Frailty-associated dysbiosis of human microbiotas in older adults in nursing homes [0.03%]
护理机构老年人衰弱相关的肠道菌群失调特征
Julia Oh,Julie Robison,George A Kuchel
Julia Oh
Our longitudinal study comparing the skin, gut and oral microbiomes of community-dwelling older adults and nursing home residents showed striking changes known to be linked to antibiotic resistance and disease risk. Such shifts were associa...
Research and resource needs for understanding host immune responses to SARS-CoV-2 and COVID-19 vaccines during aging [0.03%]
用于了解宿主免疫反应对SARS-CoV-2和COVID-19疫苗随老化发生变化的研究和资源需求
Mercy PrabhuDas,Rebecca Fuldner,Donna Farber et al.
Mercy PrabhuDas et al.
On 16 and 17 March 2021, the National Institute of Allergy and Infectious Diseases and the National Institute of Aging convened a virtual workshop to discuss developments in SARS-CoV-2 research pertaining to immune responses in older adults...
Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan [0.03%]
optogenetics 使线虫寿命延长 mitochondria 膜电位恢复年轻态
Brandon J Berry,Anežka Vodičková,Annika Müller-Eigner et al.
Brandon J Berry et al.
Mitochondrial dysfunction plays a central role in aging but the exact biological causes are still being determined. Here, we show that optogenetically increasing mitochondrial membrane potential during adulthood using a light-activated prot...
Molecular Damage in Aging [0.03%]
分子损伤与衰老
Vadim N Gladyshev,Stephen B Kritchevsky,Steven G Clarke et al.
Vadim N Gladyshev et al.
Cellular metabolism generates molecular damage affecting all levels of biological organization. Accumulation of this damage over time is thought to play a central role in the aging process, but damage manifests in diverse molecular forms co...
Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs [0.03%]
年龄相关染色体结构蛋白Lamin变化通过干扰心脏转录谱导致心室功能障碍
Natalie J Kirkland,Scott H Skalak,Alexander J Whitehead et al.
Natalie J Kirkland et al.
As we age, structural changes contribute to progressive decline in organ function, which in the heart act through poorly characterized mechanisms. Taking advantage of the short lifespan and conserved cardiac proteome of the fruit fly, we fo...
Michael R Duggan,Keenan A Walker
Michael R Duggan
Genetic variation linked to lower levels of soluble ST2, a decoy cytokine receptor for IL-33, may protect against Alzheimer's disease in female APOEε4 carriers by increasing microglial plaque removal. This discovery advances our understand...
The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques [0.03%]
骨髓的年龄决定了动脉粥样硬化斑块中平滑肌源性细胞的克隆性
Inamul Kabir,Xinbo Zhang,Jui M Dave et al.
Inamul Kabir et al.
Aging is the predominant risk factor for atherosclerosis, the leading cause of death. Rare smooth muscle cell (SMC) progenitors clonally expand giving rise to up to ~70% of atherosclerotic plaque cells; however, the effect of age on SMC clo...
Limited Proteolysis-Mass Spectrometry Reveals Aging-Associated Changes in Cerebrospinal Fluid Protein Abundances and Structures [0.03%]
限制性蛋白酶谱-质谱法揭示脑脊液蛋白质丰度和结构的年龄相关变化
Steven R Shuken,Jarod Rutledge,Tal Iram et al.
Steven R Shuken et al.
Cerebrospinal fluid (CSF) proteins and their structures have been implicated repeatedly in aging and neurodegenerative diseases. Limited proteolysis-mass spectrometry (LiP-MS) is a method that enables proteome-wide screening for changes in ...
Alzheimer's disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment [0.03%]
与阿尔茨海默病相关的U1剪接核糖核蛋白剪接功能障碍导致神经元过度兴奋和认知障碍
Ping-Chung Chen,Xian Han,Timothy I Shaw et al.
Ping-Chung Chen et al.
Recent proteome and transcriptome profiling of Alzheimer's disease (AD) brains reveals RNA splicing dysfunction and U1 small nuclear ribonucleoprotein (snRNP) pathology containing U1-70K and its N-terminal 40-KDa fragment (N40K). Here we pr...
Inamul Kabir,Daniel M Greif
Inamul Kabir
Cellular senescence and smooth muscle cells are key features of the atherosclerotic plaque; however, how senescent cells regulate smooth muscle cells is largely unknown. Herein, a new study in Nature Aging illuminates this interplay, provid...