Bruno Conti,Rafael de Cabo
Bruno Conti
Core body temperature (Tb) is a long-established determinant of longevity across species. In this Perspective, we first summarize evidence demonstrating that reducing Tb increases lifespan and that lowered Tb contributes to the antiaging ef...
Regeneration leads to global tissue rejuvenation in aging sexual planarians [0.03%]
平性涡虫的再生可使其年老组织恢复活力
Xiaoting Dai,Xinghua Li,Alexander Tyshkovskiy et al.
Xiaoting Dai et al.
The possibility of reversing the adverse impacts of aging could significantly reduce age-related diseases and improve quality of life in older populations. Here we report that the sexual lineage of the planarian Schmidtea mediterranea exhib...
The advantages and challenges of disability-free survival as outcome measure in clinical studies [0.03%]
无残疾生存作为临床研究终点测量的优劣挑战
Johannes T Neumann,John J McNeil
Johannes T Neumann
Transcriptional profiles of mouse oligodendrocyte precursor cells across the lifespan [0.03%]
小鼠少突胶质细胞前体细胞的转录谱在整个生命周期中的变化
Dongeun Heo,Anya A Kim,Björn Neumann et al.
Dongeun Heo et al.
Oligodendrocyte progenitor cells (OPCs) are highly dynamic, widely distributed glial cells of the central nervous system responsible for generating myelinating oligodendrocytes throughout life. However, the rates of OPC proliferation and di...
Erik Jacques,Chiara Herzog,Kejun Ying et al.
Erik Jacques et al.
Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials [0.03%]
血浆p-tau217和tau-PET预测认知正常个体未来认知衰退：对临床试验的影响
Rik Ossenkoppele,Gemma Salvadó,Shorena Janelidze et al.
Rik Ossenkoppele et al.
Plasma p-tau217 and tau positron emission tomography (PET) are strong prognostic biomarkers in Alzheimer's disease (AD), but their relative performance in predicting future cognitive decline among cognitively unimpaired (CU) individuals is ...
Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape [0.03%]
在个体年龄相关CpG位点进行表观遗传编辑会影响全基因组的表观遗传老化景观
Sven Liesenfelder,Mohamed H Elsafi Mabrouk,Jessica Iliescu et al.
Sven Liesenfelder et al.
Aging is reflected by genome-wide DNA methylation changes, which form the basis of epigenetic clocks, but it is largely unclear how these epigenetic modifications are regulated and whether they directly affect the aging process. In this stu...
A systematic review with a Burden of Proof meta-analysis of health effects of long-term ambient fine particulate matter (PM2.5) exposure on dementia [0.03%]
长期环境细颗粒物(PM2.5)暴露对痴呆症健康影响的系统评价和负担证明meta分析
Xinmei Huang,Jaimie Steinmetz,Elizabeth K Marsh et al.
Xinmei Huang et al.
Previous studies have indicated increased dementia risk associated with fine particulate matter (PM2.5) exposure; however, the findings are inconsistent. In this systematic review, we assessed the association between long-term PM2.5 exposur...