Xiaotao Shen,Chuchu Wang,Xin Zhou et al.
Xiaotao Shen et al.
Aging is a complex process associated with nearly all diseases. Understanding the molecular changes underlying aging and identifying therapeutic targets for aging-related diseases are crucial for increasing healthspan. Although many studies...
Exploring how APOE ε4 increases Alzheimer's disease risk in women [0.03%]
探究APOE ε4基因如何增加女性患阿尔茨海默病的风险
George Andrew S Inglis
George Andrew S Inglis
Real-life intrinsic capacity screening data from the ICOPE-Care program [0.03%]
ICOPE-Care计划的实际内在能力筛查数据
Philipe de Souto Barreto,Emmanuel Gonzalez-Bautista,Heike A Bischoff-Ferrari et al.
Philipe de Souto Barreto et al.
The Integrated Care for Older People (ICOPE) program is a healthcare pathway that uses a screening test for intrinsic capacity (IC) as its entry point. However, real-life data informing on how IC domains cluster and change over time, as wel...
Liang-Kung Chen
Liang-Kung Chen
Hannah Walters
Hannah Walters
José P Castro,Anastasia V Shindyapina,Alessandro Barbieri et al.
José P Castro et al.
Although cancer is an age-related disease, how the processes of aging contribute to cancer progression is not well understood. In this study, we uncovered how mouse B cell lymphoma develops as a consequence of a naturally aged system. We sh...
Maternal age enhances purifying selection on pathogenic mutations in complex I genes of mammalian mtDNA [0.03%]
高龄产妇会增强对哺乳动物线粒体DNA复杂I基因的致病突变的选择压力
Yanfei Ru,Xiaoling Deng,Jiatong Chen et al.
Yanfei Ru et al.
Mitochondrial diseases, caused mainly by pathogenic mitochondrial DNA (mtDNA) mutations, pose major challenges due to the lack of effective treatments. Investigating the patterns of maternal transmission of mitochondrial diseases could pave...
Separation of reproductive decline from lifespan extension during methionine restriction [0.03%]
蛋氨酸限制条件下甲硫氨酸限制条件下的生殖衰退与寿命延长的分离
Fangchao Wei,Shiyu Liu,Juan Liu et al.
Fangchao Wei et al.
Lifespan-extending interventions are generally thought to result in reduced fecundity. The generality of this principle and how it may extend to nutrition and metabolism is not understood. We considered dietary methionine restriction (MR), ...
Helena M Cochemé,Jesús Gil
Helena M Cochemé