Mitochondria-enriched hematopoietic stem cells exhibit elevated self-renewal capabilities, thriving within the context of aged bone marrow [0.03%]
线粒体富集的造血干细胞表现出增强的自我更新能力，在老化骨髓中也能繁荣生长
Haruhito Totani,Takayoshi Matsumura,Rui Yokomori et al.
Haruhito Totani et al.
The aging of hematopoietic stem cells (HSCs) substantially alters their characteristics. Mitochondria, essential for cellular metabolism, play a crucial role, and their dysfunction is a hallmark of aging-induced changes. The impact of mitoc...
Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination [0.03%]
单细胞免疫老化时钟揭示感染和接种疫苗期间个体间的异质性
Wenchao Li,Zhenhua Zhang,Saumya Kumar et al.
Wenchao Li et al.
Aging affects human immune system functionality, increasing susceptibility to immune-mediated diseases. While gene expression programs accurately reflect immune function, their relationship with biological immune aging and health status rem...
Lucrezia A Trastus,Fabrizio d&#x;Adda di Fagagna
Lucrezia A Trastus
Cancer is an age-related disease, but the interplay between cancer and aging is complex and their shared molecular drivers are deeply intertwined. This Review provides an overview of how different biological pathways affect cancer and aging...
Single-cell transcriptomic atlas of the human testis across the reproductive lifespan [0.03%]
人类睾丸的单细胞转录组图谱跨越生育生命周期
Lina Cui,Xichen Nie,Yixuan Guo et al.
Lina Cui et al.
Testicular aging is associated with declining reproductive health, but the molecular mechanisms are unclear. Here we generate a dataset of 214,369 single-cell transcriptomes from testicular cells of 35 individuals aged 21-69, offering a res...
Mahdi Moqri,Jesse R Poganik,Steve Horvath et al.
Mahdi Moqri et al.
A primary cilia-autophagy axis in hippocampal neurons is essential to maintain cognitive resilience [0.03%]
海马神经元中初级纤毛-自噬轴对维持认知弹性至关重要
Manon Rivagorda,David Romeo-Guitart,Victoria Blanchet et al.
Manon Rivagorda et al.
Blood-borne factors are essential to maintain neuronal synaptic plasticity and cognitive resilience throughout life. One such factor is osteocalcin (OCN), a hormone produced by osteoblasts that influences multiple physiological processes, i...
Author Correction: Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells [0.03%]
作者更正：源自生态位的4A半乳糖凝集素保护髓系偏向的造血干细胞的功能性身份
Dorsa Toghani,Sanika Gupte,Sharon Zeng et al.
Dorsa Toghani et al.
Published Erratum
Nature aging. 2025 Feb 20. DOI:10.1038/s43587-025-00837-x 2025
Large-scale proteomic analyses of incident Parkinson's disease reveal new pathophysiological insights and potential biomarkers [0.03%]
帕金森病的大型蛋白质组分析揭示了新的病理生理学见解和潜在生物标志物
Yi-Han Gan,Ling-Zhi Ma,Yi Zhang et al.
Yi-Han Gan et al.
The early pathophysiology of Parkinson's disease (PD) is poorly understood. We analyzed 2,920 Olink-measured plasma proteins in 51,804 UK Biobank participants, identifying 859 incident PD cases after 14.45 years. We found 38 PD-related prot...
Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan [0.03%]
旁分泌FGF21动态调节mTOR信号以调控一生中的胸腺功能
Sarah A Wedemeyer,Nicholas E Jones,Iwan G A Raza et al.
Sarah A Wedemeyer et al.
Consequences of age-associated thymic atrophy include declining T-cell responsiveness to pathogens and vaccines and diminished T-cell self-tolerance. Cortical thymic epithelial cells (cTECs) are primary targets of thymic aging, and recent s...