决定因素的脑网络衰退研究
Micaela Y Chan,Liang Han,Claudia A Carreno et al.
Micaela Y Chan et al.
Older adults with lower education are at greater risk for dementia. It is unclear which brain changes lead to these outcomes. Longitudinal imaging-based measures of brain structure and function were examined in adult individuals (baseline a...
DNA methylation clocks tick in naked mole rats but queens age more slowly than nonbreeders [0.03%]
裸鼹鼠的DNA甲基化钟存在但与普通个体相比繁殖 queen 的衰老速度更慢
Steve Horvath,Amin Haghani,Nicholas Macoretta et al.
Steve Horvath et al.
Naked mole rats (NMRs) live an exceptionally long life, appear not to exhibit age-related decline in physiological capacity and are resistant to age-related diseases. However, it has been unknown whether NMRs also evade aging according to a...
Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers [0.03%]
线粒体功能异常的肌肉干细胞促进肌纤维融合蛋白质 Scinderin 的作用
Xun Wang,Spencer D Shelton,Bogdan Bordieanu et al.
Xun Wang et al.
Muscle stem cells (MuSCs) experience age-associated declines in number and function, accompanied by mitochondrial electron transport chain (ETC) dysfunction and increased reactive oxygen species (ROS). The source of these changes, and how M...
Valter D Longo,Maira Di Tano,Mark P Mattson et al.
Valter D Longo et al.
Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to affect longevity and healthspan by acting on cellular aging and disease risk factors, while causing no or minor side effects. IF lasting from 12 ...
APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β [0.03%]
APOE4通过环孢子蛋白A加速老年阿尔茨海默病小鼠晚期血管和神经退行性疾病，独立于淀粉样蛋白-β的作用
Axel Montagne,Angeliki M Nikolakopoulou,Mikko T Huuskonen et al.
Axel Montagne et al.
Apolipoprotein E4 (APOE4), the main susceptibility gene for Alzheimer's disease (AD), leads to vascular dysfunction, amyloid-β pathology, neurodegeneration and dementia. How these different pathologies contribute to advanced-stage AD remai...
Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations [0.03%]
携带BRCA1或BRCA2种系突变女性乳腺上皮加速衰老的证据
Sundus F Shalabi,Masaru Miyano,Rosalyn W Sayaman et al.
Sundus F Shalabi et al.
During aging in the human mammary gland, luminal epithelial cells lose lineage fidelity by expressing markers normally expressed in myoepithelial cells. We hypothesize that loss of lineage fidelity is a general manifestation of epithelia th...
Perspective: Modulating the integrated stress response to slow aging and ameliorate age-related pathology [0.03%]
调控整合应激反应以减缓衰老和改善与年龄相关的病理损伤
Maxime J Derisbourg,Matías D Hartman,Martin S Denzel
Maxime J Derisbourg
Healthy aging requires the coordination of numerous stress signaling pathways that converge on the protein homeostasis network. The Integrated Stress Response (ISR) is activated by diverse stimuli, leading to phosphorylation of the eukaryot...
Laura L Carstensen,Kevin Chi
Laura L Carstensen
A new study provides broad evidence that older people are more generous than their younger counterparts, but that they favor local over global giving. In light of population aging and the relative wealth controlled by older citizens, it is ...
Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer's Disease Models [0.03%]
端粒酶逆转录酶可保护阿尔茨海默病模型中的神经元存活和认知能力
Hong Seok Shim,James W Horner,Chang-Jiun Wu et al.
Hong Seok Shim et al.
Amyloid-induced neurodegeneration plays a central role in Alzheimer's disease (AD) pathogenesis. Here, we show that telomerase reverse transcriptase (TERT) haploinsufficiency decreases BDNF and increases amyloid-β (Aβ) precursor in murine...
An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo [0.03%]
一种可在活体中监测和操控p21高表达衰老细胞的可诱导型p21-Cre小鼠模型
Binsheng Wang,Lichao Wang,Nathan S Gasek et al.
Binsheng Wang et al.
The role of senescent cells has been implicated in various tissue dysfunction associated with aging, obesity, and other pathological conditions. Currently, most transgenic mouse models only target p16 Ink4a-highly-expressing (p16 high) cell...