Caroline A Doherty,Diana J Laird
Caroline A Doherty
Reference centiles for intrinsic capacity to monitor clinical health outcomes in real-world primary care cohorts [0.03%]
参考标准百分位数：监测现实世界全科医疗队列的临床健康结果的内在能力
Philipe de Souto Barreto,Wan-Hsuan Lu,Neda Tavassoli et al.
Philipe de Souto Barreto et al.
Intrinsic capacity (IC) refers to physical and mental capacities that determine healthy aging. IC is the central element of the World Health Organization care pathway 'Integrated Care for Older People' (ICOPE). However, the operationalizati...
Author Correction: Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer [0.03%]
作者更正：单细胞和空间转录组揭示早发与晚发前列腺癌的不同微环境及进展标志物
Yifei Cheng,Bingxin Liu,Junyi Xin et al.
Yifei Cheng et al.
Published Erratum
Nature aging. 2025 May 12. DOI:10.1038/s43587-025-00892-4 2025
Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging [0.03%]
肠道微生物群依赖性苯乙酸的增加在衰老过程中诱导内皮细胞衰老
Seyed Soheil Saeedi Saravi,Benoit Pugin,Florentin Constancias et al.
Seyed Soheil Saeedi Saravi et al.
Endothelial cell senescence is a key driver of cardiovascular aging, yet little is known about the mechanisms by which it is induced in vivo. Here we show that the gut bacterial metabolite phenylacetic acid (PAA) and its byproduct, phenylac...
Yahyah Aman
Yahyah Aman
Sierra Lore,Jesse R Poganik,Anthony Atala et al.
Sierra Lore et al.
Substantial progress in aging research continues to deepen our understanding of the fundamental mechanisms of aging, yet there is a lack of interventions conclusively shown to attenuate the processes of aging in humans. By contrast, replace...
Frank A Middleton
Frank A Middleton
Quasi-spatial single-cell transcriptome based on physical tissue properties defines early aging associated niche in liver [0.03%]
基于物理组织属性的类空间单细胞转录组定义了肝脏早期衰老相关的微环境
Kwon Yong Tak,Juyeon Kim,Myungsun Park et al.
Kwon Yong Tak et al.
Aging is associated with the accumulation of senescent cells, which are triggered by tissue injury response and often escape clearance by the immune system. The specific traits and diversity of these cells in aged tissues, along with their ...
Anita van Zwieten,Suraj Samtani,Mouna Sawan et al.
Anita van Zwieten et al.
Aging promotes reactivation of the Barr body at distal chromosome regions [0.03%]
衰老促进巴尔体远端染色体区域的再激活
Sarah Hoelzl,Tim P Hasenbein,Stefan Engelhardt et al.
Sarah Hoelzl et al.
Decades ago, evidence of age-related reactivation of a single gene on the female inactive X chromosome was observed in mice. While stable silencing of the Barr body is crucial for balancing gene dosage between sexes, it remains unclear whet...