Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures [0.03%]
百岁老人的长寿与其肠道微生物群中具有青年标志的特征有关
Shifu Pang,Xiaodong Chen,Zhilong Lu et al.
Shifu Pang et al.
Centenarians are an excellent model to study the relationship between the gut microbiome and longevity. To characterize the gut microbiome signatures of aging, we conducted a cross-sectional investigation of 1,575 individuals (20-117 years)...
Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes [0.03%]
在两个欧洲队列中开发和验证DNA甲基化评分可增强对2型糖尿病的10年风险预测能力
Yipeng Cheng,Danni A Gadd,Christian Gieger et al.
Yipeng Cheng et al.
Type 2 diabetes mellitus (T2D) presents a major health and economic burden that could be alleviated with improved early prediction and intervention. While standard risk factors have shown good predictive performance, we show that the use of...
Nikita Isima,Jesús Gil
Nikita Isima
Spurious intragenic transcription is a feature of mammalian cellular senescence and tissue aging [0.03%]
错误的基因内转录是哺乳动物细胞衰老和组织老化的一个特征
Payel Sen,Greg Donahue,Catherine Li et al.
Payel Sen et al.
Mammalian aging is characterized by the progressive loss of tissue function and increased risk for disease. Accumulation of senescent cells in aging tissues partly contributes to this decline, and targeted depletion of senescent cells in vi...
Olivia Y Zhou,Anne Brunet
Olivia Y Zhou
The ability of adult neural stem cells to produce new neurons (neurogenesis) declines markedly during aging, but exactly how this occurs is largely unknown. Using sophisticated in vivo imaging, a study in Nature Aging shows that aging affec...
Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults [0.03%]
老年人接受灭活冠状病毒-2疫苗后细胞免疫受损是由于抗原特异性T细胞克隆重建不足所致
Chanchan Xiao,Zhiyao Ren,Bei Zhang et al.
Chanchan Xiao et al.
Aging is a critical risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine efficacy. The immune responses to inactivated vaccine for older adults, and the underlying mechanisms of potential differences to young...
CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer's disease [0.03%]
阿尔茨海默病患者脑脊液tau蛋白T217和T205磷酸化占有率能更好地反映淀粉样蛋白和tau病理变化
Nicolas R Barthélemy,Benjamin Saef,Yan Li et al.
Nicolas R Barthélemy et al.
Cerebrospinal fluid (CSF) amyloid-β peptide (Aβ)42/Aβ40 and the concentration of tau phosphorylated at site 181 (p-tau181) are well-established biomarkers of Alzheimer's disease (AD). The present study used mass spectrometry to measure c...
Chronic in vivo imaging defines age-dependent alterations of neurogenesis in the mouse hippocampus [0.03%]
慢性活体成像定义了小鼠海马区神经发生的年龄依赖性变化
Yicheng Wu,Sara Bottes,Roberto Fisch et al.
Yicheng Wu et al.
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian hippocampus1. Advancing age leads to a decline in neurogenesis, which is associated with impaired cognition2,3. The cellular mechanisms causing reduced neurogene...
Alan A Cohen,Luigi Ferrucci,Tamàs Fülöp et al.
Alan A Cohen et al.
Having made substantial progress understanding molecules, cells, genes and pathways, aging biology research is now moving toward integration of these parts, attempting to understand how their joint dynamics may contribute to aging. Such a s...