Chae Ho Lim,Mayumi Ito
Chae Ho Lim
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease [0.03%]
IL1RL1基因变异降低淀粉样脑血管病患者sST2水平和APOE-ε4风险效应在女性阿尔茨海默病患者中的作用
Yuanbing Jiang,Xiaopu Zhou,Hiu Yi Wong et al.
Yuanbing Jiang et al.
Changes in the levels of circulating proteins are associated with Alzheimer's disease (AD), whereas their pathogenic roles in AD are unclear. Here, we identified soluble ST2 (sST2), a decoy receptor of interleukin-33-ST2 signaling, as a new...
Matej Durik,William M Keyes
Matej Durik
Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin [0.03%]
血管萎缩导致微环境硬化并促进老化皮肤表皮干细胞分化增强
Ryo Ichijo,Koichiro Maki,Mio Kabata et al.
Ryo Ichijo et al.
Stem cell loss causes tissue deterioration associated with aging. The accumulation of genomic and oxidative stress-induced DNA damage is an intrinsic cue for stem cell loss1,2; however, whether there is an external microenvironmental cue th...
Author Correction: An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging [0.03%]
作者更正：基于深度学习的炎性衰老时钟（iAge）可跟踪多发病，免疫衰老，衰弱和心血管老化
Nazish Sayed,Yingxiang Huang,Khiem Nguyen et al.
Nazish Sayed et al.
Published Erratum
Nature aging. 2021 Aug;1(8):748. DOI:10.1038/s43587-021-00102-x 2021
Susan E Howlett,Andrew D Rutenberg,Kenneth Rockwood
Susan E Howlett
Frailty is a multiply determined, age-related state of increased risk for adverse health outcomes. We review how the degree of frailty conditions the development of late-life diseases and modifies their expression. The risks for frailty ran...
Rochellys Diaz Heijtz,Ayoze Gonzalez-Santana,Jon D Laman
Rochellys Diaz Heijtz
Microbiota from young mice counteracts selective age-associated behavioral deficits [0.03%]
年轻小鼠的微生物群可以改善与年龄相关的特定行为缺陷
Marcus Boehme,Katherine E Guzzetta,Thomaz F S Bastiaanssen et al.
Marcus Boehme et al.
The gut microbiota is increasingly recognized as an important regulator of host immunity and brain health. The aging process yields dramatic alterations in the microbiota, which is linked to poorer health and frailty in elderly populations....