Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome [0.03%]
核糖体S6蛋白激酶1通过衰老分泌组调节炎症老化
Suchira Gallage,Elaine E Irvine,Jose Efren Barragan Avila et al.
Suchira Gallage et al.
Inhibition of S6 kinase 1 (S6K1) extends lifespan and improves healthspan in mice, but the underlying mechanisms are unclear. Cellular senescence is a stable growth arrest accompanied by an inflammatory senescence-associated secretory pheno...
Martin Alvarez-Kuglen,Kenta Ninomiya,Haodong Qin et al.
Martin Alvarez-Kuglen et al.
For efficient, cost-effective and personalized healthcare, biomarkers that capture aspects of functional, biological aging, thus predicting disease risk and lifespan more accurately and reliably than chronological age, are essential. We dev...
Author Correction: Rare genetic coding variants associated with human longevity and protection against age-related diseases [0.03%]
作者更正：与人类长寿和抵抗年龄相关疾病保护作用相关的罕见遗传编码变异
Jhih-Rong Lin,Patrick Sin-Chan,Valerio Napolioni et al.
Jhih-Rong Lin et al.
Published Erratum
Nature aging. 2024 Sep;4(9):1328. DOI:10.1038/s43587-024-00708-x 2024
The promise of machine learning approaches to capture cellular senescence heterogeneity [0.03%]
机器学习方法捕捉细胞衰老异质性的前景
Imanol Duran,Cleo L Bishop,Jesús Gil et al.
Imanol Duran et al.
Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer's disease [0.03%]
血清蛋白质组学揭示了载脂蛋白E-ε4依赖性和载脂蛋白E-ε4非依赖性的阿尔茨海默病蛋白质特征
Elisabet A Frick,Valur Emilsson,Thorarinn Jonmundsson et al.
Elisabet A Frick et al.
A deeper understanding of the molecular processes underlying late-onset Alzheimer's disease (LOAD) could aid in biomarker and drug target discovery. Using high-throughput serum proteomics in the prospective population-based Age, Gene/Enviro...
Accelerometer-derived 'weekend warrior' physical activity pattern and brain health [0.03%]
基于加速度计的“周末 warriors”身体活动模式与大脑健康之间的关系
Jiahao Min,Zhi Cao,Tingshan Duan et al.
Jiahao Min et al.
Extensive evidence shows the beneficial effect of adhering to a regular physical activity (PA) pattern on brain health. However, whether the 'weekend warrior' pattern, characterized by concentrated moderate-to-vigorous PA (MVPA) over 1-2 da...
Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage [0.03%]
淋巴回流在脑脊液引流及抗衰老中的作用研究
Ting Du,Aditya Raghunandan,Humberto Mestre et al.
Ting Du et al.
Cervical lymphatic vessels (cLVs) have been shown to drain solutes and cerebrospinal fluid (CSF) from the brain. However, their hydrodynamical properties have never been evaluated in vivo. Here, we developed two-photon optical imaging with ...
Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline [0.03%]
蛋白质组学识别出了潜在的免疫学驱动因素，这些因素导致感染后的脑萎缩和认知能力下降
Michael R Duggan,Zhongsheng Peng,Pyry N Sipilä et al.
Michael R Duggan et al.
Infections have been associated with the incidence of Alzheimer disease and related dementias, but the mechanisms responsible for these associations remain unclear. Using a multicohort approach, we found that influenza, viral, respiratory, ...