The burden of rare protein-truncating genetic variants on human lifespan [0.03%]
罕见的蛋白质截短遗传变异对人类寿命的影响
Jimmy Z Liu,Chia-Yen Chen,Ellen A Tsai et al.
Jimmy Z Liu et al.
Genetic predisposition has been shown to contribute substantially to the age at which we die. Genome-wide association studies (GWASs) have linked more than 20 loci to phenotypes related to human lifespan1. However, little is known about how...
Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis [0.03%]
Kindlin-2维持关节软骨的完整性以预防骨关节炎
Xiaohao Wu,Yumei Lai,Sheng Chen et al.
Xiaohao Wu et al.
Osteoarthritis (OA) is an aging-related degenerative joint disease with a poorly defined mechanism. Here we report that kindlin-2 is highly expressed in articular chondrocytes and downregulated in the degenerated cartilage of aged mice and ...
Myc determines the functional age state of oligodendrocyte progenitor cells [0.03%]
MYC决定少突胶质前体细胞的功能年龄状态
Björn Neumann,Michael Segel,Tanay Ghosh et al.
Björn Neumann et al.
Like many adult stem cell populations, the capacity of oligodendrocyte progenitor cells (OPCs) to proliferate and differentiate is substantially impaired with aging. Previous work has shown that tissue-wide transient expression of the pluri...
Remaining true to one's identity [0.03%]
坚守本我
Joseph A Caruso,Thea D Tlsty
Joseph A Caruso
The ability to remain true to cellular identity and function is lost during aging and carcinogenesis when DNA damage triggers inflammation that progressively erodes homeostatic cues. Shalabi et al. show that these losses are accelerated in ...
Carina Groh,Johannes M Herrmann
Carina Groh
Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells [0.03%]
柠檬酸盐载体降解引起的染色质重塑损害了衰老间充质干细胞的成骨作用
Andromachi Pouikli,Swati Parekh,Monika Maleszewska et al.
Andromachi Pouikli et al.
Aging is accompanied by a general decline in the function of many cellular pathways. However, whether these are causally or functionally interconnected remains elusive. Here, we study the effect of mitochondrial-nuclear communication on ste...
Rare genetic coding variants associated with human longevity and protection against age-related diseases [0.03%]
与人类长寿和抗衰老相关疾病的罕见遗传密码变异关联性研究
Jhih-Rong Lin,Patrick Sin-Chan,Valerio Napolioni et al.
Jhih-Rong Lin et al.
Extreme longevity in humans has a strong genetic component, but whether this involves genetic variation in the same longevity pathways as found in model organisms is unclear. Using whole-exome sequences of a large cohort of Ashkenazi Jewish...
Marie Anne O&#x;Donnell,Briony Jain
Marie Anne O&#x;Donnell