Anton Wutz
Anton Wutz
KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging [0.03%]
KLRG1识别出的调节性T细胞随着衰老线粒体发生改变
Gonzalo Soto-Heredero,Enrique Gabandé-Rodríguez,Elisa Carrasco et al.
Gonzalo Soto-Heredero et al.
Recent studies using single-cell RNA sequencing technology have uncovered several subpopulations of CD4+ T cells that accumulate with aging. These age-associated T cells are emerging as relevant players in the onset of inflammaging and tiss...
Valuing caregiving is a prerequisite for the wellbeing economy and mental wealth [0.03%]
重视照料工作是良好经济和心理健康的前提条件
Mouna Sawan,Saman Khalatbari-Soltani,Anita van Zwieten et al.
Mouna Sawan et al.
Hannah Walters
Hannah Walters
The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity [0.03%]
由逆转座子衍生的衣壳基因PNMA1和PNMA4维持生殖能力
Thomas W P Wood,William S Henriques,Harrison B Cullen et al.
Thomas W P Wood et al.
Almost half of the human genome consists of retrotransposons-'parasitic' sequences that insert themselves into the host genome via an RNA intermediate. Although most of these sequences are silenced or mutationally deactivated, they can pres...
Pre-symptomatic Parkinson's disease blood test quantifying repetitive sequence motifs in transfer RNA fragments [0.03%]
帕金森病血液检测量化转移RNA片段中重复序列动机
Nimrod Madrer,Shani Vaknine-Treidel,Tamara Zorbaz et al.
Nimrod Madrer et al.
Early, efficient Parkinson's disease (PD) tests may facilitate pre-symptomatic diagnosis and disease-modifying therapies. Here we report elevated levels of PD-specific transfer RNA fragments carrying a conserved sequence motif (RGTTCRA-tRFs...
Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer [0.03%]
单细胞和空间转录组揭示早发和晚发前列腺癌不同的微环境及进展标志物
Yifei Cheng,Bingxin Liu,Junyi Xin et al.
Yifei Cheng et al.
The clinical and pathological outcomes differ between early-onset (diagnosed in men ≤55 years of age) and late-onset prostate cancer, potentially attributed to the changes in hormone levels and immune activities associated with aging. Expl...
New biomarkers for early-stage tau pathology in Alzheimer's disease [0.03%]
阿尔茨海默病早期tau蛋白病理生物标志物的新进展
Rongcan Luo,Jin-Tai Yu
Rongcan Luo