Emerging role of mitochondrial calcium levels in cellular senescence and in switching cell fates [0.03%]
线粒体钙信号在细胞衰老及调控细胞命运转变中的作用
Céline Margand,Pablo Morgado-Cáceres,Ulises Ahumada-Castro et al.
Céline Margand et al.
Pace of Aging analysis of healthspan and lifespan in older adults in the US and UK [0.03%]
美国和英国老年人的健康寿命和寿命的衰老速度分析
Arun Balachandran,Heming Pei,Yifan Shi et al.
Arun Balachandran et al.
As societies age, policy makers need tools to understand how demographic aging will affect population health and to develop programs to increase healthspan. The current metrics used for policy do not distinguish differences caused by early-...
Aberrant engagement of P-selectin drives hematopoietic stem cell aging in mice [0.03%]
小鼠造血干细胞衰老由P-选择素异常激活引起
Daozheng Yang,Natalia Skinder,Yun-Ruei Kao et al.
Daozheng Yang et al.
During aging, hematopoietic stem cell (HSC) function progressively declines which can lead to reduced blood cell production and regeneration. This work uncovered that cell surface presentation of P-selectin (CD62P, encoded by Selp) increase...
GLP-1R agonists protect against Alzheimer's disease by rewiring energy regulation [0.03%]
GLP-1受体激动剂通过重新布线能量调节来对抗阿尔茨海默病
Daxiang Na,Marc Schneeberger Pané
Daxiang Na
Activation of AMPK by GLP-1R agonists mitigates Alzheimer-related phenotypes in transgenic mice [0.03%]
GLP-1受体激动剂通过活化AMPK缓解转基因小鼠的阿尔茨海默病表型
Yun Zhang,Huaqiu Chen,Yijia Feng et al.
Yun Zhang et al.
Individuals with type 2 diabetes mellitus have an increased risk of developing Alzheimer's disease (AD). GLP-1 receptor agonists (GLP-1RAs) are used for glycemic control in diabetes and show potential neuroprotective properties, but their e...
Large-scale plasma proteomic profiling unveils diagnostic biomarkers and pathways for Alzheimer's disease [0.03%]
大规模血浆蛋白质组学研究揭示了阿尔茨海默病的诊断生物标志物和发病机制
Gyujin Heo,Ying Xu,Erming Wang et al.
Gyujin Heo et al.
Proteomic studies have been instrumental in identifying brain, cerebrospinal fluid and plasma proteins associated with Alzheimer's disease (AD). Here, we comprehensively examined 6,905 aptamers corresponding to 6,106 unique proteins in plas...
Yue Wang,Ping Zhou,Hongying Shan et al.
Yue Wang et al.
Whether and how endometrial aging affects fertility remains unclear. In our in-house clinical cohort at the Center for Reproductive Medicine of Peking University Third Hospital (n = 1,149), we observed adverse pregnancy outcomes in the midd...
mRNA metabolism regulator human antigen R (HuR) regulates age-related hearing loss in aged mice [0.03%]
人抗原R（HuR）调控小鼠老化相关的听力损失
Siwei Guo,Jieying Cao,Guodong Hong et al.
Siwei Guo et al.
Age-related hearing loss (ARHL) is among the most prevalent and complex disorders in older adults. However, the pathogenesis of ARHL remains poorly understood. Using a single-cell transcriptomic landscape of mouse cochlea at five time point...
Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis [0.03%]
靶向染色质重塑因子BAZ2B可减轻肝衰老和MASH纤维化
Chuantao Tu,Cheng Qian,Shuyu Li et al.
Chuantao Tu et al.
With increased age, the liver becomes more vulnerable to metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis. Deciphering the complex interplay between aging, the emergence of senescent cells in the liver and MASH fibrosis...
Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration [0.03%]
基于脑脊液蛋白质组的大规模网络分析鉴定出额颞叶变性的分子标志物
Rowan Saloner,Adam M Staffaroni,Eric B Dammer et al.
Rowan Saloner et al.
The pathophysiological mechanisms driving disease progression of frontotemporal lobar degeneration (FTLD) and corresponding biomarkers are not fully understood. Here we leveraged aptamer-based proteomics (>4,000 proteins) to identify dysreg...