Chi Zhang,Rui Yi
Chi Zhang
A stress-induced miR-31-CLOCK-ERK pathway is a key driver and therapeutic target for skin aging [0.03%]
应激诱导的miR-31-CLOCK-ERK通路是皮肤衰老的关键驱动因子和治疗靶点
Yao Yu,Xia Zhang,Fengzhen Liu et al.
Yao Yu et al.
Regressive changes in epithelial stem cells underlie mammalian skin aging, but the driving mechanisms are not well understood. Here, we report that mouse skin hair follicle stem cell (HFSC) aging is initiated by their intrinsic upregulation...
Hypoxia compromises the mitochondrial metabolism of Alzheimer's disease microglia via HIF1 [0.03%]
缺氧通过HIF1损害阿尔茨海默病小胶质细胞的线粒体代谢
Rosana March-Diaz,Nieves Lara-Ureña,Carmen Romero-Molina et al.
Rosana March-Diaz et al.
Genetic Alzheimer's disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), but the contribution of modifiable AD risk factors to microglial dysfunction is unknown. In AD mouse models, we o...
Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline [0.03%]
衰老大脑中细胞毒性T细胞的积累导致轴突退化并促进认知和运动功能下降
Janos Groh,Konrad Knöpper,Panagiota Arampatzi et al.
Janos Groh et al.
Aging is a major risk factor for the development of nervous system functional decline, even in the absence of diseases or trauma. The axon-myelin units and synaptic terminals are some of the neural structures most vulnerable to aging-relate...
Exosomal transfer of osteoclast-derived miRNAs to chondrocytes contributes to osteoarthritis progression [0.03%]
骨关节炎进展中破骨细胞来源的miRNA通过外泌体转移至软骨细胞中的作用及机制研究
Jin Liu,Xiaohao Wu,Jun Lu et al.
Jin Liu et al.
Osteoarthritis (OA) is a prevalent aging-related joint disease lacking disease-modifying therapies. Here, we identified an upregulation of circulating exosomal osteoclast (OC)-derived microRNAs (OC-miRNAs) during the progression of surgery-...
Mary McMahon,Craig Forester,Rochelle Buffenstein
Mary McMahon
The mechanistic causes of aging, the time-related decline in function and good health that leads to increased mortality, remain poorly understood. Here we propose that age-dependent alteration of the epitranscriptome, encompassing more than...
Ingrid Meulenbelt,Yolande F M Ramos,S Rubina Baglio et al.
Ingrid Meulenbelt et al.
John W Rowe
John W Rowe
Mark Zipkin
Mark Zipkin