Mark S Lachs
Mark S Lachs
Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids [0.03%]
蛋氨酸通过调节干细胞功能和寿命来调控线虫摄食反应
Jiongming Lu,Ulrike Temp,Andrea Müller-Hartmann et al.
Jiongming Lu et al.
Dietary restriction (DR) promotes healthy aging in diverse species. Essential amino acids play a key role, but the molecular mechanisms are unknown. The evolutionarily conserved Sestrin protein, an inhibitor of activity of the target of rap...
Publisher Correction: Short-term air pollution, cognitive performance and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study [0.03%]
刊文更正：退伍军人管理局“老龄化规范研究”中的短期空气污染、认知性能和非甾体抗炎药使用状况之间的关系
Xu Gao,Brent Coull,Xihong Lin et al.
Xu Gao et al.
Published Erratum
Nature aging. 2021 Jun;1(6):566. DOI:10.1038/s43587-021-00075-x 2021
Douglas Galasko
Douglas Galasko
ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer's disease [0.03%]
AADvac1治疗阿尔茨海默病tau病理的II期随机对照试验ADAMANT
Petr Novak,Branislav Kovacech,Stanislav Katina et al.
Petr Novak et al.
Alzheimer's disease (AD) pathology is partly characterized by accumulation of aberrant forms of tau protein. Here we report the results of ADAMANT, a 24-month double-blinded, parallel-arm, randomized phase 2 multicenter placebo-controlled t...
Clinical Trial
Nature aging. 2021 Jun;1(6):521-534. DOI:10.1038/s43587-021-00070-2 2021
Andrew J Scott
Andrew J Scott
Improvements in life expectancy among high-income countries are increasingly occurring in later years. Efforts to exploit the malleability of age and the additional time longevity brings are already underway, but important roadblocks remain...
Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer's disease [0.03%]
定量磷酸蛋白质组学揭示了阿尔茨海默病中失调的激酶网络
Nader Morshed,Meelim J Lee,Felicia H Rodriguez et al.
Nader Morshed et al.
Alzheimer's disease (AD) is a form of dementia characterized by amyloid-β plaques and tau neurofibrillary tangles that progressively disrupt neural circuits in the brain. The signaling networks underlying AD pathological changes are poorly...
Gunnar Brinkmalm,Henrik Zetterberg
Gunnar Brinkmalm
Cellular and plasma proteomic determinants of COVID-19 and non-COVID-19 pulmonary diseases relative to healthy aging [0.03%]
相对于健康衰老，COVID-19和非COVID-19肺部疾病的相关细胞和血浆蛋白质组决定因素
Laura Arthur,Ekaterina Esaulova,Denis A Mogilenko et al.
Laura Arthur et al.
We examine the cellular and soluble determinants of coronavirus disease 2019 (COVID-19) relative to aging by performing mass cytometry in parallel with clinical blood testing and plasma proteomic profiling of ~4,700 proteins from 71 individ...