Wolfgang Wagner
Wolfgang Wagner
Absence of care among community-dwelling older adults with dementia and functional limitations [0.03%]
痴呆和功能障碍的社区居住老年人中忽视照料的状况
Zhuoer Lin,Yuting Qian,Thomas M Gill et al.
Zhuoer Lin et al.
Assistance with daily activities is crucial for persons living with dementia and functional limitations, yet many face substantial challenges in accessing adequate care and support. Using harmonized longitudinal survey data (2012-2018) from...
Interleukin-12 signaling drives Alzheimer's disease pathology through disrupting neuronal and oligodendrocyte homeostasis [0.03%]
白细胞介素-12信号通过破坏神经元和少突胶质细胞的稳态推动阿尔茨海默病病理过程
Shirin Schneeberger,Seung Joon Kim,Maria N Geesdorf et al.
Shirin Schneeberger et al.
Neuroinflammation including interleukin (IL)-12/IL-23-signaling is central to Alzheimer's disease (AD) pathology. Inhibition of p40, a subunit of IL-12/IL-23, attenuates pathology in AD-like mice; however, its signaling mechanism and expres...
Ghita Ghislat,Inmaculada Tasset;Women in Autophagy
Ghita Ghislat
George Andrew S Inglis
George Andrew S Inglis
Anna Kriebs
Anna Kriebs
Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer's disease [0.03%]
亚细胞蛋白质组学和iPSC建模揭示了阿尔茨海默病轴突病理的可逆机制
Yifei Cai,Jean Kanyo,Rashaun Wilson et al.
Yifei Cai et al.
Dystrophic neurites (also termed axonal spheroids) are found around amyloid deposits in Alzheimer's disease (AD), where they impair axonal electrical conduction, disrupt neural circuits and correlate with AD severity. Despite their importan...
A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan [0.03%]
小鼠的类似麻木状态减缓了血液表观遗传衰老并延长健康寿命
Lorna Jayne,Aurora Lavin-Peter,Julian Roessler et al.
Lorna Jayne et al.
Torpor and hibernation are extreme physiological adaptations of homeotherms associated with pro-longevity effects. Yet the underlying mechanisms of how torpor affects aging, and whether hypothermic and hypometabolic states can be induced to...
Matteo Cerri
Matteo Cerri
Accelerating the promise of geroscience through The Academy of Health & Lifespan Research [0.03%]
通过《健康与寿命研究学院》推动长寿科学的承诺加速实现
Nir Barzilai,Risa Starr,Eric Verdin et al.
Nir Barzilai et al.