Anna Kriebs
Anna Kriebs
SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response [0.03%]
SARS-CoV-2感染触发旁分泌衰老并导致持续的衰老相关炎症反应
Shunya Tsuji,Shohei Minami,Rina Hashimoto et al.
Shunya Tsuji et al.
Reports of post-acute COVID-19 syndrome, in which the inflammatory response persists even after SARS-CoV-2 has disappeared, are increasing1, but the underlying mechanisms of post-acute COVID-19 syndrome remain unknown. Here, we show that SA...
Ricardo Aparicio,Edward T Schmid,David W Walker
Ricardo Aparicio
Neurodegenerative diseases, including Parkinson’s disease, are linked to the accumulation of defective mitochondria in the brain and to microbial dysbiosis in the gut. However, the interplay between these factors is incompletely understood...
Trajectories of depressive symptoms in older adults and associated health outcomes [0.03%]
老年人抑郁症状的发展轨迹及其健康结局
Bruno Agustini,Mojtaba Lotfaliany,Mohammadreza Mohebbi et al.
Bruno Agustini et al.
With the progressive aging of the world's population, prolongation of a healthy lifespan in old age has become a medical research priority. The presence of depressive symptoms in later life is associated with poor health prognosis and incre...
Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty [0.03%]
人外周血的多维单细胞分析揭示了衰老和衰弱免疫图谱的特征性表现
Oscar Junhong Luo,Wen Lei,Guodong Zhu et al.
Oscar Junhong Luo et al.
Frailty is an intermediate status of the human aging process, associated with decompensated homeostasis and death. The immune phenotype of frailty and its underlying cellular and molecular processes remain poorly understood. We profiled 114...
Roel P H De Maeyer,Arne N Akbar
Roel P H De Maeyer
Suppression of intestinal dysfunction in a Drosophila model of Parkinson's disease is neuroprotective [0.03%]
帕金森病果蝇模型中肠道功能障碍的抑制具有神经保护作用
Giorgio Fedele,Samantha H Y Loh,Ivana Celardo et al.
Giorgio Fedele et al.
The innate immune response mounts a defense against foreign invaders and declines with age. An inappropriate induction of this response can cause diseases. Previous studies showed that mitochondria can be repurposed to promote inflammatory ...
Hongkai Zhao,Qianzhao Ji,Zeming Wu et al.
Hongkai Zhao et al.
Apolipoprotein E (APOE) is a component of lipoprotein particles that function in the homeostasis of cholesterol and other lipids. Although APOE is genetically associated with human longevity and Alzheimer's disease, its mechanistic role in ...
Lu Wang,Zhixun Dou
Lu Wang