Cassandra J McGill,Bérénice A Benayoun
Cassandra J McGill
While investigating sex-differences in T-cell aging, Mkhikian et al., identified a role for excessive IL-7 signaling and N-glycan branching in age-related mouse and human female T-cell dysfunction. These findings point to the increasingly-r...
Xu Zhang,Leena Habiballa,Zaira Aversa et al.
Xu Zhang et al.
Senescence is a cell fate that contributes to multiple aging-related pathologies. Despite profound age-associated changes in skeletal muscle (SkM), whether its constituent cells are prone to senesce has not been methodically examined. Herei...
Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity [0.03%]
单个人体心肌细胞中的体细胞性突变揭示了与年龄相关的DNA损伤和普遍的氧化基因毒性
Sangita Choudhury,August Yue Huang,Junho Kim et al.
Sangita Choudhury et al.
The accumulation of somatic DNA mutations over time is a hallmark of aging in many dividing and nondividing cells but has not been studied in postmitotic human cardiomyocytes. Using single-cell whole-genome sequencing, we identified and cha...
Imagining a Personalized Scenario Selectively Increases Perceived Risk of Viral Transmission for Older Adults [0.03%]
构想个性化场景可以增加老年人对病毒传播风险的感知
Alyssa H Sinclair,Matthew L Stanley,Shabnam Hakimi et al.
Alyssa H Sinclair et al.
The COVID-19 pandemic has created a serious and prolonged public-health emergency. Older adults have been at substantially greater risk of hospitalization, ICU admission, and death due to COVID-19; as of February 2021, over 81% of COVID-19-...
Rethinking the urban physical environment for century-long lives: from age-friendly to longevity-ready cities [0.03%]
重构长寿时代的城市物理环境：从适老城市到长寿城市
Chenghao Wang,Diego Sierra Huertas,John W Rowe et al.
Chenghao Wang et al.
In response to increasing life expectancies and urbanization, initiatives for age-friendly cities seek to facilitate active and healthy aging by strengthening supports and services for older people. While laudable, these efforts typically n...
David A Ziegler,Joaquin A Anguera,Courtney L Gallen et al.
David A Ziegler et al.
As population aging advances at an increasing rate, efforts to help people maintain or improve cognitive function late in life are critical. Although some studies have shown promise, the question of whether cognitive training is an effectiv...
Regulation of aged skeletal muscle regeneration by circulating extracellular vesicles [0.03%]
循环细胞外囊泡调节衰老肌肉再生
Amrita Sahu,Zachary J Clemens,Sunita N Shinde et al.
Amrita Sahu et al.
Heterochronic blood exchange (HBE) has demonstrated that circulating factors restore youthful features to aged tissues. However, the systemic mediators of those rejuvenating effects remain poorly defined. We show here that the beneficial ef...
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease [0.03%]
基于内表型的计算网络药物发现与保险记录数据挖掘相结合，识别出西地那非可能是阿尔茨海默病的候选药物
Jiansong Fang,Pengyue Zhang,Yadi Zhou et al.
Jiansong Fang et al.
We developed an endophenotype disease module-based methodology for Alzheimer's disease (AD) drug repurposing and identified sildenafil as a potential disease risk modifier. Based on retrospective case-control pharmacoepidemiologic analyses ...
Randomized Controlled Trial
Nature aging. 2021 Dec;1(12):1175-1188. DOI:10.1038/s43587-021-00138-z 2021
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology [0.03%]
人脑中衰老细胞的特征鉴定揭示出CDKN2D/p19和tau蛋白病理性神经元
Shiva Kazempour Dehkordi,Jamie Walker,Eric Sah et al.
Shiva Kazempour Dehkordi et al.
Senescent cells contribute to pathology and dysfunction in animal models1. Their sparse distribution and heterogenous phenotype have presented challenges for detecting them in human tissues. We developed a senescence eigengene approach to i...
Age-associated impairment of T cell immunity is linked to sex-dimorphic elevation of N-glycan branching [0.03%]
年龄相关的T细胞免疫功能损伤与N-聚糖分支增强有关且具有性别差异性
Haik Mkhikian,Ken L Hayama,Khachik Khachikyan et al.
Haik Mkhikian et al.
Impaired T cell immunity with aging increases mortality from infectious disease. The branching of Asparagine-linked glycans is a critical negative regulator of T cell immunity. Here we show that branching increases with age in females more ...