Risks, real and imagined [0.03%]
真风险与假想的风险
Adam Bulley,Daniel L Schacter
Adam Bulley
RNA sequencing of whole blood reveals early alterations in immune cells and gene expression in Parkinson's disease [0.03%]
对整个血液的RNA测序发现帕金森病早期免疫细胞和基因表达的变化
David W Craig,Elizabeth Hutchins,Ivo Violich et al.
David W Craig et al.
Changes in the blood-based RNA transcriptome have the potential to inform biomarkers of Parkinson's disease (PD) progression. Here we sequenced a discovery set of whole-blood RNA species in 4,871 longitudinally collected samples from 1,570 ...
Post-GWAS functional analysis identifies CUX1 as a regulator of p16INK4a and cellular senescence [0.03%]
GWAS后期功能分析鉴定出CUX1是p16INK4a和细胞衰老的调节因子
Danli Jiang,Wei Sun,Ting Wu et al.
Danli Jiang et al.
Accumulation of senescent cells with age is an important driver of aging and age-related diseases. However, the mechanisms and signaling pathways that regulate senescence remain elusive. In this report, we performed post-genome-wide associa...
Adelyne Sue Li Chan,Masashi Narita
Adelyne Sue Li Chan
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer's disease patients [0.03%]
基于阿尔茨海默病患者的大规模单个诱导多能干细胞系解析神经元Aβ生成的多基因结构
Takayuki Kondo,Norikazu Hara,Satoshi Koyama et al.
Takayuki Kondo et al.
Genome-wide association studies have demonstrated that polygenic risks shape Alzheimer's disease (AD). To elucidate the polygenic architecture of AD phenotypes at a cellular level, we established induced pluripotent stem cells from 102 pati...
Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank [0.03%]
英国生物样本库中474074名参与者的确证和初步端粒长度表型特征研究
V Codd,M Denniff,C Swinfield et al.
V Codd et al.
Leukocyte telomere length (LTL) is a proposed marker of biological age. Here we report the measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We confirm that older age and male sex associate with shorter ...
Sara Hägg,Yiqiang Zhan
Sara Hägg
Ronald C Petersen
Ronald C Petersen
Mitsukuni Yoshida,Rajendra S Apte
Mitsukuni Yoshida
Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction [0.03%]
NAD依赖的昼夜节律类固醇生成活性介导的眼睑板腺年龄相关功能障碍intracrine活动涉及
Lena Sasaki,Yuki Hamada,Daisuke Yarimizu et al.
Lena Sasaki et al.
Canonically, hormones are produced in the endocrine organs and delivered to target tissues. However, for steroids, the concept of tissue intracrinology, whereby hormones are produced in the tissues where they exert their effect without rele...